Biotechnology Commons^™

Electroceuticals In Neuromodulation: Mechanisms, Clinical Applications, And Future Directions, Albashir Tahir, Nura Bello

AUIQ Complementary Biological System

Electroceuticals have emerged as an innovative therapeutic approach that employs targeted electrical stimulation to modulate neural circuits and restore physiological balance. Unlike conventional pharmacological treatments, which act through systemic biochemical pathways, electroceuticals enable precise spatial and temporal control of neural activity. The rapid proliferation of electroceutical devices across clinical and investigational settings, combined with accelerating advances in artificial intelligence, closed-loop engineering, and bioelectronic interface design, has generated an urgent need for rigorous, critically appraised synthesis to guide evidence-based clinical adoption and inform future research priorities. This review addresses the rapidly expanding field of bioelectronic medicine by providing a critical synthesis …

First Photographic Record Of A Pale-Colored Wild Boar (Sus Scrofa) Consistent With Leucism In The Zagros Mountains, Iraqi Kurdistan, Bahez F. Ali, Hana A. Raza, Nabaz Horeni

AUIQ Complementary Biological System

Pigmentation anomalies in wild mammals are rare and poorly documented in wild boar (Sus scrofa) populations. Leucism, characterized by partial loss of melanin while retaining normal eye pigmentation, represents one of the least frequently reported coloration anomalies in the species. During a camera-trap survey in Bamo Mountain, Zagros Mountains of Iraqi Kurdistan, an unusually pale-colored wild boar consistent with leucism was recorded. The individual exhibited cream to light-blond pelage with retained darker pigmentation on the snout and distal limbs, while the eyes remained normally pigmented. Its morphology and behavior were otherwise consistent with those of a typical wild …

Meningioma Detection From Mri: A Comparative Study Of Deep Learning Models, A. H. Doha, Sandi Jennifer, Fatima Alabdaly

AUIQ Complementary Biological System

This study compares several deep learning models including DenseNet20, CNN, ResNet50, VGG19, EfficientNet-B3, MobileNetV2, NASNetMobile, Xception to automatically classify brain meningiomas from MRI scans. A public dataset was used to evaluate the proposed model. All models were trained, validated, and tested on this dataset. Because meningiomas are common and manual reads, the goal is to speed and standardize diagnosis. Our main contribution is pairing a high-accuracy classifier with deep learning models. Among all models, DenseNet201 performed best, reaching 0.991% accuracy and reliably separating tumorous from non-tumorous MRIs. Future work will expand the dataset and incorporate stronger segmentation to further boost …

Diabetes Mellitus Exacerbates Covid-19 Severity And Prolongs Recovery: A Clinical Study From Southern Iraq, Hussein Ali Hussein Al-Hchaimi, Mohammad Ali Hassan Jassim, Mustafa Abbass, Shahab Abdulla, Ralela Makline

AUIQ Complementary Biological System

Diabetes mellitus (DM) constitutes one of the most consequential comorbidities shaping the clinical trajectory of Coronavirus Disease 2019 (COVID-19), operating through intersecting mechanisms of chronic inflammation, endothelial injury, and immunosuppression that collectively amplify viral pathogenicity. This study investigated the impact of diabetes type on COVID-19 symptom severity, hospitalization duration, and recovery time among patients in Nasiriyah City, southern Iraq — a region substantially underrepresented in the global DM–COVID-19 literature. A descriptive cross-sectional study was conducted across healthcare facilities in Nasiriyah City from 2023 to 2024. A total of 150 hospitalized adult patients carrying confirmed diagnoses of both COVID-19 and type …

Effect Of Spry Of Potassium Ratio And Cycocel On Physiological Traits Of Maize (Zea Mays L), Asmaa Mohammed Hussein, Eabdallah Yasin Ali

AUIQ Complementary Biological System

The aim of this work was to investigating the effect of foliar application of potassium (K) and the growth regulator Cycocel (CCC) on the physiological traits of maize (Zea mays L). The experiment was designed using a split-plot arrangement within a randomized complete block design (RCBD) with three replicates. The treatments included foliar application of potassium at concentrations of 500, 1000, and 1500 mg.L^–1, as well as three concentrations of the growth regulator Cycocel (0, 150, and 200 mg.L^–1). The results indicated a significant increase in Protein (P), phosphorus, and carbohydrate contents at the concentration of …

