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- TRF (2)
- Trypanosoma brucei (2)
- 1Myb domain (1)
- Antigenic variation (1)
- Biotic resistance (1)
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- Clinical biomarker (1)
- DNA binding activity (1)
- Disturbance (1)
- Diversity (1)
- Genome stability (1)
- Invasion management (1)
- Maurer’s clefts (1)
- Mechanical control (1)
- PfMC-2TM (1)
- Plasmodium falciparum (1)
- Plasmodium membrane proteins (1)
- Protein trafficking (1)
- RAP (1)
- RAP1 (1)
- Solidago gigantea (1)
- Tanacetum vulgare Implications (1)
- Telomere (1)
- VSG telomere (1)
Articles 1 - 6 of 6
Full-Text Articles in Biology
Regulation Of Antigenic Variation By Trypanosoma Brucei Telomere Proteins Depends On Their Unique Dna Binding Activities, Bibo Li Ph.D., Yanxiang Zhao
Regulation Of Antigenic Variation By Trypanosoma Brucei Telomere Proteins Depends On Their Unique Dna Binding Activities, Bibo Li Ph.D., Yanxiang Zhao
Biological, Geological, and Environmental Faculty Publications
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response. Such antigenic variation is a key pathogenesis mechanism that enables T. brucei to establish long-term infections. VSG is expressed exclusively from subtelomere loci in a strictly monoallelic manner, and DNA recombination is an important VSG switching pathway. The integrity of telomere and subtelomere structure, maintained by multiple telomere proteins, is essential for T. brucei viability and for regulating the monoallelic VSG expression and VSG switching. Here we will focus on T. brucei TRF and RAP1, two telomere …
Keeping Balance Between Genetic Stability And Plasticity At The Telomere And Subtelomere Of Trypanosoma Brucei, Bibo Li Ph.D.
Keeping Balance Between Genetic Stability And Plasticity At The Telomere And Subtelomere Of Trypanosoma Brucei, Bibo Li Ph.D.
Biological, Geological, and Environmental Faculty Publications
Telomeres, the nucleoprotein complexes at chromosome ends, are well-known for their essential roles in genome integrity and chromosome stability. Yet, telomeres and subtelomeres are frequently less stable than chromosome internal regions. Many subtelomeric genes are important for responding to environmental cues, and subtelomeric instability can facilitate organismal adaptation to extracellular changes, which is a common theme in a number of microbial pathogens. In this review, I will focus on the delicate and important balance between stability and plasticity at telomeres and subtelomeres of a kinetoplastid parasite, Trypanosoma brucei, which causes human African trypanosomiasis and undergoes antigenic variation to evade the …
The Ecology Of Rural Roads: Effects, Management, And Research, Alisa W. Coffin, Douglas S. Ouren, Neil D. Bettez, Luís Borda-De-Água, Amy E. Daniels, Clara Grilo, Jochen A.G. Jaeger, Laetitia M. Navarro, Haiganoush K. Preisler, Emily Rauschert
The Ecology Of Rural Roads: Effects, Management, And Research, Alisa W. Coffin, Douglas S. Ouren, Neil D. Bettez, Luís Borda-De-Água, Amy E. Daniels, Clara Grilo, Jochen A.G. Jaeger, Laetitia M. Navarro, Haiganoush K. Preisler, Emily Rauschert
Biological, Geological, and Environmental Faculty Publications
No abstract provided.
Intense Mowing Management Suppresses Invader, But Shifts Competitive Resistance By A Native To Facilitation, David U. Nagy, Emily Rauschert, Ragan M. Callaway, Tamas Henn, Rita Filep, Robert W. Pal
Intense Mowing Management Suppresses Invader, But Shifts Competitive Resistance By A Native To Facilitation, David U. Nagy, Emily Rauschert, Ragan M. Callaway, Tamas Henn, Rita Filep, Robert W. Pal
Biological, Geological, and Environmental Faculty Publications
Interactions among native and invasive species may affect management outcomes and goals. We implemented different mowing regimes to control the invasive Solidago gigantea and restore natural diversity, and also examined interactions between Solidago and a European native competitor, Tanacetum vulgare in the context of these regimes. Experimentally planted Tanacetum suppressed Solidago by 79% without management, and a suite of mowing management regimes reduced the density of Solidago by 80–98% when Tanacetum was absent. But, when Tanacetum was added, the density of the invader was not reduced by mowing. Put another way, in mowed plots with Tanacetum, Solidago was twofold to …
Trafficking And Association Of Plasmodium Falciparum Mc-2tm With The Maurer’S Clefts, Raghavendra Yadavalli, John W. Peterson, Judith A. Drazba, Tobili Y. Sam-Yellowe
Trafficking And Association Of Plasmodium Falciparum Mc-2tm With The Maurer’S Clefts, Raghavendra Yadavalli, John W. Peterson, Judith A. Drazba, Tobili Y. Sam-Yellowe
Biological, Geological, and Environmental Faculty Publications
In this study, we investigated stage specific expression, trafficking, solubility and topology of endogenous PfMC-2TM in P. falciparum (3D7) infected erythrocytes. Following Brefeldin A (BFA) treatment of parasites, PfMC-2TM traffic was evaluated using immunofluorescence with antibodies reactive with PfMC-2TM. PfMC-2TM is sensitive to BFA treatment and permeabilization of infected erythrocytes with streptolysin O (SLO) and saponin, showed that the N and C-termini of PfMC-2TM are exposed to the erythrocyte cytoplasm with the central portion of the protein protected in the MC membranes. PfMC-2TM was expressed as early as 4 h post invasion (hpi), was tightly colocalized with REX-1 and trafficked …
Gene Variants Of Coagulation Related Proteins That Interact With Sars-Cov-2, David Holcomb, Aikaterini Alexaki, Nancy Hernandez, Ryan Hunt, Jacob Kames, Nobuko Hamasaki-Katagiri, Anton A. Komar, Michael Dicuccio, Chava Kimchi-Sarfaty
Gene Variants Of Coagulation Related Proteins That Interact With Sars-Cov-2, David Holcomb, Aikaterini Alexaki, Nancy Hernandez, Ryan Hunt, Jacob Kames, Nobuko Hamasaki-Katagiri, Anton A. Komar, Michael Dicuccio, Chava Kimchi-Sarfaty
Biological, Geological, and Environmental Faculty Publications
Increased blood clotting, especially in the lungs, is a common complication of COVID-19. Infectious diseases cause inflammation, which in turn can contribute to increased blood clotting. However, the extent of clot formation that is seen in the lungs of COVID-19 patients suggests that there may be a more direct link. We identified three human proteins that are involved indirectly in the blood clotting cascade and have been shown to interact with proteins of SARS virus, which is closely related to the novel coronavirus. We examined computationally the interaction of these human proteins with the viral proteins. We looked for genetic …