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The Functional Role Of Peripheral Nerves In Ige-Mediated Inflammation, Gary Wright Miller
The Functional Role Of Peripheral Nerves In Ige-Mediated Inflammation, Gary Wright Miller
Biological Sciences Theses & Dissertations
IgE-mediated inflammation was measured in mouse footpads with and without sciatic innervation. Mice were passively sensitized with IgE anti-dinitrophenol, a monoclonal antibody. Antigen-induced swelling was reduced by 26% by sciatic nerve transection. Whether transection occurred 10 days prior or immediately prior to antigen challenge did not affect the swelling response. The full inflammatory response was restored by antidromic stimulation of the distal portion of the cut nerve, but only in the freshly cut nerve. Antigen-induced swelling was unaffected by rhizotomy or spinal nerve transection. Pre-treatment with capsaicin reduced the swelling to a level similar to sciatic nerve transection. Treatment with …
Evidence Of A Neurogenic Component During Ige-Mediated Inflammation In Murine Skin, Victoria Jean Cavanaugh
Evidence Of A Neurogenic Component During Ige-Mediated Inflammation In Murine Skin, Victoria Jean Cavanaugh
Biological Sciences Theses & Dissertations
The direct stimulation of sensory nerves or the intradermal injection of neuropeptides triggers a cutaneous inflammatory response that involves the degranulation of mast cells. These neurogenic inflammatory reactions are physiologically similar to IgE-mediated hypersensitivity responses, which also depend on mast cells. Although non-antigenic stimuli distinguish neurogenic from IgE-mediated inflammation, the similarity of their effector stages suggested that peripheral nerves may also participate in lgE-mediated responses. To examine this hypothesis, IgE responses were elicited in denervated skin. A murine model was developed where the footpad was denervated by surgically removing a 2 mm segment of the sciatic nerve, proximal to the …