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Articles 1 - 9 of 9
Full-Text Articles in Biology
Why New Diseases Keep Popping Up, Alan L. Gillen, Jason Conrad
Why New Diseases Keep Popping Up, Alan L. Gillen, Jason Conrad
Faculty Publications and Presentations
New and reemerging diseases are terrifying and concerning problems. Not only do they carry a financial and emotional toll, but they account for significant numbers of death. Emerging diseases are usually zoonotic and highly virulent in nature. These are pathogenic and parasitic diseases of high consequence and impact. Why would a good Creator allow these new diseases? Why do new diseases keep popping up? Mutation and displacement of original types of microbes account for many new diseases; however, the answer is more complex than just these two factors. Zoonoses are the most common type of infection, specifically from viral pathogens, …
Mrna Vaccinations For The Prevention Of Viral Infections, Isaac Underhill
Mrna Vaccinations For The Prevention Of Viral Infections, Isaac Underhill
Senior Honors Theses
mRNA vaccines for the prevention of infection disease have gained significant traction in the last three decades, specifically with the recent emergency approval of two COVID-19 vaccines (Oliver, Sara E et al., 2020; Rauch et al., 2018a). mRNA vaccines occupy a unique space in immunology because of their utilization of cellular mechanisms to produce viral proteins, and their simplicity and ease of manufacture (Cullis & Hope, 2017). These vaccines have shown strong humoral and cell-mediated adaptive immune responses (Rauch et al., 2018b) . In addition, side effects of the vaccines have been limited and subject response is manipulatable by varying …
Dna Aptamer-Drug Targeting Chemotherapy: Investigation Of Cell Cycle Inhibition Via S15 Aptamer – Norcantharidin Complex, Shannon Fehr
Dna Aptamer-Drug Targeting Chemotherapy: Investigation Of Cell Cycle Inhibition Via S15 Aptamer – Norcantharidin Complex, Shannon Fehr
Senior Honors Theses
Lung Cancer is the leading cause of cancer related death in both men and women in the United States (Bray et al., 2018). Cancer treatments are often non-specific and kill many dividing cells within a patient causing unwanted side effects. Norcantharidin (NCTD) is a synthetic FDA approved treatment for cancers including non-small cell lung cancers (NSCLC). NCTD suppresses cell proliferation by inhibiting cells from exiting the G2 phase of the cell cycle. Aptamers are short single-stranded DNA or RNA molecules with ligand directed self-annealing capabilities allowing selective binding to specific targets. This paper will discuss the hypothesized effects of using …
A Microbiome Analysis Of The Relationship Among Crayfish Ectosymbionts And Their Environment, John Hoverson
A Microbiome Analysis Of The Relationship Among Crayfish Ectosymbionts And Their Environment, John Hoverson
Senior Honors Theses
The purpose of this project was to determine if there are differences present between the α-diversities of the crayfish microbiome and its surrounding water and sediment. Furthermore, this project sought to discover if these differences hold when microbiomes are evaluated between crayfish of first and second stream orders. Finally, this project sought to determine if the presence of branchiobdellidan ectosymbionts on the crayfish caused further differences in the crayfish microbiome. While the hypothesized patterns between crayfish, ectosymbionts, and stream order were not found to exist, a significantly different microbiome was observed between water, sediment, and crayfish, and the α-diversity of …
Investigation Of Undocumented Heart Disease In Cadaveric Donors, Crystal Danae Passburg
Investigation Of Undocumented Heart Disease In Cadaveric Donors, Crystal Danae Passburg
Doctoral Dissertations and Projects
For nearly a century, heart disease has been the leading source of death and disease in the United States, causing the deaths of hundreds of thousands of individuals every year and burdening millions more with diminished health and severe disability. However, despite the significant known prevalence of heart disease, studies suggest that many more individuals—and particularly those within the female and elderly populations—may possess undiagnosed heart disease which remains undetected even after death due to the lack of autopsy examination. In the absence of autopsy, many cases of heart disease may never be identified, resulting in a skewed understanding of …
Spinal Cord Trauma: An Overview Of Normal Structure And Function, Primary And Secondary Mechanisms Of Injury, And Emerging Treatment Modalities, Daniel Morin
Senior Honors Theses
The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within. While it does offer remarkable protection against most routine trauma, the spinal cord is still vulnerable to high-force etiologies of trauma and may become damaged as a result. These events are referred to as primary injury. Following the initial injury, the body’s own physiological responses cause a cascade of deleterious effects, known as secondary injury. Secondary injury is a major therapeutic target in mitigating the effects of spinal cord injury (SCI), and much research is …
Aβ Alters The Dna Methylation Status Of Cell-Fate Genes In An Alzheimer’S Disease Model, Gary D. Isaacs, Noor Taher, Courtney Mckenzie, Rebecca Garrett, Matthew Baker, Nena Fox
Aβ Alters The Dna Methylation Status Of Cell-Fate Genes In An Alzheimer’S Disease Model, Gary D. Isaacs, Noor Taher, Courtney Mckenzie, Rebecca Garrett, Matthew Baker, Nena Fox
Faculty Publications and Presentations
Alzheimer’s disease (AD) is characterized by neurofibrillary tangles and extracellular amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding the role of Aβ in the pathogenesis of this neurodegenerative disease. While several studies have focused on the mutations associated with AD, our understanding of the epigenetic contributions to the disease remains less clear. To that end, we determined the changes in DNA methylation in differentiated human neurons with and without Aβ treatment. We isolated the DNA from neurons treated with Aβ or vehicle, and digested the two samples with either a methylation-sensitive (HpaII) or a methylation-insensitive (MspI) restriction endonuclease. …
A Comparison Of Antibiotic Resistant Escherichia Coli To The Wild Type Strain, Matthew Thomas Schreiner
A Comparison Of Antibiotic Resistant Escherichia Coli To The Wild Type Strain, Matthew Thomas Schreiner
Senior Honors Theses
Antibiotic resistance is a growing problem that has rendered many antibiotics ineffective. Bacteria can gain resistance through spontaneous mutations and horizontal gene transfer. A better understanding of the overarching effects of antibiotic resistance on resistant strains is necessary when considering possible solutions to this issue. Tetracycline and doxycycline resistant strains of E. coli were compared to a wild type K-12 strain to determine if resistance engenders any fitness costs. The different strains were compared using antibiotic sensitivity tests, growth rate analysis and metabolic tests. The resistant strains actually grew at a slightly faster rate than the wild type strain. However, …
Purification Of 10-5a9 Antigen In Alzheimer's Disease, Gary Isaacs
Purification Of 10-5a9 Antigen In Alzheimer's Disease, Gary Isaacs
Senior Honors Theses
Alzheimer's Disease (AD) is a neurodegenerative disorder that results in memory loss and reduced cognitive function. Characteristic lesions include senile plaques and neurofibrillary tangles. Evidence for a previously unknown component, cockroach 10-5A9 antigen, within these lesions has recently been discovered. It is the purpose of this study to purify to 10-5A9 antigen for further analysis. Immunohistochemistry was used to determine the antigen's presence in AD lesions and the Lewy bodies of Parkinson's disease. Although SDS-PAGE/Western blotting and immunoprecipitation techniques proved ineffective, the former indicated antigen presence in the particulate matter of AD brain homogenates. Negative results from ammonium sulfate experiments …