Chronotropic Response To Intratracheal Versus Intravenous Atropine In Anesthetized Adult Patients: A Randomized Controlled Trial, Ammar H. Mahdi, Majid Alhamaidah, Myasar J. Mohammed, Hussein Ali Hussein, Hussein Alkhfaji

AUIQ Complementary Biological System

Atropine is a commonly used anticholinergic agent in anesthetic practice, administered primarily to counteract bradycardia. Rapid treatment of intraoperative bradycardia is clinically critical, as delays may lead to hemodynamic compromise. This study aimed to compare the onset, magnitude, and duration of the chronotropic response to atropine administered via the intravenous (IV) versus intratracheal (IT) route in anesthetized adult patients. A prospective, single-blind, randomized controlled study was conducted on 60 adult patients classified as American Society of Anesthesiologists (ASA) physical status I-II, scheduled for elective peripheral surgery under general anesthesia. Patients were randomly allocated into three equal groups (n = 20 …

Bioactive Constituents And Pharmacological Activities Of Curcuma Zedoaria: A Mini-Review, Abdulmutalib Allaq, Muneer M. Saleh Mohammed Saleh Alsayadi, Mustapha Salihu, Hasan M. Agha, Amena Hassan Hassan Gheeth, Fatimah Salim, Norrizah Jaafar Jaafar Sidik

AUIQ Complementary Biological System

Curcuma zedoaria Rosc. (white turmeric) is a rhizomatous medicinal plant in the Zingiberaceae family, widely used in traditional Asian medicine. In recent years, increasing scientific attention has focused on its diverse pharmacological properties and bioactive constituents. This mini review summarises current knowledge of the phytochemical composition and biological activities of C. zedoaria, with particular emphasis on its antimicrobial, antioxidant, anti-inflammatory, and anticancer effects. Phytochemical investigations using analytical techniques such as GC–MS and HPLC have revealed the presence of numerous bioactive compounds, including sesquiterpenes (example, germacrone, curzerenone, and curdione) and curcuminoids, which contribute to its therapeutic potential. Experimental studies demonstrate …

Evaluation Of Circulating Hpg80, Ca15-3, Estrogen And Progesterone As Biomarkers In Breast Cancer Patients, Safa Khaldoon, Emad Yousif, Khawla A. Kasar, Muna Bufaroosha, Rahimi Yusop

AUIQ Complementary Biological System

It is very important to find reliable biomarkers for early detection and monitoring of treatment response because breast cancer is still one of the most common cancers in women around the world. The goal of this study was to find out how clinically important different biochemical markers are in Iraqi women with breast cancer. Some of these signs are progesterone (PG), oestrogen (E2), cancer antigen 15-3 (CA15-3), and circulating progastrin (hPG80). There were 100 women in this study, and they were all between the ages of 20 and 70. There were three groups of people who took part: a healthy …

Synergistic Endocytic Receptor Ligand Receptor Protein 2 In T2dm, Wafaa Raji Alfatlawi

AUIQ Complementary Biological System

Purpose: The glycoprotein molecule known as megalin is present on the proximal renal tubular epithelial cells. With an emphasis on megalin and cubilin levels in T2DM and IR patients, an area that obviously needs more research, this study attempts to give an outline of current knowledge of megalin function in relation to vitamin D and its metabolite (vitamin D receptor and vitamin D binding protein). Materials and Methods: This was a case control comparative study conducted at a endocrine and diabetes center in AL-Imamain Kadumain teaching hospital in Baghdad-Iraq. Study subjects were divided into three groups: 25 with T2DM with …

Aquifer Characteristics And Groundwater Flow Modeling For Sustainable Water Resources Development And Planning Using Modflow Software In India, Ravi Sharma

