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Articles 1 - 7 of 7
Full-Text Articles in Biology
Restoring Polyhyrdoxybutyrate (Phb) Depolymerase Expression In A Bald Mutant Of Streptomyces Sp. Sfb5a, Youmna Moawad
Restoring Polyhyrdoxybutyrate (Phb) Depolymerase Expression In A Bald Mutant Of Streptomyces Sp. Sfb5a, Youmna Moawad
Honors Projects
Polyhydroxybutyrate (PHB) is a biodegradable, plastic-like polymer produced by some bacteria and degraded by others. The filamentous bacterium Streptomyces sp. SFB5A degrades PHB for growth using an extracellular PHB depolymerase, encoded by the phaZ gene. A morphological mutant of this bacterium, bld4, cannot form aerial filaments and cannot produce PHB depolymerase, despite having the phaZ gene. The inability to synthesize PHB depolymerase may be due to a mutation in a gene encoding one of its transcriptional regulators. A gene (lrp) coding for a potential transcriptional regulator is located 2,700 base pairs upstream from phaZ. Our goal …
The Scoop On Composting: A Comprehensive Literature Review On Composting With A Focus On Grand Valley State University, Alexandria Snabes
The Scoop On Composting: A Comprehensive Literature Review On Composting With A Focus On Grand Valley State University, Alexandria Snabes
Honors Projects
This comprehensive review discusses the main microbial processes, methods, efficiency strategies, benefits, and drawbacks related to composting. Specifically, anaerobic, aerobic, and intermediate, or cold composting, decomposition processes are defined and assessed. This leads into a discussion of some common methods of composting, both large- and small-scale, which utilize these microbial processes to result in differing advantages and disadvantages. The efficiency of these methods can be increased using strategies that monitor oxygen levels, moisture levels, temperate levels, and overall size. Some benefits of composting discussed include diverting waste from landfills, improving soil nutrition and quality long-term, and increasing plant growth and …
Open System Metabolism Of The Grand River From Headwaters To Mouth, Colin J. Assenmacher
Open System Metabolism Of The Grand River From Headwaters To Mouth, Colin J. Assenmacher
Honors Projects
The Grand River is the longest river in Michigan and has been greatly impacted by human activities, particularly logging in the mid-1800s, which when coupled with 20th-century urbanization and continued agricultural use, led to historically poor river health. Despite this, actions throughout the past 50 years by federal, state, and local citizen involvement, have resulted in increased river health and broader water quality monitoring within the watershed. During the summer of 2021, rapid bioassessments targeting benthic macroinvertebrates were conducted along the Grand River, with the primary goal of following up on prior state-led surveys conducted at different locations along the …
Expression And Purification Of N-Terminally Acetylated Microtubule Binding Protein Tau, Abigail Fleurima
Expression And Purification Of N-Terminally Acetylated Microtubule Binding Protein Tau, Abigail Fleurima
Honors Projects
The microtubule-associated protein Tau (MAPT) plays a critical role in many neurodegenerative diseases. Tau functions to stabilize microtubule structures that are essential for transport within the neuron, and transport disruption leads to loss of neuronal function. Tau binding is regulated by phosphorylation with the help of kinases that add phosphate groups which block microtubule binding sites, and phosphatases that remove phosphate groups and expose the microtubule-binding regions. Tau can be found in hyper-phosphorylated states, which causes Tau to self-assemble into aggregates and prevent microtubule binding. It's clear that post-translational modifications (PTMs) of Tau play a key role in the dysregulation …
Function Of Spiny Dorsal Fin Erector Muscles In The Bluegill, Lepomis Macrochirus, Zakiyat Djabakatie
Function Of Spiny Dorsal Fin Erector Muscles In The Bluegill, Lepomis Macrochirus, Zakiyat Djabakatie
Honors Projects
Local motor control directly contributes to stability, which can be compromised by injury or multiple neuromuscular disorders. In addition, lack of sensory perception as experienced by decreased limb sensation can further deteriorate one‚Äôs quality of life. The goal of this study is to use bluegill (Lepomis macrochirus) fins as model systems to study and gain insights on local motor control and sensory perception to improve stability and locomotion in humans, especially in a rehabilitative state. We hypothesize that 1) when exposed to turbulence (T), bluegill will use the spiny dorsal fin to recover stability and muscle intensity and duration will …
Shelter Dogs Need A Home: The Effect Of Enrichment And Human Contact On The Welfare And Adoptability Of Shelter Dogs, Hannah G. Clark
Shelter Dogs Need A Home: The Effect Of Enrichment And Human Contact On The Welfare And Adoptability Of Shelter Dogs, Hannah G. Clark
Honors Projects
It comes as no surprise that an animal shelter can be a stressful place for dogs. Shelter conditions, accompanied by multiple, novel stimuli, produce a stressful environment that cause hormonal and behavioral responses in dogs housed in shelters. Many of the stereotypical behaviors produced by the stress of living in a shelter, which tend to worsen as length of stay increases, are undesirable to potential adopters. However, many studies have shown that enrichment with a variety of toys, exercise, and human interaction can buffer the stress response in shelter dogs and improve their well-being. Implementing obedience training and temporary fostering …
Induced Pluripotent Stem Cell Cardiomyocytes Provide An In Vitro Model Of The Myocardial Environment For Investigating Stem Cell Therapies, Jacob M. Gunn
Honors Projects
Ischemic heart disease remains a major cause of death and disability worldwide (Moran Andrew E. et al., 2014). While interventions for heart disease have come a long way, restoring functionality to damaged myocardium remains a challenge. Both mechanical and electrical repair of the host myocardium are essential to salvage the damaged tissue. This is especially difficult following a myocardial infarction (MI) as the infarct area is subject to quick and extensive cell death via necrosis then apoptosis (Prabhu & Frangogiannis, 2016). Stem cells have emerged as a candidate for potential replacement therapies. Adult stem cells (ASCs) are taken from bone …