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Articles 1 - 14 of 14
Full-Text Articles in Biology
Reproductive Life History And Shell Shape Variation Of Three Species Of Elimia (Pleuroceridae) In The Lower Etowah River Basin, Ellen Winant
Reproductive Life History And Shell Shape Variation Of Three Species Of Elimia (Pleuroceridae) In The Lower Etowah River Basin, Ellen Winant
Master of Science in Integrative Biology Theses
Pleurocerid snail diversity in the Southeastern United States is thought to be high, but estimates of overall diversity are compromised by uncertain taxonomy. This is particularly true for the genus Elimia, where reliance on conchological characters described by early naturalists for species designation failed to recognize significant variability in shell morphology. In this study we examine three putative species of Elimia to determine if quantifiable conchological characters are associated with differences in life history characteristics. Individuals of E. modesta, E. carinocostata, and E. cariniferawere collected from nine sites in three streams in the lower Etowah River …
The Role Of Cnd-1/Neurod1 In C. Elegans Nervous System Development, Wendy Aquino Nunez
The Role Of Cnd-1/Neurod1 In C. Elegans Nervous System Development, Wendy Aquino Nunez
Master of Science in Integrative Biology Theses
NeuroD1 is a vertebrate helix-loop-helix transcription factor that is involved in nervous system development and pancreatic islet development. NeuroD1 -/- mice is uncoordinated, has seizures and a reduce brain size (Miyata et al. 1999). In C. elegans, the ortholog gene is cnd-1. Hallam et al. 2000, showed that cnd-1 has a role in cell fate determination of GABAergic, DD motor neurons, in addition to a role in axon morphology. cnd-1(ju29) worms, show GABAergic motor neuron defect, they have a “kinky” backward movement phenotype and their axons are branched. However, only three genes are known to be downstream targets of …
Effects Of Drift Macroalgae On Sediment Nitrogen Cycling In Thalassia Testudinum Beds Of St. Joseph Bay, Fl, Erica Strope
Effects Of Drift Macroalgae On Sediment Nitrogen Cycling In Thalassia Testudinum Beds Of St. Joseph Bay, Fl, Erica Strope
Master of Science in Integrative Biology Theses
Anthropogenic nitrogen (N) loading and eutrophication can affect valuable ecosystem services and seagrass habitats by modifying structural and functional aspects of estuarine communities including increasing and prolonging macroalgae blooms. In some contexts, macroalgae may play a key role in N cycling pathways because they can alter sediment chemistry. Previous research has associated drift macroalgae blooms with elevated dissolved inorganic N concentrations in sediments as a result of increased remineralization of organic matter, but drift macroalgae effects on microbial N transformation pathways are not well understood. This study quantified the effects of macroalgae on estuarine N cycling in Thalassia testudinum seagrass …
Modeling And Mapping Addiction In The Zebrafish, Danio Rerio, Bradley Serpa
Modeling And Mapping Addiction In The Zebrafish, Danio Rerio, Bradley Serpa
Master of Science in Integrative Biology Theses
Driven by the communication of dopamine, the vertebrate reward system has been evolutionarily conserved to maintain survival and optimize fitness. The neural circuits governing this system integrate sensory stimuli to produce appropriate, self-preserving responses that underlie experience-based learning. In the most primitive vertebrates, dopamine release in neuronal circuits drives homeostatic behaviors, such as seeking nutrients, finding a mate, or avoiding danger. From agnathans to mammals, dopaminergic synthesis and signaling genes and molecules, along with neuronal pathways and reward system-based behaviors, remain highly conserved. Dopamine signaling proteins include two classes of metabotropic G-Protein Receptor Coupled Dopamine Receptors, D1-like (DRD1) and D2-like …
Novel Applications Of Biolayer Interferometry To Investigate Molecular Interactions, Mareena M. Pitts
Novel Applications Of Biolayer Interferometry To Investigate Molecular Interactions, Mareena M. Pitts
Master of Science in Integrative Biology Theses
In this study, BLI is used to explore various molecular interactions to demonstrate molecular binding and to provide quantitative characterization of binding kinetics and affinities of phage-protein and DNA-protein interactions. The results of this study demonstrate novel use of biolayer interferometry to immobilize whole Sf6 bacteriophage onto the biosensor to measure the binding to its outer membrane host receptor protein OmpA. The use of BLI also demonstrates the technology as a probe to predict and verify binding interactions at the molecular level to assign the role of protein function in both Vibrio fischeri and Pseudomonas aeruginosa. Each aim of this …
Book Review - Coyote Settles The South, Cheryl Stiles
Book Review - Coyote Settles The South, Cheryl Stiles
Georgia Library Quarterly
No abstract provided.
