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Articles 1 - 21 of 21
Full-Text Articles in Biotechnology
Egregious Error Or Admirable Advance: The Memorandum Of Understanding That Enables Federally Funded Basic Human Embryonic Stem Cell Research, Amy Ligler
Duke Law & Technology Review
Nothing contained herein shall be considered to be the grant of a commercial license or right under the Wisconsin Patent Rights or to Wisconsin Materials. Furthermore, nothing contained herein shall be construed to be a waiver of WiCell's patent rights under the Wisconsin Patent Rights or WiCell's property rights in Wisconsin Materials.
Patenting Resources: Biotechnology And The Concept Of Sustainable Development, Yvonne Cripps
Patenting Resources: Biotechnology And The Concept Of Sustainable Development, Yvonne Cripps
Indiana Journal of Global Legal Studies
No abstract provided.
A Reconsideration Of The Physicians’ Immunity Statute, Steve Dirksen
A Reconsideration Of The Physicians’ Immunity Statute, Steve Dirksen
Duke Law & Technology Review
The author assesses the "physicians' immunity statute" from legal policy, ethical, and financial perspectives, and concludes that alternatives such as licensure and monetary incentives would better serve the goal of encouraging invention more effectively by rewarding it.
Preparing For Bioinformatics Litigation: How Will The Courts Confront The Next Generation Of Biotechnology Patents?, Scott D. Locke, David A. Kalow
Preparing For Bioinformatics Litigation: How Will The Courts Confront The Next Generation Of Biotechnology Patents?, Scott D. Locke, David A. Kalow
Buffalo Intellectual Property Law Journal
No abstract provided.
The Clone Wars: The Growing Debate Over Federal Cloning Legislation, John Garvish
The Clone Wars: The Growing Debate Over Federal Cloning Legislation, John Garvish
Duke Law & Technology Review
As readers of science fiction are well aware, the term "clone" refers to asexually produced offspring, that is, offspring produced by a process of cell-division which does not begin with the union of two sex cells. A clone is the genetic twin of the cell donor. Propagation of plants by this method is, of course, commonplace, but mammalian reproduction in this fashion would indeed be a revolutionary accomplishment, with profound and disturbing implications.
Salivary Acinar Cells From Aquaporin 5-Deficient Mice Have Decreased Membrane Water Permeability And Altered Cell Volume Regulation, Carissa M. Krane, James E. Melvin, Ha-Van Nguyen, Linda Richardson, Jennifer E. Towne, Thomas Doetschman, Anil G. Menon
Salivary Acinar Cells From Aquaporin 5-Deficient Mice Have Decreased Membrane Water Permeability And Altered Cell Volume Regulation, Carissa M. Krane, James E. Melvin, Ha-Van Nguyen, Linda Richardson, Jennifer E. Towne, Thomas Doetschman, Anil G. Menon
Biology Faculty Publications
Aquaporins (AQPs) are channel proteins that regulate the movement of water through the plasma membrane of secretory and absorptive cells in response to osmotic gradients. In the salivary gland, AQP5 is the major aquaporin expressed on the apical membrane of acinar cells. Previous studies have shown that the volume of saliva secreted by AQP5-deficient mice is decreased, indicating a role for AQP5 in saliva secretion; however, the mechanism by which AQP5 regulates water transport in salivary acinar cells remains to be determined. Here we show that the decreased salivary flow rate and increased tonicity of the saliva secreted byAqp5 …
Studies On The Formation Of Dna-Cationic Lipid Composite Films And Dna Hybridization In The Composites, Murali Sastry, Vidya Ramakrishnan, Mrunalini Pattarkine, Krishna N. Ganesh
Studies On The Formation Of Dna-Cationic Lipid Composite Films And Dna Hybridization In The Composites, Murali Sastry, Vidya Ramakrishnan, Mrunalini Pattarkine, Krishna N. Ganesh
Faculty Works
The formation of composite films of double-stranded DNA and cationic lipid molecules (octadecylamine, ODA) and the hybridization of complementary single-stranded DNA molecules in such composite films are demonstrated. The immobilization of DNA is accomplished by simple immersion of a thermally evaporated ODA film in the DNA solution at close to physiological pH. The entrapment of the DNA molecules in the cationic lipid film is dominated by attractive electrostatic interaction between the negatively charged phosphate backbone of the DNA molecules and the protonated amine molecules in the thermally evaporated film and has been quantified using quartz crystal microgravimetry (QCM). Fluorescence studies …
Where The Wild Wind Blows: Genetically Altered Seed And Neighboring Farmers, Jill Sudduth
Where The Wild Wind Blows: Genetically Altered Seed And Neighboring Farmers, Jill Sudduth
Duke Law & Technology Review
In March 2001, agro-business giant Monsanto won a victory in Canadian Federal Court over Saskatchewan farmer Percy Schmeiser. This case sets international precedent for appropriated seed cases and illustrates the primary concerns American courts must face as they consider Monsanto's prosecution of 22 cases against American farmers.
