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The Number Of X Chromosomes Causes Sex Differences In Adiposity In Mice, Jenny Link, Xuqi Chen, Rebecca Mcclusky, Simon W. Beaven, Peter Tontonoz, Arthur P. Arnold, Karen Reue
The Number Of X Chromosomes Causes Sex Differences In Adiposity In Mice, Jenny Link, Xuqi Chen, Rebecca Mcclusky, Simon W. Beaven, Peter Tontonoz, Arthur P. Arnold, Karen Reue
Biology
Sexual dimorphism in body weight, fat distribution, and metabolic disease has been attributed largely to differential effects of male and female gonadal hormones. Here, we report that the number of X chromosomes within cells also contributes to these sex differences. We employed a unique mouse model, known as the “four core genotypes,” to distinguish between effects of gonadal sex (testes or ovaries) and sex chromosomes (XX or XY). With this model, we produced gonadal male and female mice carrying XX or XY sex chromosome complements. Mice were gonadectomized to remove the acute effects of gonadal hormones and to uncover effects …