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Articles 1 - 30 of 35
Full-Text Articles in Biology
Overview Of The Zoonotic Potential And Coinfection Of Sars-Cov-2 In Indonesia, Muhammad Khaliim Jati Kusala, Ni Luh Putu Indi Dharmayanti
Overview Of The Zoonotic Potential And Coinfection Of Sars-Cov-2 In Indonesia, Muhammad Khaliim Jati Kusala, Ni Luh Putu Indi Dharmayanti
Karbala International Journal of Modern Science
In the ASEAN region, Indonesia has the highest overall COVID-19 infection score. The SARS-CoV-2 pandemic first emerged in China and then transmitted sporadically throughout the world. Animals and humans can be infected with the corona virus, so this disease is classified as a zoonotic disease. This review aims to gather information regarding the potential of SARS-CoV-2 as a zoonotic disease and coinfections with several other pathogens in Indonesia. This study collected data demonstrating the potential for COVID-19 to be transmitted from humans to animals, as an evidenced by positive test results for the Bat Coronavirus Antigen in bats. Cats have …
An Investigation Of Mitigation Measures On The Spread Of Covid-19 In A College Classroom Using Agent-Based Modeling, Saharsh Talwar, Anne E. Yust
An Investigation Of Mitigation Measures On The Spread Of Covid-19 In A College Classroom Using Agent-Based Modeling, Saharsh Talwar, Anne E. Yust
Spora: A Journal of Biomathematics
In this manuscript, we describe the process of using agent-based modeling in NetLogo to create a simulation of COVID-19 spread in a traditional college classroom. The model allows for an evaluation of different preventative measures implemented by the University of Pittsburgh, including the cohort classroom attendance model, mask and vaccine mandates, contact tracing, and classroom sanitation. Through the use of the model's interactive interface, the impact of adjusting specific measures by the institution could be visualized, providing a valuable tool for combating diseases that spread through droplet transmission.
(R1954) Fractional Order On Modeling The Transmission Of Devastative Covid-19 Infection: Efficacy Of Vaccination, Ashutosh Rajput, Tanvi ., Rajiv Aggarwal, Arpana Sharma, Shiv Kumar Sahdev, Manoj Kumar, Jaimala .
(R1954) Fractional Order On Modeling The Transmission Of Devastative Covid-19 Infection: Efficacy Of Vaccination, Ashutosh Rajput, Tanvi ., Rajiv Aggarwal, Arpana Sharma, Shiv Kumar Sahdev, Manoj Kumar, Jaimala .
Applications and Applied Mathematics: An International Journal (AAM)
The second wave of COVID-19 is an unprecedented condition in India and began in mid February 2021. Individuals who were already suffering from other comorbidities were found with lung infection, and hence, the number of disease induced deaths were rising faster during the second wave in relation to the first wave. This paper has proposed a mathematical model with fractional order derivatives by correlating the model based number of infectives with the real number of infectives in India. For the system of fractional differential equations, a disease-free state has been computed and proved to be locally asymptotically stable with certain …
Candida Spp. Associated With Covid-19 And Its Susceptibility To Some Antifungals, Mohammed Mudhafar Alkhuzaie, Neeran Obied Jasim
Candida Spp. Associated With Covid-19 And Its Susceptibility To Some Antifungals, Mohammed Mudhafar Alkhuzaie, Neeran Obied Jasim
Al-Qadisiyah Journal of Pure Science
The aim of this study was to conduct a survey of the Candida species associated with COVID-19 viral infection in 150 patients who were admitted to the intensive care unit (ICU) in Al-Diwaniyah Teaching Hospital in Al-Diwaniyah City, Iraq, for a five-month period from October 2021 to February 2022. The results indicated the dominance of Candida spp. over the rest of the isolated fungal species, with 97 isolates (64.66%). C. albicans was shown to be the most abundant species with a percentage of 55.67 percent (P 0.05), compared to the other Candida species that were isolated (Candida tropicalis 13.4 percent, …
Candida Spp. Associated With Covid-19 And Its Susceptibility To Some Antifungals, Mohammed Mudhafar Alkhuzaie, Neeran Obied Jasim
Candida Spp. Associated With Covid-19 And Its Susceptibility To Some Antifungals, Mohammed Mudhafar Alkhuzaie, Neeran Obied Jasim