The Fate Of Gene Patents Under The New Utility Guidelines
The Fate Of Gene Patents Under The New Utility Guidelines
Duke Law & Technology Review
The United States Patent and Trademark Office (PTO) recently finalized its patent utility guidelines. Promulgated by the PTO, the new guidelines will be used by patent examiners in determining whether a claimed invention should be awarded patent protection ;and will be used by patent applicants and attorneys who file patent applications. The guidelines focus primarily on the utility standards for gene and gene fragment patents, an issue that was featured in the PTO's 1999 Revised Interim Utility Guidelines and has been the subject of considerable public debate.
Construction Of A Derivative Of Agrobacterium Tumefaciens C58 That Does Not Mutate To Tetracycline Resistance, Zhao-Qing Luo, Thomas E. Clemente, Stephen K. Farrand
Construction Of A Derivative Of Agrobacterium Tumefaciens C58 That Does Not Mutate To Tetracycline Resistance, Zhao-Qing Luo, Thomas E. Clemente, Stephen K. Farrand
Nebraska Center for Biotechnology: Faculty and Staff Publications
Agrobacterium tumefaciens C58 mutates to tetracycline resistance at high frequency, complicating the use of many broad-host-range cloning and binary vectors that code for resistance to this antibiotic as the selection marker. Such mutations are associated with a resistant gene unit, tetC58, that is present in the genome of this strain. By deleting the tetC58 locus, we constructed NTL4, a derivative of C58 that no longer mutates to tetracycline resistance. The deletion had no detectable effect on genetic or physiological traits of NTL4 or on the ability of this strain to transform plants.
Cationic Surfactant Mediated Hybridization And Hydrophobization Of Dna Molecules At The Liquid/Liquid Interface And Their Phase Transfer, Murali Sastry, Ashavani Kumar, Mrunalini Pattarkine, Vidya Ramakrishnan, Krishna N. Ganesh
Cationic Surfactant Mediated Hybridization And Hydrophobization Of Dna Molecules At The Liquid/Liquid Interface And Their Phase Transfer, Murali Sastry, Ashavani Kumar, Mrunalini Pattarkine, Vidya Ramakrishnan, Krishna N. Ganesh
Faculty Works
Hybridization of complementary oligonucleotides mediated by a cationic surfactant at the water/hexane interface leads to hydrophobic, double-helical DNA which may be readily phase transferred to the organic phase and cast into thin films on solid substrates.
