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Effects Of Ethanol And Caffeine Administered Maternally On Neonatal Adrenocortical Function, Rhonda L. Mullins Rohlfing
Effects Of Ethanol And Caffeine Administered Maternally On Neonatal Adrenocortical Function, Rhonda L. Mullins Rohlfing
Biological Sciences Theses & Dissertations
Two investigations were conducted to determine the effects of maternally administered ethanol and caffeine on neonatal adrenocortical function. In the ethanol study, pregnant female rats were fed a liquid diet in which 35% of the sucrose calories were removed and replaced with ethanol. Dams in the caffeine study were injected with 25 mg/kg/day caffeine in saline solution. Within 24 hours of parturition, neonatal rats in both studies were sacrificed. The adrenal glands were incubated in vitro for one hour and media were analyzed for corticosterone content. Significant adrenal weight differences were found in both studies. The ethanol group pups were …
Acetylcholinesterase In The Neonatal Rat Brain: The Effects Of Prenatal Ethanol Exposure, Linda M. Boland
Acetylcholinesterase In The Neonatal Rat Brain: The Effects Of Prenatal Ethanol Exposure, Linda M. Boland
Biological Sciences Theses & Dissertations
Acetylcholinesterase (AChE) activity in the neonatal rat brain was determined by histochemical localization and quantitative biochemical analysis. AChE-positive perikarya were concentrated in the neostriatum, globus pallidus, medial habenular nucleus, amygdaloid complex, various hypothalamic nuclei, gigantocellular and paragigantocellular reticular nuclei, raphe nuclei, locus coeruleus, and motor nuclei of cranial nerves III-VII and IX-XII. Some areas stained differently or not at all when compared with the adult rat brain. The effects of prenatal ethanol exposure on regional AChE activity were assessed by comparing enzyme levels in offspring exposed via maternal consumption of a liquid diet containing 35 percent ethanol derived calories. This …