AUIQ Complementary Biological System

MODFLOW is one of the most commonly used numerical models for simulating groundwater flow. Its structured data design and compatibility with GIS tools make it suitable for groundwater assessment and planning. Groundwater forms an important part of the hydrological cycle and occurs within the pore spaces of sedimentary rocks or within fractures in hard rock terrains. Although its distribution beneath the surface is not always uniform or predictable, it is still considered one of the cleanest, most accessible, and quickly available freshwater sources. Numerical groundwater models help convert complex subsurface processes into simplified relationships that describe flow behavior. Even though …

Targeting Hypothalamic Oxidative Stress And Neuroinflammation: A Novel Neuroprotective Role For Annona Muricata Seed Extract In Aluminium- Induced Alzheimer-Like Neurodegeneration, O. A Bamgbose, O. D Akanji, P. B Fakunle, D. O Taiwo-Ola, K. O Odubela, E. O Olayemi, B. A Akanbi, B. M David

AUIQ Complementary Biological System

Alzheimer's disease (AD) is increasingly recognized as a multisystem neurodegenerative disorder involving oxidative stress and neuroinflammation beyond classical hippocampal pathology. The hypothalamus, a key regulator of metabolic and neuroendocrine homeostasis, remains comparatively underexplored in experimental AD models. This study investigated the effects of aqueous Annona muricata seed extract (SSE) on hypothalamic oxidative injury in an aluminium chloride (AlCl₃)-induced Alzheimer's disease–like model in Wistar rats. Adult Wistar rats of both sexes were randomly assigned to five groups (n = 5): control, AlCl₃ (100 mg/kg), SSE alone (200 mg/kg), AlCl₃ + SSE, and AlCl₃ + donepezil (10 …

Synergistic Microbiome-Peptidome Therapeutics: Exploring Lactobacillus Reuteri Dsmz 17648 And Stem Cell-Derived Peptides For Immunomodulation And Tissue Repair Across Diseases, Hasan M. Agha, Mohammed A. Abdalqader, Abdullah Asad Siddiqui, Shafiq Aazmi, Jantson Hoh, Oh Chin Kin Michelle, Sabaa M. Agha, Amjad Abdulhadi Mohammed, Muneer Mohammed Saleh Alsayadi

AUIQ Complementary Biological System

Chronic inflammatory and degenerative disorders are driven by interconnected immune dysregulation, metabolic instability, epithelial barrier disruption, and impaired tissue repair, limiting the durability of conventional single-target therapies. The global rise in chronic inflammatory, metabolic, and age-related degenerative diseases underscores an urgent need for multi-dimensional therapeutic strategies that move beyond isolated molecular targets. Despite rapid advances in microbiome science and regenerative medicine, these fields have largely evolved in parallel, with limited integration at the translational level. Emerging evidence identifies the gut microbiome as a central regulator of systemic immunometabolic homeostasis through microbial metabolites, barrier integrity modulation, and immune-cell education. In parallel, …

Perioperative Fluid Management In Cardiac Surgery: Contemporary Evidence And Clinical Controversies, Hussein Ali Hussein Al-Hchaimi, Hussein Alkhfaji, Majid Fakhir Al-Hamaidah, Mohammad Ali Hassan Jassim, Ammar Hoom Mahdi, Fatima Al-Sharwood, Sunder Etta

AUIQ Complementary Biological System

Perioperative fluid therapy is a cornerstone of anesthetic management in cardiac surgery, where both hypovolemia and hypervolemia are associated with increased morbidity, forming a ``U-shaped'' relationship with outcomes. This narrative review synthesizes evidence from peer-reviewed literature (2000–2024) identified via PubMed, Scopus, and the Cochrane Database, focusing on randomized trials, meta-analyses, and guidelines for adult cardiac surgery. A central debate persists regarding fluid choice. Current evidence supports the preferential use of balanced crystalloids over normal saline, as large-volume saline is linked to hyperchloremic acidosis and reduced renal perfusion. Colloids like albumin and hydroxyethyl starch (HES) offer efficient volume expansion but require …

Interdisciplinary Management Of Severe Pediatric Subglottic Stenosis: A Case Report Of Endoscopic Balloon Dilation Under Shared Airway Conditions, Margaretha Gunawan, Syahrial Marsintha Hutauruk, Fauziah Fardizza, Christopher Kapuangan, Mikhael Yosia