Al-Qadisiyah Journal of Pure Science
The aim of this study was to conduct a survey of the Candida speciesassociated with COVID-19 viral infection in 150 patients who were admitted to the intensive care unit (ICU) in Al-Diwaniyah Teaching Hospital in Al-Diwaniyah City, Iraq, for a five-month period from October 2021 to February 2022. The results indicated the dominance of Candida spp.over the rest of the isolated fungal species, with 97 isolates (64.66%). C. albicans was shown to be the most abundant species with a percentage of 55.67 percent (P 0.05), compared to the other Candida speciesthat were isolated (Candida tropicalis13.4 percent, Candida glabrata12 percent, Candida …
Glcms Based Multi-Inputs 1d Cnn Deep Learning Neural Network For Covid-19 Texture Feature Extraction And Classification, Elaf Ali Abbood, Tawfiq A. Al-Assadi
Glcms Based Multi-Inputs 1d Cnn Deep Learning Neural Network For Covid-19 Texture Feature Extraction And Classification, Elaf Ali Abbood, Tawfiq A. Al-Assadi
Karbala International Journal of Modern Science
Coronavirus disease 2019 epidemic (COVID-19) is an infectious disease that appeared because of the newest version of discovered coronavirus. The advent and rapid spread of this disease over the world necessitated a concerted effort to contain and eradicate it. Computer Tomography (CT) imaging and X-Ray images are considered as one of the important medical examinations used for disease diagnosis. To speed up and confirm the correctness of the medical diagnosis, many artificial intelligence techniques and machine learning methods are proposed. In this paper, a new and efficient proposed system is introduced to extract appropriate and meaningful features for CT scans …
Adoptive T-Cell Therapies To Overcome T Cell-Dependent Immune Dysregulations In Covid-19, Sevgi̇ Kalkanli Taş, Merve Sai̇de Uzunoğlu, Ayli̇n Seher Uzunoğlu, Duygu Kirkik, Derya Altunkanat, Nevi̇n Kalkanli
Adoptive T-Cell Therapies To Overcome T Cell-Dependent Immune Dysregulations In Covid-19, Sevgi̇ Kalkanli Taş, Merve Sai̇de Uzunoğlu, Ayli̇n Seher Uzunoğlu, Duygu Kirkik, Derya Altunkanat, Nevi̇n Kalkanli
Turkish Journal of Biology
Coronavirus disease 2019 (COVID-19) pandemic has been an important global interest that affected millions of people, and it requires a deep investigation of the disease immunology for developing further therapeutic applications. Adoptive T cell therapy promises to address T cell-dependent immune dysregulation in COVID-19 patients by the generation of specific T cell clones against virus-specific antigens. Additionally, targeting B cell-dependent protection through COVID-19 vaccines, which have been developed in the recent year, possessed sufficient prevention for spreading the virus, since the cases and deaths related to COVID-19 tend to decrease after the vaccination. However, adoptive cell therapies are now encouraging …
Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan
Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan
Turkish Journal of Biology
Human SARS coronavirus 2 (SARS-CoV-2) causes the current global COVID-19 pandemic. The production of an efficient vaccine against COVID-19 is under heavy investigation. In this study, we have designed a novel multiepitope DNA vaccine against SARS-CoV-2 using reverse vaccinology and DNA vaccine approaches. Applying these strategies led to reduce the time and costs of vaccine development and also improve the immune protective characteristics of the vaccine. For this purpose, epitopes of nucleocapsid, membrane glycoprotein, and ORF8 proteins of SARS-CoV-2 chose as targets for B and T-cell receptors. Accordingly, DNA sequences of selected epitopes have optimized for protein expression in the …
(R1468) Global Analysis Of An Seirs Model For Covid-19 Capturing Saturated Incidence With Treatment Response, David A. Oluyori, Helen O. Adebayo, Ángel G.C. Pérez
(R1468) Global Analysis Of An Seirs Model For Covid-19 Capturing Saturated Incidence With Treatment Response, David A. Oluyori, Helen O. Adebayo, Ángel G.C. Pérez
Applications and Applied Mathematics: An International Journal (AAM)
