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The Analysis Of Partial Dominance Of Intragenic Mutations At The Adh Locus In Drosophila Melanogaster At Two Different Alcohol Concentrations, Vatan Taşkin

Turkish Journal of Biology

The dominance of a de novo mutation determines its effect on the viability of the first and succeeding generations; therefore, it is a major factor in estimating the risk from mutations to human health. It is well established that large deletions lead to significant dominance, but until the recent development of molecular methods for amplification and sequencing of mutations it was not possible to determine the dominance of specific intragenic changes in DNA. The purpose of this study was to determine the dominance for a series of Adh-null mutations, each with a minimum mutation of a transition at one base …