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Articles 1 - 16 of 16
Full-Text Articles in Biotechnology
Cultivation Of Arthrospira Platensis (Spirulina) In Food-Based Industrial Wastewater For High-Yield Phycocyanin Extraction, Pavithira Sathinathan
Cultivation Of Arthrospira Platensis (Spirulina) In Food-Based Industrial Wastewater For High-Yield Phycocyanin Extraction, Pavithira Sathinathan
Student Works (2020-2029)
Arthrospira platensis (Spirulina) is a filamentous cyanobacterium valued for its nutritional profile, particularly the pigment–protein phycocyanin, with potent antioxidant and anti-inflammatory properties. Despite its industrial significance, large-scale commercialization remains constrained by high cultivation costs and inefficient extraction methods. This study investigated the use of food-based industrial wastewater as an alternative nutrient medium for Spirulina cultivation, aiming to reduce production costs, enhance phycocyanin yield, and support sustainable wastewater remediation. Three types of food-based wastewater with different nutrient composition (WW1, WW2, WW3) was diluted with Kosaric medium (1:1) and used for Spirulina cultivation. The highest biomass concentration was achieved in WW2 (1.93 …
Mycoremediation And Fungi-Assisted Phytoremediation Of Heavy Metal Contaminated Landfills Soil, Auwalu Hassan
Mycoremediation And Fungi-Assisted Phytoremediation Of Heavy Metal Contaminated Landfills Soil, Auwalu Hassan
Student Works (2020-2029)
The research is aimed to study the bioremediation of heavy metal landfill leachate contaminated soil using consortia of indigenous filamentous fungi and indigenous plants. Thirteen identified fungal isolates were used to formulate the consortia for mycoremediation. The mycoremediation was carried out in three phases, namely laboratory trial 1 using five consortia, laboratory trial 2 with varied concentrations of inoculum, and field application. The fungi-assisted phytoremediation was carried out in two phases: laboratory trials using Alocasia calidora, Prosopis juliflora, and Jatropha sp. and field trial using A. calidora. The analyses conducted included soil physicochemical and biological parameters, Fourier-transform infrared spectroscopy (FTIR) …
Resource Characterization And Utilization Of Lepironia Articulata (Retz.) Domin At Kg. Beris Tok Kuand Kg. Beting Lintang, Terengganu, Shoma Tani
Student Works (2020-2029)
This research focused on how handicrafts could contribute to sustainable community development with natural resource management. This research aims to characterize Lepironia articulata as a resource by taxonomy and distribution patterns, examine its utilization through group and semi-structured interviews with ten local residents who got involved in handicraft productions at two selected villages in Setiu Wetlands of Terengganu state and identify their capacity development opportunities by following a guideline provided by United Nations Development Programme. This research clarified that the height of Lepironia articulata in Setiu Wetlands was shorter than the records of the other description and the other site …
Antibacterial Action Of Graphene Oxide Towards Bacteria And Its Toxicological Effects On Human Epidermal Keratinocytes, Thiruchelvi Pulingam
Antibacterial Action Of Graphene Oxide Towards Bacteria And Its Toxicological Effects On Human Epidermal Keratinocytes, Thiruchelvi Pulingam
Student Works (2020-2029)
The antibacterial nature of graphene oxide (GO) has stimulated wide interest in the medical field. Although the antibacterial activity of GO towards bacteria has been well studied, a deeper understanding of the mechanism of action of GO is still lacking. The objectives of the study were to characterize the physicochemical properties of GO, to determine the antibacterial and antibiofilm activity and the mechanistic action of GO against Gram-positive Staphylococcus aureus and Enterococcus faecalis and Gram-negative Escherichia coli and Pseudomonas aeruginosa, to determine the synergistic behaviour of GO with selected antibiotics against bacterial cells in suspension and biofilm and to determine …
Performance Analysis Of Bacterial Genome Assemblers Using Illumina Next Generation Sequencing Data, Nur ‘ Ain Mohd Ishak
Performance Analysis Of Bacterial Genome Assemblers Using Illumina Next Generation Sequencing Data, Nur ‘ Ain Mohd Ishak
Student Works (2020-2029)
