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Elastin-Like Polypeptide As A Model To Study Intrinsically Disordered Proteins, Sadegh Majdi
Elastin-Like Polypeptide As A Model To Study Intrinsically Disordered Proteins, Sadegh Majdi
Theses and Dissertations
The elastin-like polypeptide (ELP) is a well-studied structural protein that is easily amenable to amino acid (AA) sequence modifications and has the potential to yield a wide variety of uses in bioengineering and biomedical applications. One unique property of ELP is the inclusion of intrinsically disordered domains (IDP) within the structure that allow for its diversity of physical properties. While it is generally understood that amino acid sequence dictates protein folding arrangements, the contributions of specific amino acid sequences to the intrinsic disorder of ELP has yet to be fully resolved. Therefore, identifying the contributions of specific amino acid sequences …