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Full-Text Articles in Biology
Gastrin Induces Nuclear Export And Proteasomal Degradation Of Menin In Enteric Glial Cells, Sinju Sundaresan, Cameron A. Meininger, Anthony J. Kang, Amanda L. Photenhauer, Michael M. Hayes, Nirakar Sahoo, Jolanda Lindenberg, Jolanta Grembecka, Tomasz Cierpicki, Lin Ding
Gastrin Induces Nuclear Export And Proteasomal Degradation Of Menin In Enteric Glial Cells, Sinju Sundaresan, Cameron A. Meininger, Anthony J. Kang, Amanda L. Photenhauer, Michael M. Hayes, Nirakar Sahoo, Jolanda Lindenberg, Jolanta Grembecka, Tomasz Cierpicki, Lin Ding
Biology Faculty Publications and Presentations
Background & aims: The multiple endocrine neoplasia, type 1 (MEN1) locus encodes the nuclear protein and tumor suppressor menin. MEN1 mutations frequently cause neuroendocrine tumors such as gastrinomas, characterized by their predominant duodenal location and local metastasis at time of diagnosis. Diffuse gastrin cell hyperplasia precedes the appearance of MEN1 gastrinomas, which develop within submucosal Brunner's glands. We investigated how menin regulates expression of the gastrin gene and induces generation of submucosal gastrin-expressing cell hyperplasia.
Methods: Primary enteric glial cultures were generated from the VillinCre:Men1FL/FL:Sst-/- mice or C57BL/6 mice (controls), with or without inhibition of gastric acid by omeprazole. Primary …
Co-Independent Modification Of K+ Channels By Tricarbonyldichlororuthenium(Ii) Dimer (Corm-2), Guido Gessner, Nirakar Sahoo, Sandip M. Swain, Gianna Hirth, Roland Schönherr, Ralf Mede, Matthias Westerhausen, Hans Henning Brewitz, Pascal Heimer, Diana Imhof
Co-Independent Modification Of K+ Channels By Tricarbonyldichlororuthenium(Ii) Dimer (Corm-2), Guido Gessner, Nirakar Sahoo, Sandip M. Swain, Gianna Hirth, Roland Schönherr, Ralf Mede, Matthias Westerhausen, Hans Henning Brewitz, Pascal Heimer, Diana Imhof
Biology Faculty Publications and Presentations
Although toxic when inhaled in high concentrations, the gas carbon monoxide (CO) is endogenously produced in mammals, and various beneficial effects are reported. For potential medicinal applications and studying the molecular processes underlying the pharmacological action of CO, so-called CO-releasing molecules (CORMs), such as tricabonyldichlororuthenium(II) dimer (CORM-2), have been developed and widely used. Yet, it is not readily discriminated whether an observed effect of a CORM is caused by the released CO gas, the CORM itself, or any of its intermediate or final breakdown products. Focusing on Ca2+- and voltage-dependent K+ channels (KCa1.1) and voltage-gated K+ channels (Kv1.5, Kv11.1) relevant …
Fish Oil With Higher Dha Content And Voluntary Exercise Decreases Postmenopausal Bone Loss, Jameela Banu, Gabriel Fernandes
Fish Oil With Higher Dha Content And Voluntary Exercise Decreases Postmenopausal Bone Loss, Jameela Banu, Gabriel Fernandes
Biology Faculty Publications and Presentations
There is increasing evidence suggesting that fish oil (FO) decreases bone resorption by reducing osteoclastogenesis and regular exercise (EX) increases bone mass. EX is associated with increasing bone formation. Therefore, the combined effects of FO intake and EX may have additive effects by both increasing bone formation and decreasing bone resorption. To demonstrate this, we studied the effects of FO and EX on the bone of mice after an ovariectomyinduced bone loss.
Twelve months old C57BL/6 female mice were either sham operated or ovariectomized, divided into different dietary and EX group and maintained for 3 months before sacrifice.
The distal …