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Full-Text Articles in Biology
Impact Of Lyophilization On Porcine Hemoglobin Properties., Mustafa Almosawi
Impact Of Lyophilization On Porcine Hemoglobin Properties., Mustafa Almosawi
College of Arts & Sciences Senior Honors Theses
Blood transfusion is the single most often performed lifesaving procedure in hospitals worldwide. Unfortunately, packed red blood cells (RBCs) used for transfusion can only be stored for 42 days at 4 °C before being discarded due to irreversible damage that occurs during storage. Any reduction in available RBCs for an extended period can lead to blood shortages. To increase the shelf-life of RBCs, we investigated freeze-drying (lyophilizing) in the presence of the non-toxic sugar trehalose as a method for long-term preservation. However, the oxidative stress of the lyophilization and storage processes can compromise the functionality of these cells, and the …
The Emerging Oral Pathogen, Filifactor Alocis, Modulates Antimicrobial Responses In Primed Human Neutrophils., Ian J. Snider
The Emerging Oral Pathogen, Filifactor Alocis, Modulates Antimicrobial Responses In Primed Human Neutrophils., Ian J. Snider
College of Arts & Sciences Senior Honors Theses
Periodontitis is an irreversible, chronic inflammatory, infectious disease of the oral cavity that affects approximately half of all adults 30 years or older in the USA. The oral cavity is under high immune surveillance because of its constant exposure to microbes in the environment. The primary immune cell responsible for this surveillance is the neutrophil. Pathogens associated with periodontitis possess virulence factors and have evolved strategies to evade neutrophil antimicrobial responses to survive. One such pathogen is Filifactor alocis, whose presence is associated with the progression of periodontitis. F. alocis manipulates several neutrophil antimicrobial functional responses to avoid killing, an …
Impacts Of Dietary Restriction On A Drosophila Model Of Werner Syndrome, Eileen Sember
Impacts Of Dietary Restriction On A Drosophila Model Of Werner Syndrome, Eileen Sember
College of Arts & Sciences Senior Honors Theses
Werner syndrome (WS) is an autosomal recessive disorder that results in premature aging and occurs in 1 in 1,000,0000 to 1 in 10,000,000 people. In humans, WS is the result of mutations that render the WRN gene, that contains a helicase and an exonuclease domain, non-functional. Currently, there is no cure for WS in humans, making dietary and lifestyle interventions attractive for increasing the quality and longevity of lives. Diet restriction (DR) has been shown to extend the lifespan of several model organisms, including Drosophila melanogaster, making it a strong candidate for WS treatment. In this thesis, mutant flies …