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Articles 1 - 11 of 11
Full-Text Articles in Biology
Examination Of Methylation Status And Occupancy Of Dna Methylation Modifying Proteins On Regulatory Regions Of The Dax-1 Gene, Caroline P. Riedstra
Examination Of Methylation Status And Occupancy Of Dna Methylation Modifying Proteins On Regulatory Regions Of The Dax-1 Gene, Caroline P. Riedstra
Master's Theses
Epigenetic modifications influence gene expression and thereby play a pivotal role in development and disease. Misregulation and mutations in the DAX-1 gene, or Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X chromosome, gene 1, have been implicated in Adrenal Hypoplasia Congenita (AHC) and Dosage Sensitive Sex Reversal (DSS). The orphan nuclear hormone receptor DAX-1 is expressed predominantly in tissues such as the testes, ovaries, breast, adrenal cortex, and lung. Critically, DAX-1 may serve as an indicator of aberrant growth in these tissues. Here we hypothesize that DAX-1 is epigenetically regulated, specifically in cancer cells, thereby reducing its …
Spatial And Seasonal Patterns Of Above- And Belowground Vegetation Biomass And Potential Drivers In The Pascagoula River Delta, Ms, Evan Grimes
Master's Theses
Coastal wetlands provide a valuable wealth of services to the greater coastal ecosystem and human communities. However, threats such as sea level rise and conservation projects, such as freshwater diversions, have the potential to alter coastal wetlands in different ways. In this thesis, I describe the effects of inundation and nitrogen on vegetation productivity using a field-sampling approach and an in situ controlled mesocosm experiment, called a marsh organ. The West Channel of the Pascagoula River contained significantly higher belowground biomass than the East Channel, which is more anthropogenically modified. Vertical distribution of belowground biomass did not strongly vary between …
The Role Of Med12 In Adipogenesis, Caroline Helen Rinderle
The Role Of Med12 In Adipogenesis, Caroline Helen Rinderle
Master's Theses
In order for any function to occur within a cell, transcription factors must be able to interact with genes. When this occurs, genes are expressed, and ultimately, proteins are translated and perform the specific function that needs to be done within the cell. In order for this to occur, genes must interact with transcription machinery. The Mediator complex recruits transcription factors to genes in order to promote cell-type specific gene expression. The Mediator complex is a multi-protein complex consisting of four modules: head, middle, tail, and kinase. The kinase module is known to dissociate from the rest of the complex …
The Role Of Med31 And Med12 In Directing Adipogenesis Of Human Adult-Derived Mesenchymal Stem Cells, Joseph Straub
The Role Of Med31 And Med12 In Directing Adipogenesis Of Human Adult-Derived Mesenchymal Stem Cells, Joseph Straub
Master's Theses
Selective gene expression is crucial in maintaining the self-renewing and multipotent properties of stem cells. Mediator is a large, evolutionarily conserved, multisubunit protein complex that modulates gene expression by relaying signals from cell type-specific transcription factors to RNA polymerase II. In humans, this complex consists of 30 subunits arranged in four modules: head, middle, tail, and kinase. In our introduction, we show the state of the field of Mediator study with a focus on the critical kinase module. In the following chapters, we used siRNA knockdowns to investigate the roles of the highly-conserved core subunit MED31 and the kinase module …
Notch And Mediator Work Together To Direct Hasc Self-Renewal, Jaylen Mumphrey
Notch And Mediator Work Together To Direct Hasc Self-Renewal, Jaylen Mumphrey
Master's Theses
Stem cells are unique in that they possess totipotent, pluripotent, or multipotent differentiation capabilities and can also self-renew. Stem cells are in either a state of selfrenewal or differentiation, but never both. If we are able to gain a full understanding of the underlying mechanisms that allow stem cells to remain self-renewing and multipotent, we will better be able to control the fate of cells, ultimately allowing stem cells to be used to their full capabilities in regenerative medicine. My research focuses on MED12 and its effects on Notch signaling. Here we describe the expression profile and activity of MED12, …
The Role Of Med12 In Adipogenesis Of Human Adipose Stem Cells, Onyekachi Chinelo Idigo
The Role Of Med12 In Adipogenesis Of Human Adipose Stem Cells, Onyekachi Chinelo Idigo
Master's Theses