Selective Muscle Degeneration In A Drosophila Model Of Cachexia; A Role For The Transcriptional Regulator Cabut, Matthew Giedd
Selective Muscle Degeneration In A Drosophila Model Of Cachexia; A Role For The Transcriptional Regulator Cabut, Matthew Giedd
Master of Science in Integrative Biology Theses
Cachexia is a systemic metabolic syndrome characterized by progressive muscle wasting. Cachectic muscle wasting presents as a comorbidity with pathological illnesses like cancer, chronic inflammation, and type 2 diabetes. The development of cachexia complicates treatment of these diseases and worsens clinical outcomes. Thus, it has become the focus of intense investigation. While many of the upstream mechanisms that propagate cachectic muscle wasting have been brought to light, little is known of the downstream mechanisms which would be more clinically relevant. Here, we have adopted a Drosophila model of cachectic muscle wasting to elucidate a novel role of the transcriptional regulator, …
An Integrative Approach To Evaluating Radiocesium Contamination In Fukushima Prefecture, James Thornhill
An Integrative Approach To Evaluating Radiocesium Contamination In Fukushima Prefecture, James Thornhill
Master of Science in Integrative Biology Theses
An earthquake in Japan led to the meltdown of the Fukushima Daiichi Nuclear Power Plant which released radionuclides into the surrounding regions. Of these radionuclides, cesium-137 (137Cs+) has been shown to be the most abundant. Research has shown that adsorption of K+ and Cs+ on 2:1 clay minerals can collapse the interlayers, causing the adsorbed ion to become non-exchangeable. This thesis takes an integrative approach to the restoration of radiocesium-contaminated soil in three parts by 1) evaluating the adsorption behavior and mechanisms of Cs+ in vermiculite, 2) using plants as bioindicators to elucidate …
Transcending The Cell Fate Stereotype: Cell Penetrating Peptide Technology Helps Induce Pluripotency In Multiple Cell Types, Kelsey Clearman
Transcending The Cell Fate Stereotype: Cell Penetrating Peptide Technology Helps Induce Pluripotency In Multiple Cell Types, Kelsey Clearman
Master of Science in Integrative Biology Theses
Induced pluripotent stem cells (iPSCs) are one of the most promising new technologies in the field of regenerative medicine. iPSCs can be generated directly from a patient’s own fibroblast cells then converted into any cell type, thus overcoming challenges associated with embryonic stem cells and graft-vs-host disease that result from current methods. Generation of iPSCs from fibroblasts is traditionally accomplished by ectopic expression of four key transcription factors (TFs): Oct4, Sox2, Klf4, and c-Myc also known as OSKM. These TFs have been shown to be involved in maintaining pluripotency and inhibiting embryonic stem (ES) cell differentiation. Reprogramming fibroblasts into iPSCs …
Evolution Of Voltage-Gated Ion Channels, Kevin Gregory Bennett, Kevin Bennett
Evolution Of Voltage-Gated Ion Channels, Kevin Gregory Bennett, Kevin Bennett
Master of Science in Integrative Biology Theses
Voltage-gated Ion Channels (VICs) form a superfamily of energy-independent membrane transporters that facilitate the transfer of charged sodium, calcium, and potassium ions across the cell membrane (Hodgkin & Huxley 1952). The channels contain a selective ion-conducting pore along with several other structural and gating features that come together to form a functional hetero- or homotetramer. A comprehensive phylogenetic study of all available proteins aimed at finding unknown distribution and illuminating evolutionary paths would be immensely useful in understanding relationships of structure, function, and organismal distribution. This phylogenetic analysis of VICs will be immensely useful in characterizing functional and structural distribution, …
