Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Biology
Semester-Long Course-Based Research Project In Second-Semester Organic Chemistry: Synthesizing Potential Lead Compounds For The Treatment Of A Neglected Tropical Disease, Kerry L. Barnett, Kevin M. Shea, Catherine Mcgeough, Kristine Trotta, Steven A. Williams, Minh Ly, Kathryn Aloisio
Semester-Long Course-Based Research Project In Second-Semester Organic Chemistry: Synthesizing Potential Lead Compounds For The Treatment Of A Neglected Tropical Disease, Kerry L. Barnett, Kevin M. Shea, Catherine Mcgeough, Kristine Trotta, Steven A. Williams, Minh Ly, Kathryn Aloisio
Chemistry: Faculty Publications
A semester-long research project for second-semester organic chemistry lab sections was developed. Student projects were based on preliminary data from faculty research that suggested the natural product neurolenin B to be a treatment for lymphatic filariasis. Students isolated neurolenins from the Central American plant Neurolaena lobata and proposed syntheses of previously unknown analogues using reactions learned in first- and second-semester organic chemistry. Using literature-based procedures, students ran reactions on neurolenins and analyzed their results by TLC and NMR spectroscopy. The semester culminated with a public poster session and final report using the Organic Letters template. Students in a total of …