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Full-Text Articles in Biology
The Role Of Orphan Nuclear Receptor Dax-1 (Nr0b1) In Human Breast Cancer Cells: Expression, Proliferation And Metastasis, Erin Dishington
The Role Of Orphan Nuclear Receptor Dax-1 (Nr0b1) In Human Breast Cancer Cells: Expression, Proliferation And Metastasis, Erin Dishington
Master's Theses
The orphan nuclear hormone receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita on the X Chromosome, gene 1) plays an important role in the development of adrenal and gonadal tissues and functions as a global negative-regulator of steroidogenesis. In addition, it is known to be involved in several diseases including some cancers. Herein, we describe our examination of the role of DAX-1 in breast cancer, specifically its influence on proliferation and metastasis and its expression during progressive stages of disease. In an effort to understand how DAX-1 influences breast cancer cell proliferation and metastasis, we used MCF7 breast cancer …
Examining The Role Of Dax-1 In Regulation Of Cell Proliferation In Human Breast Cells, Amy E. Scandurra
Examining The Role Of Dax-1 In Regulation Of Cell Proliferation In Human Breast Cells, Amy E. Scandurra
Master's Theses
DAX-1 is a member of the Nuclear Hormone Receptor superfamily and acts as a transcriptional repressor. DAX-1 plays an important role in the development of adrenal and gonadal tissues. In addition to its role in normal cell development and differentiation, DAX-1 appears to have some influence on the progression of cancer. This work aims to examine the role of DAX-1 in regulation of proliferation in breast cancer. In our study, we have expressed DAX-1 in a DAX-1 deficient breast cancer cell line as well as knocked down DAX-1 expression in normal DAX-1 positive breast cells. Through these experiments, we were …