In this work, a new SEIRS model with saturated incidence rate and piecewise linear treatment response is proposed to describe the dynamics of COVID-19. It is assumed that the treatment response is proportional to the number of infected people as long as the incidence cases are within the capacity of the healthcare system, after which the value becomes constant, when the number of confirmed cases exceeds the carrying capacity of the available medical facilities. Thus, the basic reproduction number of the model is obtained. It is proved that the disease-free equilibrium is globally asymptotically stable when the basic reproduction number …
A Comparison Of The Evolution, Structure, And Function Of Sars-Cov And Sars-Cov-2 Spike Proteins, Tai Michaels
A Comparison Of The Evolution, Structure, And Function Of Sars-Cov And Sars-Cov-2 Spike Proteins, Tai Michaels
The Yale Undergraduate Research Journal
As the COVID-19 pandemic has developed into the largest pandemic of the twenty-first century, it has become apparent that this disease, caused by the SARS-CoV-2 virus, is unlike anything the modern world has faced before. Not only has the disease infected more than 16 million people worldwide, but its rapid spread has drawn global attention to the gaps in our understanding of its pathogenesis and the development of vaccines and treatments. One of the most important topics of research in the disease is the viral spike (S) protein which facilitates binding and entering host cells and plays a key role …
Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 1, Issue 1, June 2021
Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 1, Issue 1, June 2021
International Undergraduate Journal of Health Sciences
The full June 2021 issue (Volume 1, Issue 1) of the International Undergraduate Journal of Health Sciences
The Effect Of Weekend Curfews On Epidemics: A Monte Carlo Simulation, Hakan Kaygusuz, Ahmet Ni̇hat Berker
The Effect Of Weekend Curfews On Epidemics: A Monte Carlo Simulation, Hakan Kaygusuz, Ahmet Ni̇hat Berker
Turkish Journal of Biology
The ongoing COVID-19 pandemic is being responded with various methods, applying vaccines, experimental treatment options, total lockdowns or partial curfews. Weekend curfews are among the methods for reducing the number of infected persons, and this method is practically applied in some countries such as Turkey. In this study, the effect of weekend curfews on reducing the spread of a contagious disease, such as COVID-19, is modeled using a Monte Carlo algorithm with a hybrid lattice model. In the simulation setup, a fictional country with three towns and 26,610 citizens were used as a model. Results indicate that applying a weekend …
In Silico Drug Repositioning Against Human Nrp1 To Block Sars-Cov-2 Host Entry, Şeref Gül
In Silico Drug Repositioning Against Human Nrp1 To Block Sars-Cov-2 Host Entry, Şeref Gül
Turkish Journal of Biology
Despite COVID-19 turned into a pandemic, no approved drug for the treatment or globally available vaccine is out yet. In such a global emergency, drug repurposing approach that bypasses a costly and long-time demanding drug discovery process is an effective way in search of finding drugs for the COVID-19 treatment. Recent studies showed that SARS-CoV-2 uses neuropilin-1 (NRP1) for host entry. Here we took advantage of structural information of the NRP1 in complex with C-terminal of spike (S) protein of SARSCoV- 2 to identify drugs that may inhibit NRP1 and S protein interaction. U.S. Food and Drug Administration (FDA) approved …
Cannabinoids For Sars-Cov-2 And Is There Evidence Of Their Therapeutic Efficacy?, Ahmet Onay, Abdulselam Ertaş, Veysel Süzerer, İsmai̇l Yener, Mustafa Abdullah Yilmaz, Emi̇ne Ayaz Ti̇lkat, Remzi̇ Eki̇nci̇, Nesri̇n Bozhan, Sevgi̇ İrtegün
Cannabinoids For Sars-Cov-2 And Is There Evidence Of Their Therapeutic Efficacy?, Ahmet Onay, Abdulselam Ertaş, Veysel Süzerer, İsmai̇l Yener, Mustafa Abdullah Yilmaz, Emi̇ne Ayaz Ti̇lkat, Remzi̇ Eki̇nci̇, Nesri̇n Bozhan, Sevgi̇ İrtegün
Turkish Journal of Biology
