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Full-Text Articles in Cell and Developmental Biology
Anti-Tumor Signaling Of Thyroid Hormone Receptor Beta In Breast And Thyroid Cancer Cells, Eric Bolf
Anti-Tumor Signaling Of Thyroid Hormone Receptor Beta In Breast And Thyroid Cancer Cells, Eric Bolf
Graduate College Dissertations and Theses
Dysregulation of the tumor suppressor thyroid hormone receptor beta (TRβ) is a frequent event in a number of solid tumors. As a nuclear hormone receptor, the primary function of TRβ is to regulate transcriptional activity in a ligand-dependent manner. However, TRβ activity is not well-defined and the pathways it regulates are not yet fully delineated. The two cancer types where TRβ is best studied are thyroid cancer and breast cancer. Interestingly, thyroid cancer is a risk factor for breast cancer and breast cancer is a risk factor for thyroid cancer, suggestive of an etiological link. Determining the molecular mechanisms of …
Glutathionylation/Glutaredoxin Axis And The Regulation Of Epithelial Cell Plasticity And Fibroblast Activation In Airway Fibrosis, Shi Biao Chia
Glutathionylation/Glutaredoxin Axis And The Regulation Of Epithelial Cell Plasticity And Fibroblast Activation In Airway Fibrosis, Shi Biao Chia
Graduate College Dissertations and Theses
Asthma is a complex lung disorder that affects more than 200 million people across the globe. About 10% of asthmatics have severe disease accompanied by structural airway remodeling, including subepithelial fibrosis, airway smooth muscle cell hyperplasia, goblet metaplasia, and increased vascularization. Oxidative stress has been well-linked to asthma pathogenesis; however, the precise redox mechanisms governing the pathological states are slowly being teased apart in the recent years. Protein S-glutathionylation (PSSG) is a posttranslational modification where a three amino acid-peptide, glutathione, forms a disulfide bond with reactive cysteines of a protein thereby potentially changing the protein’s biological functions. Glutaredoxins are members …