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Full-Text Articles in Cell and Developmental Biology
Whole-Genome Sequencing Of Kshv From Zambian Kaposi’S Sarcoma Biopsies Reveals Unique Viral Diversity, Landon N. Olp, Adrien Jeanniard, Clemence Marimo, John T. West, Charles Wood
Whole-Genome Sequencing Of Kshv From Zambian Kaposi’S Sarcoma Biopsies Reveals Unique Viral Diversity, Landon N. Olp, Adrien Jeanniard, Clemence Marimo, John T. West, Charles Wood
Nebraska Center for Virology: Faculty Publications
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent for Kaposi’s sarcoma (KS). Both KSHV and KS are endemic in sub-Saharan Africa where approximately 84% of global KS cases occur. Nevertheless, whole-genome sequencing of KSHV has only been completed using isolates from Western countries—where KS is not endemic. The lack of whole-genome KSHV sequence data from the most clinically important geographical region, sub-Saharan Africa, represents an important gap as it remains unclear whether genomic diversity has a role on KSHV pathogenesis. We hypothesized that distinct KSHV genotypes might be present in sub-Saharan Africa compared to Western countries. Using a KSHV-targeted enrichment …
Response Of Mammalian Macrophages To Challenge With The Chlorovirus Atcv-1, Thomas M. Petro, Irina V. Agarkova, You Zhou, Robert H. Yolken, James L. Van Etten, David D. Dunigan
Response Of Mammalian Macrophages To Challenge With The Chlorovirus Atcv-1, Thomas M. Petro, Irina V. Agarkova, You Zhou, Robert H. Yolken, James L. Van Etten, David D. Dunigan
Nebraska Center for Virology: Faculty Publications
It was recently reported that 44% of healthy humans in a study cohort had DNA sequences similar to Chlorovirus ATCV-1 (family Phycodnaviridae) in oropharyngeal samples and had decreases in visual processing and visual motor speed compared with individuals in whom no virus was detected. Moreover, mice inoculated orally with ATCV-1 developed immune responses to ATCV-1 proteins and had decreases in certain cognitive domains. Because heightened IL-6, nitric oxide (NO), and ERK MAP kinase activation from macrophages are linked to cognitive impairments, we evaluated cellular responses and viral plaque forming units in murine RAW264.7 and primary macrophages after exposure to …