The advancement of next generation sequencing (NGS) technology has revolutionized the field of genomic and genetic studies. As compared to conventional methods, NGS generate comprehensive genomic data at a fraction of the cost with a higher percentage of accuracy. One of the processing and analyzing NGS data is genome assembly. De novo assembly is a process of assembling short reads into contiguous sections of sequence without a reference which is different with conventional mapping technique. De Bruijn graph is one of the assembly algorithms that are widely used for short reads sequences produced from NGS platforms. In this study, the …
Non-Invasive Tests For The Detection Of Nasopharyngeal Carcinoma, Mohan Sivanesan Vijaya
Non-Invasive Tests For The Detection Of Nasopharyngeal Carcinoma, Mohan Sivanesan Vijaya
Student Works (2020-2029)
Nasopharyngeal carcinoma (NPC) is a malignancy that arises in the epithelium of the nasopharynx. Diagnosis is often delayed due to inaccessibility of primary tumour site which leads to inaccurate biopsy. The pathogenesis of NPC is linked to the Epstein-Barr virus (EBV) and studies have shown the employability of plasma EBV DNA for the detection and monitoring of NPC. MicroRNAs (miRNA) are a class of small non-coding RNA that are dysregulated in various cancers and have been extensively studied as biomarker due to their stability in various biospecimens. The aim of this project is to evaluate the load of EBV DNA …
Differentiation Propensity, Safety, And Therapeutic Potential Of Mesenchymal Stem Cells Of Dental Origin, Musa Sabri
Differentiation Propensity, Safety, And Therapeutic Potential Of Mesenchymal Stem Cells Of Dental Origin, Musa Sabri
Student Works (2020-2029)
Introduction: A new area in medical research has emerged with the discovery of mesenchymal stem cells (MSCs) and their ability to differentiate into other cell types. Specifically, these cells are found in various tissues and have been utilized in the field of regenerative medicine to support tissue repair as well as in cell replacement. Lately, MSCs of dental origin have been the main players used for regenerative purposes although subtle differences based on their tissue source separate them. Objectives: This study aims to determine the differential propensity, safety, and potential therapeutic applications of dental-derived MSCs. This involves examining various aspects …
Modeling, Fabrication And Characterization Of Coated Calcium Phosphate Scaffolds Produced By 3d-Printing For Tissue Engineering Application, Touri Maria
Student Works (2020-2029)
A fully interconnected 3-dimensional scaffold with pre-determined dimensions and porosity can be attained by design-dependent rapid prototyping techniques which possess precise control over the internal and external architecture of the scaffolds thus they can overcome the problems associated with the process-dependent classical approaches. Interruption of vascular flow with fracture or surgical osteotomy results in a transient hypoxic gradient within the wound and subsequent tissue necrosis. Tissue engineering scaffolds with oxygen generating elements have shown to be able to increase the level of oxygen and cell survivability. In this study, biphasic calcium phosphate (BCP) scaffolds with the composition of 60% hydroxyapatite …
Optimisation Of Biomass And Lipid Production Of A Tropical Thraustochytrid Aurantiochytrium Sp. Umacc-T023 In Submerged-Liquid Fermentation For Large-Scale Biodiesel Production, Sohedein Mohamad Nor Azzimi
Optimisation Of Biomass And Lipid Production Of A Tropical Thraustochytrid Aurantiochytrium Sp. Umacc-T023 In Submerged-Liquid Fermentation For Large-Scale Biodiesel Production, Sohedein Mohamad Nor Azzimi
Student Works (2020-2029)
A tropical thraustochytrid, Aurantiochytrium sp. UMACC-T023, was optimised for high biomass and lipid production in submerged-liquid fermentation (SLF). Biomass and lipid production were optimised based on glucose, polypeptone, and yeast extract concentration using response surface methodology (RSM). In RSM, the applied central composite design (CCD) showed that the optimisation model was significant for all variables studied. Yeast extract and polypeptone were associated with significant effects in UMACC-T023 biomass production with p < 0.05. The model was validated by employing the optimised media composition in shake flasks and in 1.4-L stirred-tank bioreactors. The optimised media composition for both biomass and lipid production was 10 g L-1 glucose, 15.08 g L-1 polypeptone, and 13.56 g L-1 yeast extract. Biomass production in the bioreactor increased 2.12-fold compared with the shake flask culture utilising the same optimised media composition. This result demonstrated that the optimized media composition can be utilised for large-scale lipid production of UMACC-T023 for potential biodiesel feedstock as it also fulfilled the international standards for biodiesel.