To combat the coronaviruses and their novel variants, therapeutic drugs and the development of vaccines that are to be effective throughout human life are urgently needed. The endocannabinoid system (ECS) acts as a modulator in the activation of the microcirculation, immune system, and autonomic nervous system, along with controlling pharmacological functions such as emotional responses, homeostasis, motor functions, cognition, and motivation. The ECS contains endogenous cannabinoids, cannabinoid receptor (CBRs), and enzymes that regulate their biosynthesis, transport, and degradation. Moreover, phytocannabinoids and synthetic cannabinoids that mimic the action of endocannabinoids also play an essential role in the modulation of the ECS. …
Novel Approaches For Covid-19 Diagnosis And Treatment: A Nonsystematic Review, Şebnem Gari̇p Ustaoğlu, Hakan Kaygusuz, Mehmet Di̇nçer Bi̇lgi̇n, Feri̇de Severcan
Novel Approaches For Covid-19 Diagnosis And Treatment: A Nonsystematic Review, Şebnem Gari̇p Ustaoğlu, Hakan Kaygusuz, Mehmet Di̇nçer Bi̇lgi̇n, Feri̇de Severcan
Turkish Journal of Biology
Since COVID-19 pandemic has been continuously rising and spreading, several original contributions and review articles on COVID-19 started to appear in the literature. The review articles are mainly focus on the current status of the pandemic along with current status of the corona diagnosis and treatment process. Due to some disadvantages of the currently used methods, the improvement on the novel promising diagnosis and treatment methods of corona virus is very important issue. In this review, after briefly discussing the status of current diagnosis and treatment methods, we present to the scientific community, novel promising methods in the diagnosis and …
Neuropathy In Covid-19 Associated With Dysbiosis-Related Inflammation, Busra Aktas, Belma Aslim
Neuropathy In Covid-19 Associated With Dysbiosis-Related Inflammation, Busra Aktas, Belma Aslim
Turkish Journal of Biology
Although COVID-19 affects mainly lungs with a hyperactive and imbalanced immune response, gastrointestinal and neurological symptoms such as diarrhea and neuropathic pains have been described as well in patients with COVID-19. Studies indicate that gut-lung axis maintains host homeostasis and disease development with the association of immune system, and gut microbiota is involved in the COVID-19 severity in patients with extrapulmonary conditions. Gut microbiota dysbiosis impairs the gut permeability resulting in translocation of gut microbes and their metabolites into the circulatory system and induce systemic inflammation which, in turn, can affect distal organs such as the brain. Moreover, gut microbiota …
Genomic Chronicle Of Sars-Cov-2: A Mutational Analysis With Over 1 Million Genome Sequences, Osman Mutluhan Uğurel, Oğuz Ata, Di̇lek Balik
Genomic Chronicle Of Sars-Cov-2: A Mutational Analysis With Over 1 Million Genome Sequences, Osman Mutluhan Uğurel, Oğuz Ata, Di̇lek Balik
Turkish Journal of Biology
Use of information technologies to analyse big data on SARS-CoV-2 genome provides an insight for tracking variations and examining the evolution of the virus. Nevertheless, storing, processing, alignment and analyses of these numerous genomes are still a challenge. In this study, over 1 million SARS-CoV-2 genomes have been analysed to show distribution and relationship of variations that could enlighten development and evolution of the virus. In all genomes analysed in this study, a total of over 215M SNVs have been detected and average number of SNV per isolate was found to be 21.83. Single nucleotide variant (SNV) average is observed …
The Current State Of Validated Small Molecules Inhibiting Sars-Cov-2 Non-Structural Proteins, Fati̇h Kocabaş, Merve Uslu
The Current State Of Validated Small Molecules Inhibiting Sars-Cov-2 Non-Structural Proteins, Fati̇h Kocabaş, Merve Uslu
Turkish Journal of Biology
The current COVID-19 outbreak has had a profound influence on public health and daily life. Despite all restrictions and vaccination programs, COVID-19 still can lead to fatality due to a lack of COVID-19-specific treatments. A number of studies have demonstrated the feasibility to develop therapeutics by targeting underlying components of the viral proteome. Here we reviewed recently developed and validated small molecule inhibitors of SARS-CoV-2's nonstructural proteins. We described the validation level of identified compounds specific for SARS-CoV-2 in the presence of in vitro and in vivo supporting data. The mechanisms of pharmacological activity, as well as approaches for developing …