AUIQ Complementary Biological System

Pediatric acquired subglottic stenosis is a high-risk airway condition that requires close coordination between anesthesiology and otorhinolaryngology teams, particularly during endoscopic interventions performed under shared-airway conditions. This report describes the interdisciplinary management and anesthetic–surgical coordination in a child with severe acquired subglottic stenosis undergoing endoscopic balloon dilation, highlighting key decision points and airway management strategies. A 2-year-old boy with a history of prolonged and repeated endotracheal intubations presented with persistent dyspnea and noisy breathing, consistent with fixed extrathoracic airway obstruction. The case was reviewed in a multidisciplinary pediatric difficult-airway meeting, and operative management consisted of endoscopic airway evaluation and balloon …

Waste-To-Energy Innovations And Advances In Hydrothermal Carbonization, Microwave, And Pyrolysis Processes: A Review, Ali Mohammed Saleh, Noah Mohammed Saleh, Mahmod A. Abdulqader, Hadi Hamdi Mahdi, Jafar Keighobadi, Omar K. Ahmed, Khalil Farhan Yassin, Azil Bahari Bin Alias, Omar Abed Habeeb, Ibrahim Awad Mohammed

AUIQ Complementary Biological System

The accelerating global generation of municipal solid waste, coupled with escalating energy demands, presents one of the most pressing sustainability challenges of the 21st century. Conventional waste disposal pathways, such as landfilling and incineration, exacerbate environmental degradation and resource loss. In response, thermochemical technologies—specifically hydrothermal carbonization (HTC), microwave-assisted processing, and pyrolysis—have emerged as promising strategies for waste valorization and renewable energy recovery. This review critically examines recent advancements in these technologies, emphasizing their roles in converting diverse waste streams into high-value energy carriers and carbon-rich materials. Comparative analysis reveals that HTC operates efficiently under subcritical water conditions, producing hydrochar with …

Discussion Of The Parameters Affecting The Boiling Point In The Distillation Test Of The Kerosene Product, Semaa I. Khaleel, Ahmad A. Aabid, Islam K. Saeed, Muneef Mahjoob Mohammed, Ali Mohammed Saleh, Ibrahim Awad Mohammed, Omar Abed Habeeb, Mahmod A. Abdulqader

AUIQ Complementary Biological System

Currently the kerosene fuel is very important for use in the heating, cooking, and fuel of the jet engines. The study aims effected of mixing different lite bit and same of gasoil to three different type of kerosene samples, and study the initial boiling point (IPB) during of distillation test. This study focused on targeting the IPB of the kerosene samples by finding the specific gravity (Sp.gr) test, the American Petroleum Institute (API) degree, and distillation test. However, these samples of kerosene were characterized and labeled (kero-01, kero-02, and kero-03, respectively) before the dealing processes, while the samples after the …

Comparative Antibacterial Efficacy Of Povidone-Iodine, Citric Acid, And Starch: A Study Of Combined Activity And Interference Effects Against Clinically Relevant Bacteria, Falah Hasan Obayes Al-Khikani, Mustafa Mutar Trrad, Ali Abedulameer Alhusayni

AUIQ Complementary Biological System

Povidone-iodine and citric acid are widely used antimicrobial agents. However, data on their comparative efficacy and the functional outcomes of their combination, particularly regarding the influence of common excipients like starch, is limited. Understanding these interactions is crucial for optimizing antiseptic formulations. This study aimed to evaluate and compare the antibacterial activity of povidone-iodine, citric acid (5% and 20%), and starch (5% and 20%), both individually and in combination, against clinical isolates of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The antibacterial activity of the agents was assessed using an agar well diffusion assay. Mean inhibition zone …

Recent Advances In The Pharmacological Properties Of Scutellarin: Mechanistic Insights And Therapeutic Potential, Hind A. Satar, Emad Yousif, Ahmed Ahmed, Muna Bufaroosha

