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Pomegranate (Punica Granatum L.) Reduces Endoplasmic Reticulum Stress Induced By Renal Ischemia/Reperfusion Injury In Rat, Khadijeh Hashemi, Kazem Parivar, Samira Fazlifar, Alireza Haghparast, Mehrdad Mohri, Naser Margan Azghadi, Mohammadhossein Nazem Shirazi, Amir Afkhami Goli
Pomegranate (Punica Granatum L.) Reduces Endoplasmic Reticulum Stress Induced By Renal Ischemia/Reperfusion Injury In Rat, Khadijeh Hashemi, Kazem Parivar, Samira Fazlifar, Alireza Haghparast, Mehrdad Mohri, Naser Margan Azghadi, Mohammadhossein Nazem Shirazi, Amir Afkhami Goli
Turkish Journal of Biology
Ischemia/reperfusion (I/R) is one of the main causes of acute renal failure, leading to generation of reactive oxygen species (ROS) and ensuing oxidative stress, which results in unfolded/misfolded protein accumulation and its dependent response pathways, generally known as unfolded protein response (UPR), in the endoplasmic reticulum (ER). We studied the effects of renal I/R on the expression of ER-stress genes, as well as concomitant effects of oral pretreatment with pomegranate (Punica granatum L.) pith and carpellary membrane (PPCM). An in vivo model of rat kidney I/R followed by conventional and real-time RT-PCR was used to evaluate the modulation of GRP78 …
Membrane And Dna Damaging/Protective Effects Of Eugenol, Eucalyptol, Terpinen-4-Ol, And Camphor At Various Concentrations On Parental And Drug-Resistant H1299 Cells, Aysun Özkan, Ayşe Erdoğan
Membrane And Dna Damaging/Protective Effects Of Eugenol, Eucalyptol, Terpinen-4-Ol, And Camphor At Various Concentrations On Parental And Drug-Resistant H1299 Cells, Aysun Özkan, Ayşe Erdoğan
Turkish Journal of Biology
Eugenol, eucalyptol, terpinen-4-ol, and camphor, used as flavor agents in cosmetic and food products, have both prooxidant and antioxidant activities. To clarify the mechanisms of their cytotoxic effect and the factors affecting their antioxidant/prooxidant activities, we investigated cell membrane and DNA damage/protective effects induced by eugenol, eucalyptol, terpinen-4-ol, and camphor in parental and drug-resistant human lung cancer cell lines. The parental cells were found approximately 3, 6, and 8 times more sensitive to camphor cytotoxicity than drug-resistant cells at 24, 48, and 72 h respectively. The cytotoxic activity for both cell types was found to be in the order of …