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Full-Text Articles in Cell and Developmental Biology
An Evolving Epigenome That Determines Tissue And Cell Specificity, Renee Louise Sears
An Evolving Epigenome That Determines Tissue And Cell Specificity, Renee Louise Sears
Arts & Sciences Electronic Theses and Dissertations
Understanding the mechanisms driving phenotypic variation is a major goal of biology that unifies classical genetics with the emerging fields of genomics and epigenomics. Human and mouse share over 90% of genes and global tissue-specific patterns of expression are maintained between the species. Thus, it is hypothesized that gene expression is influenced through distinctive regulation among species in order to account for the unmistakable phenotypic divergence. DNA methylation, histone modifications, open chromatin patterns, transcription factor binding, and other epigenetic factors are all associated with shaping, maintaining, and repressing regulatory regions which in turn coordinate gene expression. It is vital to …
Human-Specific Histone Methylation Signatures At Transcription Start Sites In Prefrontal Neurons, Hennady Shulha, Jessica Crisci, Denis Reshetov, Jogender Tushir, Iris Cheung, Rahul Bharadwaj, Hsin-Jung Chou, Isaac Houston, Cyril Peter, Amanda Mitchell, Wei-Dong Yao, Richard Myers, Jiang-Fan Chen, Todd Preuss, Evgeny Rogaev, Jeffrey Jensen, Zhiping Weng, Schahram Akbarian
Human-Specific Histone Methylation Signatures At Transcription Start Sites In Prefrontal Neurons, Hennady Shulha, Jessica Crisci, Denis Reshetov, Jogender Tushir, Iris Cheung, Rahul Bharadwaj, Hsin-Jung Chou, Isaac Houston, Cyril Peter, Amanda Mitchell, Wei-Dong Yao, Richard Myers, Jiang-Fan Chen, Todd Preuss, Evgeny Rogaev, Jeffrey Jensen, Zhiping Weng, Schahram Akbarian
Hsin-Jung Chou
Cognitive abilities and disorders unique to humans are thought to result from adaptively driven changes in brain transcriptomes, but little is known about the role of cis-regulatory changes affecting transcription start sites (TSS). Here, we mapped in human, chimpanzee, and macaque prefrontal cortex the genome-wide distribution of histone H3 trimethylated at lysine 4 (H3K4me3), an epigenetic mark sharply regulated at TSS, and identified 471 sequences with human-specific enrichment or depletion. Among these were 33 loci selectively methylated in neuronal but not non-neuronal chromatin from children and adults, including TSS at DPP10 (2q14.1), CNTN4 and CHL1 (3p26.3), and other neuropsychiatric susceptibility …
Human-Specific Histone Methylation Signatures At Transcription Start Sites In Prefrontal Neurons, Hennady P. Shulha, Jessica L. Crisci, Denis Reshetov, Jogender S. Tushir, Iris Cheung, Rahul Bharadwaj, Hsin-Jung Chou, Isaac B. Houston, Cyril J. Peter, Amanda C. Mitchell, Wei-Dong Yao, Richard H. Myers, Jiang-Fan Chen, Todd M. Preuss, Evgeny I. Rogaev, Jeffrey D. Jensen, Zhiping Weng, Schahram Akbarian
Human-Specific Histone Methylation Signatures At Transcription Start Sites In Prefrontal Neurons, Hennady P. Shulha, Jessica L. Crisci, Denis Reshetov, Jogender S. Tushir, Iris Cheung, Rahul Bharadwaj, Hsin-Jung Chou, Isaac B. Houston, Cyril J. Peter, Amanda C. Mitchell, Wei-Dong Yao, Richard H. Myers, Jiang-Fan Chen, Todd M. Preuss, Evgeny I. Rogaev, Jeffrey D. Jensen, Zhiping Weng, Schahram Akbarian
Jessica L Crisci
Cognitive abilities and disorders unique to humans are thought to result from adaptively driven changes in brain transcriptomes, but little is known about the role of cis-regulatory changes affecting transcription start sites (TSS). Here, we mapped in human, chimpanzee, and macaque prefrontal cortex the genome-wide distribution of histone H3 trimethylated at lysine 4 (H3K4me3), an epigenetic mark sharply regulated at TSS, and identified 471 sequences with human-specific enrichment or depletion. Among these were 33 loci selectively methylated in neuronal but not non-neuronal chromatin from children and adults, including TSS at DPP10 (2q14.1), CNTN4 and CHL1 (3p26.3), and other neuropsychiatric susceptibility …