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Full-Text Articles in Biology
Anti-C1q Autoantibodies Are Frequently Detected In Patients With Systemic Sclerosis Associated With Pulmonary Fibrosis, C. Liaskos, S. Rentouli, T. Simopoulou, A. Gkoutzourelas, G. L. Norman, A. Brotis, I. Alexiou, C. Katsiari, D. P. Bogdanos, L. I. Sakkas
Anti-C1q Autoantibodies Are Frequently Detected In Patients With Systemic Sclerosis Associated With Pulmonary Fibrosis, C. Liaskos, S. Rentouli, T. Simopoulou, A. Gkoutzourelas, G. L. Norman, A. Brotis, I. Alexiou, C. Katsiari, D. P. Bogdanos, L. I. Sakkas
Biological Sciences Faculty Publications
BACKGROUND: Anti-C1q autoantibodies (autoAbs) are associated with systemic lupus erythematosus (SLE) but their presence in other rheumatic diseases has not been adequately investigated.
OBJECTIVE: We aim to assessanti-C1q autoAbs and circulating immune complexes (CICs) in systemic sclerosis (SSc).
METHODS: One hundred twenty four patients with SSc (106 females; median age 59.4 years, range 25-81.4; 75(60.5%) with limited cutaneous SSc[lcSSc], and 49(39.5%) with diffuse cutaneous SSc[dcSSc]), were studied. Twenty-five patients with Sjögren's syndrome (SjS), 29 with rheumatoid arthritis (RA), and 38 patients with systemic lupus erythematosus (SLE) and 53 healthy controls (NC) were also included. ELISAs with high and low salt …