Treatment Of Covid-19 Patients With Quercetin In Combination With Vitamin C And Bromelain: A Prospective, Single - Centre, Randomized, Controlled Trial, Hasan Önal, Bengü Arslan, Nurcan Üçüncü Ergun, Hani̇m Şeyma Topuz, Seda Yilmaz Semerci̇, Mehmet Eren Kurnaz, Yulet Mi̇ray Molu, Mehmet Abdussamet Bozkurt, Nuretti̇n Süner, Ali̇ Kocataş
Treatment Of Covid-19 Patients With Quercetin In Combination With Vitamin C And Bromelain: A Prospective, Single - Centre, Randomized, Controlled Trial, Hasan Önal, Bengü Arslan, Nurcan Üçüncü Ergun, Hani̇m Şeyma Topuz, Seda Yilmaz Semerci̇, Mehmet Eren Kurnaz, Yulet Mi̇ray Molu, Mehmet Abdussamet Bozkurt, Nuretti̇n Süner, Ali̇ Kocataş
Turkish Journal of Biology
Scientific research continues on new preventive and therapeutic strategies against severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2). So far, there is no proven curative treatment, and a valid alternative therapeutic approach needs to be developed. This study is designed to evaluate the effect of quercetin in COVID-19 treatment. This was a single-centre, prospective randomized controlled cohort study. Routine care versus QCB (quercetin, vitamin C, bromelain) supplementation was compared between 429 patients with at least one chronic disease and moderate-to-severe respiratory symptoms. Demographic features, signs, laboratory results and drug administration data of patients were recorded. The endpoint was that QCB supplementation was …
Current Mutatome Of Sars-Cov-2 In Turkey Reveals Mutations Of Interest, Doğa Eski̇er, Evren Akalp, Özlem Dalan, Gökhan Karakülah, Yavuz Oktay
Current Mutatome Of Sars-Cov-2 In Turkey Reveals Mutations Of Interest, Doğa Eski̇er, Evren Akalp, Özlem Dalan, Gökhan Karakülah, Yavuz Oktay
Turkish Journal of Biology
As the underlying pathogen for the COVID-19 pandemic that has affected tens of millions of lives worldwide, SARS-CoV-2 and its mutations are among the most urgent research topics worldwide. Mutations in the virus genome can complicate attempts at accurate testing or developing a working treatment for the disease. Furthermore, because the virus uses its own proteins to replicate its genome, rather than host proteins, mutations in the replication proteins can have cascading effects on the mutation load of the virus genome. Due to the global, rapidly developing nature of the COVID-19 pandemic, local demographics of the virus can be difficult …
An Update Comprehensive Review On The Status Of Covid-19: Vaccines, Drugs, Variants And Neurological Symptoms, Ebru Özkan Oktay, Sali̇h Tuncay, Tuğba Kaman, Ömer Faruk Karasakal, Öznur Özge Özcan, Tuğçe Soylamiş, Mesut Karahan, Muhsi̇n Konuk
An Update Comprehensive Review On The Status Of Covid-19: Vaccines, Drugs, Variants And Neurological Symptoms, Ebru Özkan Oktay, Sali̇h Tuncay, Tuğba Kaman, Ömer Faruk Karasakal, Öznur Özge Özcan, Tuğçe Soylamiş, Mesut Karahan, Muhsi̇n Konuk
Turkish Journal of Biology
Various recently reported mutant variants, candidate and urgently approved current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many current situations with severe neurological damage and symptoms as well as respiratory tract disorders have begun to be reported. In particular, drug, vaccine, and neutralizing monoclonal antibodies (mAbs) have been developed and are currently being evaluated in clinical trials. Here, we review lessons learned from the use of novel mutant variants of the COVID-19 virus, immunization, new drug solutions, and antibody therapies for infections. Next, we focus on the B 1.1.7, B 1.351, P.1, and B.1.617 lineages or variants of …
Pathogenesis And Treatment Of Cytokine Storm In Covid-19, Mehmet Soy, Gökhan Keser, Mehmet Pami̇r Atagündüz
Pathogenesis And Treatment Of Cytokine Storm In Covid-19, Mehmet Soy, Gökhan Keser, Mehmet Pami̇r Atagündüz
Turkish Journal of Biology
COVID-19 is a viral infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that killed a large number of patients around the world. A hyperinflammatory state resulting in a cytokine storm and adult respiratory distress syndrome seems to be the major cause of the death. Many mechanisms have been suggested in the pathogenesis of COVID-19 associated cytokine storm (COVID-CS). Insufficient viral clearance and persistence of a strong cytokine response despite inadequate antiviral immunity seem to be the main mechanisms underlying the pathogenesis. The diagnosis of COVID-19 is based on relatively constant clinical symptoms, clinical findings, laboratory tests, and …