AUIQ Complementary Biological System

Scutellarin, a flavonoid glycoside primarily derived from Scutellaria baicalensis, has garnered increasing scientific interest for its multifaceted pharmacological properties. This review summarizes recent advances in our understanding of scutellarin's therapeutic effects, including its antioxidant, anti-inflammatory, neuroprotective, cardioprotective and anticancer activities. Emphasis is placed on elucidating its molecular mechanisms of action, such as modulation of the NF-κB, Nrf2, and PI3K/Akt pathways, and its role in regulating oxidative stress, inflammation, and apoptosis. Additionally, we discuss formulation innovations, including nanoparticle and liposomal delivery systems, aimed at overcoming scutellarin's poor oral bioavailability and enhancing therapeutic performance. Key limitations in current research …

Evaluation Of Occupational Health And Safety Knowledge, Attitudes, And Practices Of Workers At North Refineries Company, Wesam Awad Hassn, Zeena N. Abdulrahman

AUIQ Complementary Biological System

Safety is crucial in the oil and gas refinery industry for production and distribution. Companies must ensure a workplace free from common injuries and protected against serious incidents. This paper evaluates employees’ knowledge, attitudes, practices, and workplace environment at North Refineries Company (Baiji). A descriptive cross-sectional study was conducted from September 10, 2024, to September 20, 2025, involving 480 employees (378 workers and 102 managers). Data were collected through face-to-face interviews and analysed using SPSS version 24. North Refineries Company (Baiji). workers scored 72.49 % on general knowledge and 96.83% on attitudes, but only 53.97% on safe behaviour. Division managers …

Prevention Of Postoperative Nausea And Vomiting In Early Recovery: A Comparative Study Of Ondansetron And Metoclopramide In Adults Undergoing Elective Lower Abdominal Surgery, Majid Fakhir Al-Hamaidah, Ali Ihsan Abdul Mahdi, Maytham Alaa Shahid, Sajjad Salih Rasan, Lina M. Shaker, Shahab Abdulla, Ralela Makline

AUIQ Complementary Biological System

Postoperative nausea and vomiting (PONV) remain common complications following surgery, despite the availability of various prophylactic antiemetic agents. This study aimed to compare the effectiveness of ondansetron and metoclopramide in preventing PONV in patients undergoing elective lower abdominal surgery under general anesthesia. In this double-blind, randomized controlled trial, 80 adult patients were equally allocated into two groups: one receiving 0.1 mg/kg of intravenous ondansetron and the other 0.2 mg/kg of intravenous metoclopramide at the end of surgery. The incidence, frequency, and need for rescue antiemetics were evaluated over 24 hours postoperatively. The overall incidence of nausea was higher in the …

Prevalence And Characteristics Of Prescription Errors In Community Pharmacies In Mbarara City, South Western Uganda, Tadele Mekuriya Yadesa, Ashaba Comfort, Komukyeya Esther Marvel, Namakula Angela, Tikolu Hope Nancy, Narayana Goruntla, Sarad Pawar Naik Bukke, Bontu Aschale Abebe, Efrata Ashuro Shegena

AUIQ Complementary Biological System

A prescription error is a failure in the prescription writing process that results in a wrong instruction about one or more of the standard features of a prescription. Most adverse drug events are preventable through promoting rational drug use; primarily by mitigating the outstanding high burden of prescribing errors. The main aim of this study is to assess the prevalence and characteristics of prescription errors in the community pharmacies in Mbarara, Uganda. A cross-sectional study was conducted in selected community pharmacies in Mbarara City, South Western Uganda. Consecutive sampling of all prescriptions availed at the selected pharmacies was conducted until …

Sheep Umbilical Cord Mesenchymal Stem Cells: Biological Characteristics, Ethical Considerations, And Translational Applications, Hasan M. Agha, Mohammed A. Abdalqader, Oh Chin Kin Michelle, Sabaa M. Agha, Jantson Hoh, Abdulmutalib Alabeed Allaq, Amjad Abdulhadi Mohammed, Muneer Mohammed Saleh Alsayadi

