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Full-Text Articles in Cell and Developmental Biology
Oncolytic Virotherapy Of Ovarian Cancer, Shoudong Li, Jessica Tong, Masmudur M. Rahman, Trevor G. Shepherd, Grant Mcfadden
Oncolytic Virotherapy Of Ovarian Cancer, Shoudong Li, Jessica Tong, Masmudur M. Rahman, Trevor G. Shepherd, Grant Mcfadden
Anatomy and Cell Biology Publications
In the past two decades, more than 20 viruses with selective tropism for tumor cells have been developed as oncolytic viruses (OVs) for treatments of a variety of malignancies. Of these viruses, eleven have been tested in human ovarian cancer models in preclinical studies. So far, nine phase I or II clinical trials have been conducted or initiated using four different types of OVs in patients with recurrent ovarian cancers. In this article, we summarize the different OVs that are being assessed as therapeutics for ovarian cancer. We also present an overview of recent advances in identification of key genetic …