Coronavac (Sinovac) Covid-19 Vaccine-Induced Molecular Changes In Healthy Human Serum By Infrared Spectroscopy Coupled With Chemometrics, Ayça Doğan Mollaoğlu, Rafi̇g Gurbanov, Mete Severcan, Feri̇de Severcan
Coronavac (Sinovac) Covid-19 Vaccine-Induced Molecular Changes In Healthy Human Serum By Infrared Spectroscopy Coupled With Chemometrics, Ayça Doğan Mollaoğlu, Rafi̇g Gurbanov, Mete Severcan, Feri̇de Severcan
Turkish Journal of Biology
From the beginning of the COVID-19 coronavirus pandemic in December of 2019, the disease has infected millions of people worldwide and caused hundreds of thousands of deaths. Since then, several vaccines have been developed. One of those vaccines is inactivated CoronaVac-Sinovac COVID-19 vaccine. In this proof of concept study, we first aimed to determine CoronaVac-induced biomolecular changes in healthy human serum using infrared spectroscopy. Our second aim was to see whether the vaccinated group can be separated or not from the non-vaccinated group by applying chemometric techniques to spectral data. The results revealed that the vaccine administration induced significant changes …
Estimation Of Transmission Dynamics Of Covid-19 In India: The Influential Saturated Incidence Rate, - Tanvi, Rajiv Aggarwal, Ashutosh Rajput
Estimation Of Transmission Dynamics Of Covid-19 In India: The Influential Saturated Incidence Rate, - Tanvi, Rajiv Aggarwal, Ashutosh Rajput
Applications and Applied Mathematics: An International Journal (AAM)
A non-linear SEIR mathematical model for coronavirus disease in India has been proposed, by incorporating the saturated incidence rate on the occurrence of new infections. In the model, the threshold quantity known as the reproduction number is evaluated which determines the stability of disease-free equilibrium and the endemic equilibrium points. The disease-free equilibrium point becomes globally asymptotically stable when the corresponding reproduction number is less than unity, whereas, if it is greater than unity then the endemic equilibrium point comes into existence, which is locally asymptotically stable under certain restrictions on the parameters value in the model. The impact of …
Advancements In Vaccine Development: Measles Vs. Covid-19, Sarah Ziegler
Advancements In Vaccine Development: Measles Vs. Covid-19, Sarah Ziegler
The Science Journal of the Lander College of Arts and Sciences
As an ever-progressing field of study, vaccine development has made headway over the past decades. By doing a comparative study between development of the measles vaccine in the mid-20th century, and the ongoing development of the COVID-19 vaccine in 2020, many of the insights and advancements in the field can be easily highlighted. First, the knowledge and experience gained over those decades has helped the vaccine developing process become more efficient. With more vaccines in production, or at least under study, it is more likely to have a related precedent to build upon, as opposed to relying on a successful …
Biosafety And Biosecurity Approaches To Restrain/Contain And Counter Sars-Cov-2/Covid-19 Pandemic: A Rapid-Review, Tauseef Ahmad, Haroon Haroon, Kuldeep Dhama, Khan Sharun, Fazal Mehmood Khan, Irfan Ahmed, Ruchi Tiwari, Taha Hussein Musa, Muhammad Khan, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales, Jin Hui
Biosafety And Biosecurity Approaches To Restrain/Contain And Counter Sars-Cov-2/Covid-19 Pandemic: A Rapid-Review, Tauseef Ahmad, Haroon Haroon, Kuldeep Dhama, Khan Sharun, Fazal Mehmood Khan, Irfan Ahmed, Ruchi Tiwari, Taha Hussein Musa, Muhammad Khan, D. Katterine Bonilla-Aldana, Alfonso J. Rodriguez-Morales, Jin Hui
Turkish Journal of Biology
Emergence and reemergence of infectious diseases pose significant public health risks that are continuously haunting human civilization in the past several decades. Such emerging pathogens should be considered as a high threat to humans, animals, and environmental health. The year 2020 was welcomed by another significant virus from family Coronaviridae called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease 2019 (COVID-19). The disease was first reported in the city of Wuhan, Hubei province, China. Within a short time, this disease attained the status of the Public Health Emergency of International Concern. Presently, COVID-19 has spread to …