AUIQ Complementary Biological System

Mesenchymal stem cells (MSCs) are widely used in regenerative medicine due to their self-renewal capacity, multilineage differentiation potential, and paracrine activity. Limitations associated with the sourcing and scalability of human MSCs have increased interest in xenogeneic alternatives, particularly sheep umbilical cord–derived MSCs (sUC-MSCs). These cells display high proliferative capacity, stable karyotypes, and a typical MSC immunophenotype (CD44, CD73, CD90, CD105), with low basal immunogenicity. sUC-MSCs exhibit osteogenic, chondrogenic, and adipogenic differentiation potential and secrete angiogenic and immunomodulatory factors, including VEGF, HGF, IGF-1, TGF-β, and IL-10. Owing to their biological similarities to human MSCs and accessibility from perinatal tissue, …

Neuroprotective Effects Of Aqueous Extract Of Bryophyllum Pinnatum Against Lead Acetate Induced Damage In The Cerebellum Of Rats, O. A. Bamgbose, O. D. Akanji, E. O. Olayemi, D. O. Taiwo-Ola, K. O. Odubela, B. A. Akanbi, P. B. Fakunle

AUIQ Complementary Biological System

Lead is a persistent environmental toxin with pronounced neurotoxic effects, particularly on the central nervous system. This study evaluated the impact of lead acetate on the cerebellar cortex of adult Wistar rats and assessed the neuroprotective effects of aqueous Bryophyllum pinnatum extract. Twenty adult Wistar rats (180–220 g) were randomly assigned to four groups (n = 5): Control (distilled water), T1 (0.075 mg/kg lead acetate), T2 (100 mg/kg B. pinnatum), and T3 (lead + B. pinnatum). Treatments were administered orally for 21 days. Cerebellar tissues were processed for biochemical and histological analysis, and data were analyzed using GraphPad Prism v10.1.Lead …

Cytological Changes In Buccal Mucosa Among Yemeni Qat Chewers In Hadhramout Governorate: A Comparative Cross-Sectional Study, Saleh H. Ben Sumaidea, Hassan Pyar, Abdullah O. Bin Nashwan, Abdullah M. Bin Fadhl, Abeer A. Marabi, Ahmed A. Al-Shetri, Gumaan S. Rassam, Halima K. Joher, Mashhoor A. Bin Shehab, Mohammed S. Bin Mosalem

AUIQ Complementary Biological System

Qat (Catha edulis) chewing is a common practice in Yemen, associated with oral mucosal irritation. The objective of the current study is to compare cytological findings of buccal mucosa between Qat chewers and non-chewers. A comparative cross-sectional study was designed. Buccal smears were collected from chewers (n = 100) and non-chewers (n = 100), fixed, and stained with Harris hematoxylin staining. Smears were assessed for inflammatory changes and cytological atypia by two blinded examiners; disagreements were resolved by consensus. The inflammatory cells were observed in 21% of chewers compared to 8% of controls (P = 0.009), while …

Protocols For Antioxidant Testing: A Mini Review Of Common Assays And Approaches, Abdulsalam Halboup, Sameer A. Alkubati

AUIQ Complementary Biological System

Antioxidants play a pivotal role in mitigating damage caused by oxidative stress, which is implicated in aging, inflammation, neurodegeneration, and various chronic diseases. With the growing interest in natural and synthetic antioxidants across nutraceutical, pharmaceutical, and food industries, the need for reliable, reproducible, and standardized testing methods has become increasingly urgent. This mini-review provides a structured overview of the most widely used antioxidant testing protocols, categorized into in vitro chemical-based assays (e.g., DPPH, ABTS, FRAP, metal chelation), cell-based assays (e.g., DCFH-DA for intracellular ROS detection), and in vivo biomarker-based models. Each method’s principle, experimental protocol, advantages, and limitations are critically …

Prevalence Of Giardia Infection: A Cross-Sectional Study In Basra Province, Iraq, Sarah Kamal Naser

AUIQ Complementary Biological System

Giardiasis is a common parasite infection that is seen more frequently than any other parasitic infection worldwide. This infection is especially prevalent in tropical areas and in developing nations that have a poor standard of living and poor health conditions. The Giardia parasite is able to infect people of any gender, as it enters the body by the mouth, passes down the oesophagus, and finally reaches the stomach, where it is not negatively impacted by gastric acids. The goal of this study is to determine the extent to which patients who were treated at Al-Zubair General Hospital in Basra, Iraq, …

