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Full-Text Articles in Biology
Djungarian Hamsters Exhibit Temperature-Dependent Dietary Fat Choice In Long Days, Sara Hiebert Burch, Kelley Carl Hauser , '99, Abbas Ebrahim , '00
Djungarian Hamsters Exhibit Temperature-Dependent Dietary Fat Choice In Long Days, Sara Hiebert Burch, Kelley Carl Hauser , '99, Abbas Ebrahim , '00
Biology Faculty Works
Previous studies have shown that whole-animal thermal responses of ectotherms and heterotherms (e.g., hibernators), both of which experience a wide range of body temperatures, are related to the saturation level of somatic lipids, which in turn can be influenced by the ratio of saturated and unsaturated fatty acids in the diet. This study demonstrates that Djungarian hamsters held in long days display ambient temperature dependent choice of dietary fats, increasing their preference for saturated fats when ambient temperature increases ( to 27 degreesC) and later reversing this preference when ambient temperature is returned to its original value ( 8 degreesC). …
Regression Approaches For Microarray Data Analysis, Mark R. Segal, Kam D. Dahlquist, Bruce R. Conklin
Regression Approaches For Microarray Data Analysis, Mark R. Segal, Kam D. Dahlquist, Bruce R. Conklin
Biology Faculty Works
A variety of new procedures have been devised to handle the two sample comparison (e.g., tumor versus normal tissue) of gene expression values as measured with microarrays. Such new methods are required in part because of some defining characteristics of microarray-based studies: (i) the very large number of genes contributing expression measures which far exceeds the number of samples (observations) available, and (ii) the fact that by virtue of pathway/network relationships, the gene expression measures tend to be highly correlated. These concerns are exacerbated in the regression setting, where the objective is to relate gene expression, simultaneously for multiple genes, …
Mappfinder: Using Gene Ontology And Genmapp To Create A Global Gene-Expression Profile From Microarray Data, Scott W. Doniger, Nathan Salomonis, Kam D. Dahlquist, Karen Vranizan, Steven C. Lawlor, Bruce R. Conklin
Mappfinder: Using Gene Ontology And Genmapp To Create A Global Gene-Expression Profile From Microarray Data, Scott W. Doniger, Nathan Salomonis, Kam D. Dahlquist, Karen Vranizan, Steven C. Lawlor, Bruce R. Conklin
Biology Faculty Works
MAPPFinder is a tool that creates a global gene-expression profile across all areas of biology by integrating the annotations of the Gene Ontology (GO) Project with the free software package GenMAPP (http://www.GenMAPP.org). The results are displayed in a searchable browser, allowing the user to rapidly identify GO terms with over-represented numbers of geneexpression changes. Clicking on GO terms generates GenMAPP graphical files where gene relationships can be explored, annotated, and files can be freely exchanged.
Educating For Social Responsibility: Changing The Syllabus Of Developmental Biology, Scott F. Gilbert, A. Fausto-Sterling
Educating For Social Responsibility: Changing The Syllabus Of Developmental Biology, Scott F. Gilbert, A. Fausto-Sterling
Biology Faculty Works
Developmental biology is deeply embedded in the social issues of our times. Such topics as cloning, stems cells, reproductive technologies, sex selection, environmental hormone mimics and gene therapy all converge on developmental biology. It is therefore critical that developmental biologists learn about the possible social consequences of their work and of the possible molding of their discipline by social forces. We present two models for integrating social issues into the developmental biology curriculum. One model seeks to place discussions of social issues into the laboratory portion of the curriculum; the other model seeks to restructure the course, such that developmental …
The Reactive Genome, Scott F. Gilbert
The Role Of Predator-Induced Polyphenism In The Evolution Of Cognition: A Baldwinian Speculation, Scott F. Gilbert
The Role Of Predator-Induced Polyphenism In The Evolution Of Cognition: A Baldwinian Speculation, Scott F. Gilbert
Biology Faculty Works
No abstract provided.
Proteasome Inhibition Stabilizes Tau Inclusions In Oligodendroglial Cells That Occur After Treatment With Okadaic Acid, Deepa V. Dabir
Proteasome Inhibition Stabilizes Tau Inclusions In Oligodendroglial Cells That Occur After Treatment With Okadaic Acid, Deepa V. Dabir
Biology Faculty Works
Tau-positive inclusions in oligodendrocytes are consistent neuropathological features of corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementias with Parkinsonism linked to chromosome 17. Here we show by immunohistochemistry that tau-positive oligodendroglial inclusion bodies also contain the small heat-shock protein (HSP) αB-crystallin but not H HSP70. To study the molecular mechanisms underlying inclusion body formation, we engineered an oligodendroglia cell line (OLN-t40) to overexpress the longest human tau isoform. Treatment of OLN-t40 cells with okadaic acid (OA), an inhibitor of protein phosphatase 2A, caused tau hyperphosphorylation and a decrease in the binding of tau to microtubules. Simultaneously, tau-positive aggregates that also …
Web Orientation Of The Banded Garden Spider Argiope Trifasciata (Araneae, Araneidae) In A California Coastal Population, Martina G. Ramirez
Web Orientation Of The Banded Garden Spider Argiope Trifasciata (Araneae, Araneidae) In A California Coastal Population, Martina G. Ramirez
Biology Faculty Works
Magnetic heading (direction the spider’s ventrum faced) and web inclination (degree of slant from the vertical) in Argiope trifasciata Forska°l, a diurnal orb-weaving spider, were studied at a coastal site in southern California for nine weeks in fall 1999. Throughout the study, A. trifasciata largely occupied east-west oriented webs with their venters facing south and southwest. Mean magnetic heading was unaffected by ambient temperature extremes. Inclination levels varied from week to week over an approximately 58 range. However, these changes followed no discernible pattern and were independent both of the sun’s decrease in maximum altitude during the course of the …
Thicker Than Blood: Conserved Mechanisms In Drosophila And Vertebrate Hematopoiesis, Cory J. Evans
Thicker Than Blood: Conserved Mechanisms In Drosophila And Vertebrate Hematopoiesis, Cory J. Evans
Biology Faculty Works
Blood development in Drosophila melanogaster shares several interesting features with hematopoiesis in vertebrates, including spatiotemporal regulation as well as the use of similar transcriptional regulators and signaling pathways. In this review, we describe what is known about hematopoietic development in Drosophila and the various cell types generated and their functions. Additionally, the molecular genetic mechanisms of hematopoietic cell fate determination and commitment within Drosophila blood cell lineages are discussed and compared to vertebrate mechanisms.
Review Of "Embryos In Wax: Models From The Ziegler Studio" By N. Hopwood, Scott F. Gilbert
Review Of "Embryos In Wax: Models From The Ziegler Studio" By N. Hopwood, Scott F. Gilbert
Biology Faculty Works
No abstract provided.
The Morphogenesis Of Evolutionary Developmental Biology, Scott F. Gilbert
The Morphogenesis Of Evolutionary Developmental Biology, Scott F. Gilbert
Biology Faculty Works
The early studies of evolutionary developmental biology (Evo-Devo) come from several sources. Tributaries flowing into Evo-Devo came from such disciplines as embryology, developmental genetics, evolutionary biology, ecology, paleontology, systematics, medical embryology and mathematical modeling. This essay will trace one of the major pathways, that from evolutionary embryology to Evo-Devo and it will show the interactions of this pathway with two other sources of Evo-Devo: ecological developmental biology and medical developmental biology. Together, these three fields are forming a more inclusive evolutionary developmental biology that is revitalizing and providing answers to old and important questions involving the formation of biodiversity on …