Phylogenetic Analysis Of Sars-Cov-2 Genomes In Turkey, Ogün Adebali̇, Ayli̇n Bi̇rcan, Defne Çi̇rci̇, Burak İşlek, Zeynep Kilinç, Berkay Selçuk, Berk Turhan
Phylogenetic Analysis Of Sars-Cov-2 Genomes In Turkey, Ogün Adebali̇, Ayli̇n Bi̇rcan, Defne Çi̇rci̇, Burak İşlek, Zeynep Kilinç, Berkay Selçuk, Berk Turhan
Turkish Journal of Biology
COVID-19 has effectively spread worldwide. As of May 2020, Turkey is among the top ten countries with the most cases. A comprehensive genomic characterization of the virus isolates in Turkey is yet to be carried out. Here, we built a phylogenetic tree with globally obtained 15,277 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes. We identified the subtypes based on the phylogenetic clustering in comparison with the previously annotated classifications. We performed a phylogenetic analysis of the first 30 SARS-CoV-2 genomes isolated and sequenced in Turkey. We suggest that the first introduction of the virus to the country is earlier …
An Updated Analysis Of Variations In Sars-Cov-2 Genome, Osman Mutluhan Uğurel, Oğuz Ata, Di̇lek Balik
An Updated Analysis Of Variations In Sars-Cov-2 Genome, Osman Mutluhan Uğurel, Oğuz Ata, Di̇lek Balik
Turkish Journal of Biology
A novel pathogen, named SARS-CoV-2, has caused an unprecedented worldwide pandemic in the first half of 2020. As the SARS-CoV-2 genome sequences have become available, one of the important focus of scientists has become tracking variations in the viral genome. In this study, 30366 SARS-CoV-2 isolate genomes were aligned using the software developed by our group (ODOTool) and 11 variations in SARS-CoV-2 genome over 10% of whole isolates were discussed. Results indicated that, frequency rates of these 11 variations change between 3.56%-88.44 % and these rates differ greatly depending on the continents they have been reported. Despite some variations being …
Identification Of The Nucleotide Substitutions In 62 Sars-Cov-2 Sequences From Turkey, Ayşe Banu Demi̇r, Domenico Benvenuto, Yusuf Hakan Abacioğlu, Silvia Angeletti, Massimo Ciccozzi
Identification Of The Nucleotide Substitutions In 62 Sars-Cov-2 Sequences From Turkey, Ayşe Banu Demi̇r, Domenico Benvenuto, Yusuf Hakan Abacioğlu, Silvia Angeletti, Massimo Ciccozzi
Turkish Journal of Biology
A previously unknown coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause coronavirus disease 2019 (COVID-19) pandemic. The first case of COVID-19 in Turkey has been declared in March 11th, 2020 and from there on, more than 150,000 people in the country have been diagnosed with the disease. In this study, 62 viral sequences from Turkey, which have been uploaded to GISAID database, were analyzed by means of their nucleotide substitutions in comparison to the reference SARS-CoV-2 genome from Wuhan. Our results indicate that the viral isolates from Turkey harbor some common mutations with the viral …
An Insight Into The Epitope-Based Peptide Vaccine Design Strategy And Studies Against Covid-19, Murat Topuzoğullari, Tayfun Acar, Peli̇n Peli̇t Arayici, Burcu Uçar, Erennur Uğurel, Emrah Şefi̇k Abamor, Tüli̇n Arasoğlu, Di̇lek Balik, Serap Derman
An Insight Into The Epitope-Based Peptide Vaccine Design Strategy And Studies Against Covid-19, Murat Topuzoğullari, Tayfun Acar, Peli̇n Peli̇t Arayici, Burcu Uçar, Erennur Uğurel, Emrah Şefi̇k Abamor, Tüli̇n Arasoğlu, Di̇lek Balik, Serap Derman
Turkish Journal of Biology
SARS-CoV-2 is a new member of the coronavirus family and caused the pandemic of coronavirus disease 2019 (COVID-19) in 2020. It is crucial to design and produce an effective vaccine for the prevention of rapid transmission and possible deaths wcaused by the disease. Although intensive work and research are being carried out all over the world to develop a vaccine, an effective and approved formulation that can prevent the infection and limit the outbreak has not been announced yet. Among all types of vaccines, epitope-based peptide vaccines outshine with their low-cost production, easy modification in the structure, and safety. In …