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Articles 1 - 4 of 4
Full-Text Articles in Biology
Novel Mechanistic Insight Into Ciliary Regulation: Old Pathways Yield New Mechanisms, Larissa L. Dougherty
Novel Mechanistic Insight Into Ciliary Regulation: Old Pathways Yield New Mechanisms, Larissa L. Dougherty
Dartmouth College Ph.D Dissertations
Cilia are structures present on most eukaryotic cells which provide important signaling and motile components to cells from early development to fully differentiated and matured cells. Regulation of these structures is critical to proper functioning of the cell and is known to be tied to the cell cycle. Preparation for ciliary assembly following cell cycle exit and ciliary disassembly following cell cycle reentry requires components throughout the cell body and within the cilium to facilitate this process. Here I identify how the cell adapts to ensure modifications to cilia occur for assembly or disassembly using the model organism Chlamydomonas reinhardtii. …
Visual Ecology: Sensing The Social World, Elliott P. Steele
Visual Ecology: Sensing The Social World, Elliott P. Steele
Dartmouth College Ph.D Dissertations
Social animals, and even solitary animals, must at different points in their life actively search for and locate conspecifics within their environment, using one or multiple senses. One sense in particular, vision, can provide some of the most spatially detailed and temporally rapid information about the environment. Yet, the surrounding environment can also severely challenge animals’ abilities to find fellow conspecifics. Furthermore, once an animal successfully locates conspecifics, it must then make key decisions about when and where to enter group formations, decisions which may strongly impact their access to socially-acquired resources. Even after an animal has positioned itself within …
Ecology And Evolution Of Social Information Use, Clare T. M. Doherty
Ecology And Evolution Of Social Information Use, Clare T. M. Doherty
Dartmouth College Ph.D Dissertations
Sociality is a strategy many animals employ to cope with their environments, enabling them to survive and reproduce more successfully than would otherwise be possible. When navigating their environments and making decisions, social individuals often use information provided by conspecifics (in the form of social cues and signals), thereby increasing the scope and reliability of the information they can gather. However, social information use may be influenced by many factors, including key differences in context across the physical and social environment. My thesis asks and answers a series of questions regarding the trade-offs in social information use across different contexts, …
A Multi-Resolution Graph Convolution Network For Contiguous Epitope Prediction, Lisa Oh
A Multi-Resolution Graph Convolution Network For Contiguous Epitope Prediction, Lisa Oh
Dartmouth College Master’s Theses
Computational methods for predicting binding interfaces between antigens and antibodies (epitopes and paratopes) are faster and cheaper than traditional experimental structure determination methods. A sufficiently reliable computational predictor that could scale to large sets of available antibody sequence data could thus inform and expedite many biomedical pursuits, such as better understanding immune responses to vaccination and natural infection and developing better drugs and vaccines. However, current state-of-the-art predictors produce discontiguous predictions, e.g., predicting the epitope in many different spots on an antigen, even though in reality they typically comprise a single localized region. We seek to produce contiguous predicted epitopes, …