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Pannexin 1 Inhibition Delays Maturation And Improves Development Of Bos Taurus Oocytes, Zachary Timothy Dye, Lauren Virginia Rutledge, Silvia Penuela, Paul William Dyce

Anatomy and Cell Biology Publications

© 2020 The Author(s). Background: Intercellular exchange between the oocyte and its surrounding cells within the follicular environment is critical for oocyte maturation and subsequent development. In vertebrates this exchange is facilitated through gap junctions formed by connexin membrane proteins. Another family of membrane proteins called pannexins are able to form single membrane channels that allow cellular exchanges with the extracellular environment. The most ubiquitously expressed and studied member, pannexin 1 (PANX1), has yet to be described thoroughly in female reproductive tissues or functionally studied during oocyte maturation. Here, we look into the expression of pannexin 1 in bovine cumulus-oocyte …