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Reproductive And Mutagenic Effects Of 5-Thio-D-Glucose Injections In Male Mice, Mus Musculus, Icr Strain, Mary E. Mcmanaway

Master's Theses

Adult male ICR mice of proven fertility were intraperitoneally injected daily with 60 mg/kg of 5-thio-D-glucose for 28 days. Body weights of treated male mice were unaffected during the experimental period. Relative testicular weights were significantly reduced at 121 days after initial injections in 5-thio treated males, but no significant decrease was observed at 28 days.

Onset of sterility was estimated to occur at approximately 4 weeks and persisted for 5 to 6 weeks after cessation of treatment at which time fertility was restored.

Beginning with the first injections and continuing for 121 days, the males were mated with untreated …