Effects Of Hypoxia On Swimming And Sensing In A Weakly Electric Fish, Kerri Lynn Ackerly, Rüdiger Krahe, Christopher P. Sanford, Lauren J. Chapman
Effects Of Hypoxia On Swimming And Sensing In A Weakly Electric Fish, Kerri Lynn Ackerly, Rüdiger Krahe, Christopher P. Sanford, Lauren J. Chapman
Faculty Articles
Low dissolved oxygen (hypoxia) can severely limit fish performance, especially aerobically expensive behaviours including swimming and acquisition of sensory information. Fishes can reduce oxygen requirements by altering these behaviours under hypoxia, but the underlying mechanisms can be difficult to quantify. We used a weakly electric fish as a model system to explore potential effects of hypoxia on swim performance and sensory information acquisition, which enabled us to non-invasively record electric signalling activity used for active acquisition of sensory information during swimming. To quantify potential effects of hypoxia, we measured critical swim speed (Ucrit) and concurrent electric signalling activity under highand …
Novel Use Of A Cell-Penetrating Peptide-Adaptor System To Characterize Akirin Constructs And Investigate Activity Of Bacterial Effector Proteins, Shaquanna Young
Novel Use Of A Cell-Penetrating Peptide-Adaptor System To Characterize Akirin Constructs And Investigate Activity Of Bacterial Effector Proteins, Shaquanna Young
Master of Science in Integrative Biology Theses
In the late 1980s, HIV protein TAT was found to confer the passage of HIV through the plasma membrane of mammalian cells. The McMurry lab developed a CPP-adaptor system which consists of the fusion of TAT to calmodulin to which mediates the delivery of exogenous proteins into cells and prevents endosomal entrapment. Calmodulin (CaM) is capable of binding to the calmodulin binding site (CBS) of cargo only in the presence of calcium. TAT-CaM can be used to characterize Akirin constructs and investigate the activity of bacterial effectors, AopP and AvrA, in the NF-kB pathway. Akirin is a small nuclear protein …
Evaluating In Situ Grazing Patterns Of Lytechinus Variegatus And Their Effects On Seagrass Beds Of Thalassia Testudinum, Adrianna Parson
Evaluating In Situ Grazing Patterns Of Lytechinus Variegatus And Their Effects On Seagrass Beds Of Thalassia Testudinum, Adrianna Parson
Master of Science in Integrative Biology Theses
The sea urchin Lytechinus variegatus is a known grazer of the seagrass Thalassia testudinum, and has been known to denude vast stands of seagrass beds at high densities. Outside of these denudation events, the effects of sea urchins on seagrass are poorly understood. This study examines the effects of L. variegatus on T. testudinum in situ, to understand how sea urchins are affecting seagrasses in situ. Results indicate that urchins were found in the offshore portion of the seagrass bed at densities up to 4 urchins/m2. Changes in temperature and sediment size in the bay indicate …
Investigating The Molecular Function Of Akirin During Skeletal Myogenesis In Drosophila Melanogaster, Kristina Rowland
Investigating The Molecular Function Of Akirin During Skeletal Myogenesis In Drosophila Melanogaster, Kristina Rowland
Master of Science in Integrative Biology Theses
The specification and differentiation of muscle precursor cells, or myoblasts, by the action of the mesodermal and muscle transcription regulator Twist is a key event in the formation of the Drosophila larval musculature. Akirin, a highly conserved nuclear protein, appears to play a critical role in the regulation of Twist-dependent gene expression during mesodermal specification and muscle development. Specifically, Akirin serves as a cofactor to promote interactions between regulatory transcription factors and multisubunit Brahma SWI/SNF-class chromatin remodeling complex to impact gene expression across varying targets. Using a genetic interaction screen in Drosophila, we have begun to identify other Akirin …