Suspended Carbon Nanowire Biosensor For Rapid And Label-Free Salmonella Detection, Thiha Aung
Suspended Carbon Nanowire Biosensor For Rapid And Label-Free Salmonella Detection, Thiha Aung
Student Works (2020-2029)
Carbon, the building block life, is rapidly becoming the building block of nextgeneration electronics and sensor materials. Of many ways to handle nanocarbon materials, Carbon Microelectromechanical Systems (C-MEMS) emerges as a unique way for top-down fabrication of three-dimensional carbon micro to nanostructures. In this work, the use of C-MEMS techniques in nanowire biosensor fabrication is explored. Two main hindrances in the use of C-MEMS carbon structures for biosensing lie in miniaturization to nanoscale sensor material and inertness of as-fabricated carbon. This dissertation presents ways to overcome these limitations. First, miniaturization to patterned sub-100 nm carbon nanowires was achieved by optimization …
Graphene Oxide Gold Nanostructure Based Surface Enhanced Raman Scattering Dna Biosensor For The Detection Of Meat Species, Khalil Md. Ibrahim
Graphene Oxide Gold Nanostructure Based Surface Enhanced Raman Scattering Dna Biosensor For The Detection Of Meat Species, Khalil Md. Ibrahim
Student Works (2020-2029)
Authentication, detection and quantification of the ingredients, and adulterant in the food, meat and meat products are of high importance in current days. However, the conventional meat species detection techniques based on lipid, protein and DNA biomarkers have been confronting challenges due to the poor selectivity, sensitivity, and unsuitability for processed food products or complex food matrices. Hence, nanoparticle based DNA biosensing strategies have attracted the most interests and considered as one of the best alternatives to conventional strategies. Among these, surface enhanced Raman scattering (SERS) has gained the substantial acceptance as an excellent, fast and ultrasensitive sensing technique due …
Polyhydroxyalkanoates For Innovative Electrodes And Proton Exchange Membrane Modification In Microbial Fuel Cell, Abdul Azeez Olayiwola Sirajudeen
Polyhydroxyalkanoates For Innovative Electrodes And Proton Exchange Membrane Modification In Microbial Fuel Cell, Abdul Azeez Olayiwola Sirajudeen
Student Works (2020-2029)
The increase in global energy demand due to increasing population and industrialization demands renewable and environmental-friendly alternatives. Energy from fossil fuel are non-renewable, depleting and detrimental from environmental perspectives. Alternative energy, green and renewable such as hydrogen fuel, biodiesel, bioethanol, microbial fuel cell and many more have been extensively investigated. One possible solution lies with non-combustion method such as microbial fuel cell. A microbial fuel cell is a sustainable and environmental-friendly device that combines electricity generation and wastewater treatment through metabolic activities of microorganisms. However, low power output from inadequate electron transfer to the anode electrode hampers its practical implementation. …
Mixed Culture Polyhydroxyalkanaotes (Pha) Production Using Crude Glycerol As Carbon Source, Mohamad Fauzi Ainil Hawa
Mixed Culture Polyhydroxyalkanaotes (Pha) Production Using Crude Glycerol As Carbon Source, Mohamad Fauzi Ainil Hawa
Student Works (2020-2029)
