Biology Commons^™

Novel Heterocyclic Arylidene Derivatives As Anticancer Agents Against U87 Human Glioblastoma, Benjamin H. Hiramoto

Honors Theses

The primary objectives of this interdisciplinary study were the synthesis of novel heterocyclic arylidenes and the investigation of their anticancer activity against U87 glioblastoma cell viability. Recently, novel hybrid derivatives have been considered as potential candidates for treating glioblastoma, demonstrating a synergistic anticancer effect in previous studies. 12 heterocyclic arylidenes with various functional groups, including halogens and boronic acid, were produced via a Knoevenagel condensation. These compounds and their starting reagents were then administered to U87 glioblastoma cancer cells at graded concentrations within a 12-well cell viability assay to determine each compound’s lethal concentration 50 (LC50). The LC50 of each …

Evaluation Of Anticancer Activity Of Heterocyclic Arylidenes On The U87mg Cancer Cell Line, Bernadette Flores

Honors Theses

Glioblastoma multiforme, is a type of brain cancer that develops from glial cells, which surround neurons and provide support and insulation. Previous investigation has shown that some heterocyclic compounds are key in improving the properties of anticancer drugs by enhancing lipophilicity, polarity, and other varying physiochemical features. Synthetic heterocyclic compounds used as anticancer drugs attempt to imitate naturally-occurring ligands and substrates so as to disturb the natural balance in cells. Testing was done to determine the anticancer abilities of hybrid compounds, heterocyclic arylidenes, containing various functional groups, including boronic acids, through a three-day testing process. These compounds were previous synthesized …

Synthesis And Screening Of Novel Hybrid Benzothiazoles In U-87 Mg Glioblastoma Cell Line, Priscilla Kyi

Master's Theses

Benzothiazole is a heteroaromatic compound known for its wide range of bioactivities including anti-cancer, anti-viral, anti-microbial, anti-inflammatory, anti-convulsant, anti-diabetic, anti-helminthic, and anti-tubercular activities. Research has shown that derivatives of benzothiazole exhibit inhibition of proliferation via apoptosis in various human cancer cell lines, such as liver cancer (Wang, et. al., 2011). In this study, a series of novel hybrid benzothiazole α-cyanostilbene derivatives and styrylbenzothiazole derivatives containing boronic acid and non-boronic acid pharmacophores were synthesized. The anti-cancer and anti-invasive properties of selected benzothiazole α-cyanostilbene derivatives on U-87MG glioblastoma cells were investigated in vitro.

U-87MG cells were incubated with synthesized novel hybrid compounds …

Synthesis Of A-Cyanostilbenes And Testing Of Their Anticancer Properties, Gabrielle Cook

Honors Theses

This research project involves synthesizing cyanostilbenes and testing their anticancer properties in breast cancer cells. Breast cancer is a global issue, one that great improvement has been found in the last few decades, but also one that remains a large killer. The components of the cyanostilbene hybrids have all been shown to have anticancer properties on their own, and we would like to see if we can increase these properties by combining multiple into a single hybrid. Then these cyanostilbene compounds are tested on Her2+ human breast cancer cells. The goals is to assess whether or not the cyanostilbenes have …