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K+- Induced Dilation Of Cremasteric Arterioles Involves Na+/K+Atpase And Inward Rectifier K+ Channels, Wendy Burns
K+- Induced Dilation Of Cremasteric Arterioles Involves Na+/K+Atpase And Inward Rectifier K+ Channels, Wendy Burns
Dissertations
The purpose of this study was to evaluate the possible mechanisms involved in cremasteric arteriolar dilation as a result of increased concentrations of ([K+]o) extracellular potassium. Many other studies suggested that Na+/K+ ATPase or KIR channels are responsible for potassium-induced vasodilation in other systems (2, 12, 22, 40, 46, 52, 16, 17, 25, 33, 34, 85, 99, 151). However, these studies show only partial inhibition of dilation as a result of independent blockageof each mechanism. The hypothesis of this study was that both mechanisms contribute to potassium-induced dilation seen in cremasteric arterioles. …
Cellular Proliferation, Death And Histology In Gambusia Affinis Livers After Exposure To 2-Aminofluorene And Benzidine, Susan J. Lentz
Cellular Proliferation, Death And Histology In Gambusia Affinis Livers After Exposure To 2-Aminofluorene And Benzidine, Susan J. Lentz
Dissertations
A fundamental need exists for aquatic animals in the biomonitoring of aquatic ecosystems for environmental carcinogens. G. affinis, a small fish species, is selected for this study due to its hardiness, non-migratory nature, geographic diversity and ability to develop tumors. Molecular tools for cellular proliferation and death are examined for use with G. affinis. Additionally, these tools are used to investigate the early carcinogenic effects of 2-aminofluorene and benzidine, both individually and combined, on G. affinis livers.
Antibodies to proliferating cell nuclear antigen (PCNA), p53, cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP) were examined for use in G. …