Mmp-7 Expression And Rs11225307 Polymorphism In Breast Cancer And Fibroadenoma: A Molecular Study In Basrah, Iraq, Heba Jassam, Wijdan Nazar Ibraheim, Mazin Hawwaz Abdulridha, Rafid Adil Abood, Karam B. Nanjem

AUIQ Complementary Biological System

Breast cancer (BC) progression relies heavily on extracellular matrix degradation, mediated in part by matrix metalloproteinase-7 (MMP-7). While overexpression of MMP-7 has been implicated in multiple cancers, data from Middle Eastern populations remain limited.

This study examined MMP-7 gene expression and polymorphism patterns, with emphasis on rs11225307, in breast cancer versus benign fibroadenoma (FA) tissues among women in Basrah, Iraq. Thirty-seven BC and twenty-three FA patients were enrolled. MMP-7 mRNA expression was quantified using qRT-PCR and normalized to β-actin, while polymorphisms were analyzed through Sanger sequencing of eight SNPs and allele-specific PCR for rs11225307. Statistical significance was set at …

Comparison Of Metal Nanoparticles As Antifungal Agents: Efficacy, Mechanisms, And Toxicity Against Candida, Aspergillus, And Cryptococcus, Ahmed Falah Imran, Hayder Hameed Saeed, Khaldoon Jasim Mohammed

AUIQ Complementary Biological System

Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans are the invasive fungi whose diseases are becoming a growing health issue in the global community, particularly in immunocompromised people. The increasing resistance of the conventional antifungals and the shortage of the existing treatment methods require alternative methods. The present review is an evaluation of the antifungal activity of metal-based nanoparticles, including silver (Ag), copper (Cu), zinc oxide (ZnO), titanium dioxide (TiO₂), and selenium (Se) in relation to the three predominant pathogenic fungi. It also talks about their mode of action, relative efficacy, toxicity and their possible future clinical …

Renoprotective Potential Of Ciprofloxacin, Prednisolone, And Infliximab In Acetic Acid-Induced Ulcerative Colitis Rats, O. A. Oyesola, O. E. Olayemi, B. I. Kukoyi

AUIQ Complementary Biological System

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with systemic manifestations, including renal impairment mediated by oxidative stress, inflammation, and electrolyte imbalance. This study investigated the renoprotective potential of ciprofloxacin, prednisolone, and infliximab in rats with acetic acid–induced UC. Fifty male Sprague–Dawley rats (180–200 g) were divided into five groups (n = 10): control, UC control, UC + ciprofloxacin (50 mg/kg, p.o.), UC + prednisolone (4 mg/kg, p.o.), and UC + infliximab (5 mg/kg, i.p.). UC was induced by rectal instillation of 4% acetic acid, and treatments were administered for 42 days. Serum urea, creatinine, electrolytes, and malondialdehyde (MDA) …

Mesenchymal Stem Cells As Cornerstones Of Regenerative Medicine: Mechanisms, Applications, And Future Perspectives, Hasan M. Agha, Mohammed A. Abdalqader, Jantson Hoh, Yacoub Wassouf, Khudhur Abbas Ahmed Al-Saadawi, Amjad Abdulhadi Mohammed, Muneer Mohammed Saleh Alsayadi

AUIQ Complementary Biological System

Regenerative medicine is a multidisciplinary domain focused on restoring, repairing, or replacing damaged tissues and organs by harnessing the body’s inherent healing abilities with sophisticated biological and technical techniques. Mesenchymal stem cells (MSCs) have become fundamental among many stem cell types because to their self-renewal, multipotency, paracrine signaling, and immunomodulatory capabilities. Their therapeutic adaptability has been shown in orthopedic, cardiovascular, neurological, dermatological, and immune-mediated illnesses, underscoring their clinical significance. Nonetheless, obstacles like donor heterogeneity, senescence during in vitro growth, restricted engraftment, and regulatory impediments persist in limiting repeatability and broad clinical use. Recent advancements are enhancing the capabilities of MSCs …