The interest in adipogenesis stems from the high rate of obesity in the world and the motivation to better understand the process of cell fate in relation to human diseases. Mutations in MED12 lead to developmental disorders and certain malignancies. To date, specific roles of Mediator and MED12 in cell state regulation are unclear, nevertheless, they are critical for understanding stem cell regulation and enhancement of their clinical applications. This study investigates the role of MED12 in relation to the Mediator complex kinase domain to better understand transcriptional control of adipogenesis in hASCs. In this study, MED12 expression was diminished …
A Role For Notch Signaling In Drosophila Spermatogenesis, Adrianna Soriano
A Role For Notch Signaling In Drosophila Spermatogenesis, Adrianna Soriano
Master's Theses
The Notch signaling pathway has diverse functions in male and female gonad development. In Drosophila male embryos, Notch specifies hub cell fate in somatic gonadal precursor cells (SGPs), which are important for maintaining germline stem cells and somatic cyst stem cells throughout the lifetime of adult flies. However, a role for Notch signaling in adult males has only started to emerge recently. Nonetheless, we still don’t understand how the Notch pathway functions to regulate spermatogenesis. Notch has been established to be important for the fertility of multiple systems, including mammals, and must be properly regulated for proper spermatogenesis, but the …
The Evolutionary And Morphological Diversification Of The Subtribe Papionina, Sophie B. Labelle
The Evolutionary And Morphological Diversification Of The Subtribe Papionina, Sophie B. Labelle
Master's Theses
Analysis of variation is critical in understanding evolutionary processes. The subtribe Papionina, defined commonly as baboons and their closest relatives, is a highly morphologically diverse group of primates that is useful for the examination of the relationship between variation and evolution. The subtribe is also a valuable behavioral, ecological, and morphological analogy for hominins. This study uses landmark-based cranial geometric morphometric data and multivariate analysis to test whether the pattern of morphological diversification present in Papionina is consistent with genetic drift and/or selection. The study sample consists of six extant genera of Papionin, represented by ~500 individuals collected by Michelle …
Evaluation Of Methods For The Restoration Of Native Grasslands On Abandoned Center Pivots In The Sandsage Prairies Of Southwestern Kansas, Alonso Barragan-Martinez
Evaluation Of Methods For The Restoration Of Native Grasslands On Abandoned Center Pivots In The Sandsage Prairies Of Southwestern Kansas, Alonso Barragan-Martinez
Master's Theses
Throughout southwestern Kansas thousands of acres of native grassland have been converted to cropland for agricultural use, reducing native prairie by over 60% in the sandsage prairie. Due to low precipitation and arid conditions, much of these croplands are irrigated by center pivot irrigation systems fed by the Ogallala Aquifer. These fields are abandoned when the aquifers dry up, resulting in erosion of the unused farmland. Conservation programs such as the Conservation Reserve Enhancement Program (CREP) were established to address this problem but have been unsuccessful in restoring native grasslands in abandoned croplands in southwestern Kansas. We hypothesized that insect …
Investigating The Function Of Carboxypeptidase O Gene Paralogs From Xenopus Tropicalis, Ritchie Saint Jean
Investigating The Function Of Carboxypeptidase O Gene Paralogs From Xenopus Tropicalis, Ritchie Saint Jean
Master's Theses
Carboxypeptidase O (CPO) is a peptidase that is a member of the A/B subfamily of the metallocarboxypeptidases. This peptidase has been found in the brush border of the intestine and has specificity toward C-terminal acidic residues. CPO has been proposed to be involved in intestinal digestion and the formation of lipid droplets. Four copies of the CPO gene are present in the Xenopus tropicalis (tropical clawed frog) genome and are noted as CPO.1, CPO.2, CPO.3, and CPO.4. Not much is known about these genes regarding their properties and functions. In my research, I sought to investigate the properties and functions …
An Investigation Into Historical And Contemporary Breeding Occurrence Of The Ferruginous Hawk In Kansas, Erica Clark
An Investigation Into Historical And Contemporary Breeding Occurrence Of The Ferruginous Hawk In Kansas, Erica Clark
Master's Theses
The Ferruginous Hawk (Buteo regalis) is the largest Buteo species occurring in grasslands, nesting along bluffs, buttes and isolated trees. In Kansas, the Ferruginous Hawk is listed as a Species of Greatest Conservation Need, Tier II. A previous study on Ferruginous Hawks nesting in Kansas during the years of 1979 to 1987, with sporadic visits from the 1990s to 2000, revealed that the most productive nesting territories were inaccessible to predators, placed on rocky ledges and the surrounding landscape was over 50% rangeland. I revisited 82 of the 111 historic nest territories in the summers of 2019 and …