Alternative Oilseeds R&D For Biodiesel Production, Paul Carmody, Howard Carr, Anne Morcom, Graham Walton
Alternative Oilseeds R&D For Biodiesel Production, Paul Carmody, Howard Carr, Anne Morcom, Graham Walton
Research Reports
Biodiesel is widely known an excellent alternative to mineral diesel and has been extensively demonstrated in the EC and the United States. It is a renewable fuel made by reacting 20 parts of Canola oil with one part methanol or ethanol (grain alcohol), injecting hot water through the mixture and allowing to cool. The Biodiesel naturally separates from the water solution, with no further refining or processing required. Biodiesel has the same combustion properties as regular diesel with considerably lower levels of polluting emissions (appendix 1). Bio-diesel has been found to be a cleaner fuel than diesel, resulting in lower …
Kajian Kultur Tisu Dan Aktiviti Sel Carnation (Dianthus Caryophyllus Linn.) Cv. Grenadin, Norfariza A. Kadir
Kajian Kultur Tisu Dan Aktiviti Sel Carnation (Dianthus Caryophyllus Linn.) Cv. Grenadin, Norfariza A. Kadir
Student Works (2000-2009)
Cellular behaviour in primary roots of standard length 11.15 ± 0.33 mm from four-day-old seedlings of Dianthus caryophyllus Linn. cv. Grenadin were studied in vivo and in vitro. Parameters such as mitotic index (MI). chromosome count the ploidy level, the mean cell and nuclear areas and the cell doub ling time (Cdt) were determined from 2 mm segments of root tips. The MI value of the root segment decreased when transferred from in vivo to Murashige and Skoog (MS) medium supplemented with 2.0 mg/l NAA. The mean chromosome count were generally stable during 6 months in culture period with 2n= …
Making Sense Out Of Antisense: The Enablement Requirement In Biotechnology After Enzo Biochem V. Calgene, Matthew D. Kellam
Making Sense Out Of Antisense: The Enablement Requirement In Biotechnology After Enzo Biochem V. Calgene, Matthew D. Kellam
Indiana Law Journal
No abstract provided.
Aquaporin 5-Deficient Mouse Lungs Are Hyperresponsive To Cholinergic Stimulation, Carissa M. Krane, Christopher N. Fortner, Arthur R. Hand, Dennis W. Mcgraw, John N. Lorenz, Susan E. Wert, Jennifer E. Towne, Richard J. Paul, Jeffrey A. Whitsett, Anil G. Menon
Aquaporin 5-Deficient Mouse Lungs Are Hyperresponsive To Cholinergic Stimulation, Carissa M. Krane, Christopher N. Fortner, Arthur R. Hand, Dennis W. Mcgraw, John N. Lorenz, Susan E. Wert, Jennifer E. Towne, Richard J. Paul, Jeffrey A. Whitsett, Anil G. Menon
Biology Faculty Publications
Although aquaporin 5 (AQP5) is the major water channel expressed in alveolar type I cells in the lung, its actual role in the lung is a matter of considerable speculation. By using immunohistochemical staining, we show that AQP5 expression in mouse lung is not restricted to type I cells, but is also detected in alveolar type II cells, and in tracheal and bronchial epithelium. Aqp5 knockout (Aqp5−/−) mice were used to analyze AQP5 function in pulmonary physiology. Compared with Aqp5+/+ mice, Aqp5−/− mice show a significantly increased concentration-dependent bronchoconstriction to intravenously administered Ach, as shown by …
Hawaiian Freshwater Polychaeta: A Potentially Substantial Trophic Component Of Stream Depositional Habitats, M. Eric Benbow, Albert J. Burky, Carl M. Way
Hawaiian Freshwater Polychaeta: A Potentially Substantial Trophic Component Of Stream Depositional Habitats, M. Eric Benbow, Albert J. Burky, Carl M. Way
Biology Faculty Publications
In this paper we report the widespread occurrence of large annelids (Polychaeta: Nereididae) in Hawaiian stream depositional habitats, drawing attention to the lack of knowledge of Hawaiian stream energetics. Specimens of Namalycastis sp. were collected from five Hawaiian Islands from May–July 1995 and from the island of Maui from July–December 1999 and April–July 2000. Most specimens collected were N. hawaiiensis, while two specimens of N. abiuma were collected from a single site on the island of Molokai. Specimens were collected from elevations ranging from 3–240 m; several collections were from sites above at least one major (> 15 m …
Related Enzymatic Activities In Solid-Substrate Fermentation Of Sago Hampas With Pycnoporus Sanguineus, Rifat Ara Matta
Related Enzymatic Activities In Solid-Substrate Fermentation Of Sago Hampas With Pycnoporus Sanguineus, Rifat Ara Matta
