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Vascular Endothelial Cell Growth Factor Expression In Endothelial Cells Is Induced By Mechanical Wounding, Paul J. Sammak, Phuong Oanh Tran, Timothy A. Olson

Journal of the Minnesota Academy of Science

Endothelial cell motility is central to several biological processes including angiogenesis during wound healing, reendothelialization of vessel walls after damage and neovascularization of tumors. However, control mechanisms that stimulate and inhibit cell movement are not known. Our objective is to understand the signals that initiate movement of endothelial cells. To examine these questions, we used an in vitro wound model of quiescent pulmonary artery endothelial cell monolayers which were stimulated to move by mechanical injury. Ca2+ signaling at the time of wounding produces long lasting effects on cell movement. We investigated whether new gene transcription after wounding might also stimulate …