Polyhydroxyalkanoates (PHA) is a biopolymer that has the prospect of becoming a preferred renewable and environmentally friendly resource with various applications including in manufacturing and medicine. Intensive studies have been carried out to find the most practical and economical method for PHA production because current commercial production of PHA is stringent and extremely costly. The aim of this study is to enrich PHA-accumulators with high PHA production capabilities by evaluating the stability of the enrichment process and by observing the effect of organic loading rate (OLR) on the production potential. In this study, PHA-accumulators were cultivated using activated sludge with …
In Vitro Regeneration Of Dioscorea Alata With Anthocyanin And Antimicrobial Activity, Abdullah Sakinah
In Vitro Regeneration Of Dioscorea Alata With Anthocyanin And Antimicrobial Activity, Abdullah Sakinah
Student Works (2020-2029)
An efficient protocol was developed for rapid propagation and regeneration of the Dioscorea alata L. locally known as ‘ubi badak’ because of their rhinoceros-shaped tubers. In the present study, direct and indirect regeneration were induced to produce plantlets of Dioscorea alata L. For direct regeneration explants (leave, stem and node) were cultured on MS media supplemented with various combinations and concentrations of BAP and NAA to induce microshoots and roots formation. The optimum medium for microshoots formation was MS medium supplemented with 1.0 mg/l BAP and 0.5 mg/l NAA with the number of microshoot is 23.07±0.44 from node explant. While …
Hydrolysis Of Palm Oil Mill Effluent Using Enzymes From Spent Mushroom Substrate Of Pleurotus Pulmonarius (Fr.) Quel, Mat Yunan Nurul Anisa
Hydrolysis Of Palm Oil Mill Effluent Using Enzymes From Spent Mushroom Substrate Of Pleurotus Pulmonarius (Fr.) Quel, Mat Yunan Nurul Anisa
Student Works (2020-2029)
Mushroom cultivation and palm oil industry in Malaysia have contributed to the large volumes of lignocellulosic residues. Lignocellulolytic enzymes profiles (lignin peroxidase, laccase, xylanase, endoglucanase, and β-glucosidase) of Pleurotus pulmonarius (parents strains UMP001 and UMP 002, and the hybrid UMH004) during growth in sawdust substrate bags were investigated. The enzymes extracted from the spent mushroom substrate (SMS) of the strain with the highest enzymes productivity was used to hydrolyse palm oil mill effluent (POME). Optimization of parameters for POME hydrolysis to release reducing sugar was conducted using central composite design (CCD) of response surface methodology (RSM). The potential of hydrolysed …
Morphology, Molecular Characterization And Habitat Preference Of Harmful Benthic Dinoflagellate Gambierdiscus (Dinophyceae) In Malaysia, Nurin Izzati Mustapa
Morphology, Molecular Characterization And Habitat Preference Of Harmful Benthic Dinoflagellate Gambierdiscus (Dinophyceae) In Malaysia, Nurin Izzati Mustapa
Student Works (2020-2029)
Ciguatera fish poisoning (CFP) is a type of illness that causes human intoxication after consuming contaminated coral fishes. The neurotoxins, ciguatoxins, are produced by species of Gambierdiscus, one of the harmful benthic dinoflagellates. Identification of harmful dinoflagellate species is important to gain further insights into the global dispersion. In this study, morphological characteristics of species in the genus Gambierdiscus and their habitat preferences were investigated. Field sampling was undertaken at Pulau Rawa, Terengganu and Pulau Sibu, Johor. Single cells of Gambierdiscus were isolated and clonal cultures were established. Morphology of Gambierdiscus was examined by using light and scanning electron microscopes. …