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Full-Text Articles in Bioinformatics
Database Methods For Copy Number Variant Analysis Of One Hundred Disease Associated Genes In Human Congenital Heart Disease, Maureen E. Tuffnell
Database Methods For Copy Number Variant Analysis Of One Hundred Disease Associated Genes In Human Congenital Heart Disease, Maureen E. Tuffnell
Master's Theses (2009 -)
Human genetic variation occurs more commonly than was recognized after the completion of the Human Genome Sequencing Project in 2003. Submicroscopic human DNA analysis has revealed copy number variation (CNV) as the deletion or duplication of a genomic region potentially affecting gene dosage. Advanced genetic research now includes the study of CNVs in diseased subject groups compared to in house controls or online published datasets of control CNV data. Research labs choose from different bioinformatic algorithms to make the copy number calls. Solutions for further processing the copy number data into quantifiable form require collaboration with data analysts and include …
Heuristics For Scaling Up Distributed Protein Docking, Prachi Pradeep
Heuristics For Scaling Up Distributed Protein Docking, Prachi Pradeep
Master's Theses (2009 -)
Docking is a computational technique which predicts the interaction between a protein and a potential drug compound. Virtual screening is a tool, which employs docking, to investigate huge libraries of compounds and predicts potential drug molecules that bind favorably to the protein of interest. The size of one such commercially available library is about 13 million compounds. It would take approximately 400 years of CPU time to examine this library! As an alternative a high performance computing application with a distributed docking strategy is needed, which can efficiently predict the favorable compounds and can eventually be scaled for huge libraries. …