Student Works (2000-2009)
Solid substrate fermentation (SSF) of sago pith residue known as 'hampas' with Pycnoporus sanguineus for enzyme production was carried out. Good growth of Pycnoporus sanguineus in SSF was noted on 'hampas' supplemented with 0.38% urea, 0.2% KH₂PO₄ and 0.05% MgSO₄·7H₂O over a period of 30 days. Xylanase, lignin peroxidase and laccase activities were detected in Pycnoporus sanguineus cultures. Maximum xylanase and laccase activities of 5.26U/g of substrate on day 10 of SSF and 14.35U/g on day 15 of SSF of substrate were obtained respectively. The lignin peroxidase activity was less pronounced with an activity of 1.31 U/g of substrate on …
Auditing And Biological Treatment Of Oleochemical Industry Waste, Fauziah Shahul Hamid
Auditing And Biological Treatment Of Oleochemical Industry Waste, Fauziah Shahul Hamid
Student Works (2000-2009)
The utilization of renewable resources particularly from plant-based industries, such as, in the oleochemical sector makes it possible for further expansion of down-stream process products. However, to remain competitive the pollution generated from this industry should not be taken lightly. Implementation of cleaner technology into the oleochemical process will increase the efficiency of resource utilization of the industry, concurrently reducing quantity of waste generated. Waste audit conducted at Cognis Oleochemical (M) (COM) Sdn. Bhd. indicated that the major process-wastes generated by the facility were glycerol residue (GR) from Cognis Rika (M) Sdn. Bhd. (CRM) and wastewater sludge (WWS) from COM …
Immobolisation And Biochemical Characterisation Of A Selected Commercially Available Laccase, Chandra Sundaralingam
Immobolisation And Biochemical Characterisation Of A Selected Commercially Available Laccase, Chandra Sundaralingam
Student Works (2000-2009)
ln this study, laccase from Novo Nordisk was chosen for biochemical characterization and immobilization investigation. The specific aims of this work was to develop optimum conditions for immobilization of laccase by entrapment method using copper alginate and characterize the laccase biochemically. The pH optimum of the crude enzyme extract was 5.5 and was found to be stable over a wide range of pH values. The apparent molecular weight of this enzyme was around 79,000 Daltons. Three peaks of activity (isoenzymes) were obtained from isoelectric focusing of pH values 4.7, 5.2 and 6.0. The optimum pH of the immobilized laccase by …
Isolation, Screening And Characterisation Of Lactic Acid Bacteria Isolated From Local Food Sources, Ahmad Faris Mohd. Adnan
Isolation, Screening And Characterisation Of Lactic Acid Bacteria Isolated From Local Food Sources, Ahmad Faris Mohd. Adnan
Student Works (2000-2009)
126 bacterial isolates were isolated from several local food sources. Out of these, 55 isolates were subsequently identified as lactic acid bacteria i.e. they were gram-positive and catalase negative. These 55 isolates were put through gel plug test to distinguish between homofermentative and heterofermentative isolates. 16 of the 55 lactic acid bacteria isolates were found to be homofermentative. From the 16 homofermentative isolates, seven were chosen on the basis of origin and sugars used in the enrichment process for preliminary physiological characterisation. Several conditions were chosen such as variable temperature, lactic acid tolerance, NaCl concentration and initial pH These serve …
Fixed Bed Biosorption Of Cu(Ii) By Immobilized Biomass Of Sargassum Baccularia, Kong Fei Tan
Fixed Bed Biosorption Of Cu(Ii) By Immobilized Biomass Of Sargassum Baccularia, Kong Fei Tan
Student Works (2000-2009)
The primary objective of this study was to investigate the feasibility of using the immobilized biomass of Sargassum buccularia. a brown marine macro algae. to remove and recover copper ions in a fixed bed reactor by passive adsorption. This is commonly referred to as biosorpliun. Inactivated biomass of S. baccularia were chemically modified b) immobilizing it onto polyvinyl alcohol (PVA} as a support matrix. Spherical gel beads that were produced in this manner were subjected to mass transfer and equilibrium studies. The biosorption of copper is a bi-phasic process. with an initial fast phase for the first 2 hours followed …