Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Biology
The Interacting Effects Of Tetraiodothyronine And Epinephrine On The Activities Of Na+ + K+ -Dependent Adenosine Triphosphatase, Hexokinase And Pyruvate Kinase In The Cardiac Tissue Of White Rats, Timothy Joseph Dietrick
The Interacting Effects Of Tetraiodothyronine And Epinephrine On The Activities Of Na+ + K+ -Dependent Adenosine Triphosphatase, Hexokinase And Pyruvate Kinase In The Cardiac Tissue Of White Rats, Timothy Joseph Dietrick
Master's Theses
The interacting effects of tetraiodothyronine (T4) and epi- nephrine on Na++K+-dependent ATPase, hexokinase, and pyruvate kinase in cardiac tissue of white rats were investigated in an attempt to elucidate the hormonal regulation of heart metabolism. Previous evidence has shown that 90% of the increase in oxygen consumption exhibited by hyperthyroid rats was due to an activation of Na++K+- dependent ATPase. In addition, hypothyroidism in sheep was re ported to lower cardiac Na++K+-dependent ATPase activity as well as 8-adrenergic binding sites for epinephrine. As T4 and epinephrine enhance carbohydrate metabolism, hexokinase and pyruvate kinase, two essentially irreversible glycolytic enzymes, were also …