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Articles 1 - 6 of 6
Full-Text Articles in Bioinformatics
Development, Design, And Utilization Of A Reflective Based Photoplethysmography Sensor, Madeline Mazjanis
Development, Design, And Utilization Of A Reflective Based Photoplethysmography Sensor, Madeline Mazjanis
Electronic Theses and Dissertations
Plethysmography refers to the dynamic measurement of biological tissue volumes that, for example, may change due to fluctuations in blood volume. Photoplethysmography (PPG) makes use of the attenuation of light penetrating into vascular tissues to determine these changes in blood volume. Modern PPG is an optical technique involving low cost photosensors and light emitting diodes (LED), and is capable of measuring multiple biological vitals simultaneously. For example, in addition to heart rate determination, PPG devices can be used as pulse oximeters, capable of calculating the blood oxygen saturation (SpO2) through a series of simple optical calculations performed on either reflectance …
Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das
Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das
Electronic Theses and Dissertations
Recently, gene set analysis has become the first choice for gaining insights into the underlying complex biology of diseases through high-throughput genomic studies, such as Microarrays, bulk RNA-Sequencing, single cell RNA-Sequencing, etc. It also reduces the complexity of statistical analysis and enhances the explanatory power of the obtained results. Further, the statistical structure and steps common to these approaches have not yet been comprehensively discussed, which limits their utility. Hence, a comprehensive overview of the available gene set analysis approaches used for different high-throughput genomic studies is provided. The analysis of gene sets is usually carried out based on …
Modified-Half-Normal Distribution And Different Methods To Estimate Average Treatment Effect., Jingchao Sun
Modified-Half-Normal Distribution And Different Methods To Estimate Average Treatment Effect., Jingchao Sun
Electronic Theses and Dissertations
This dissertation consists of three projects related to Modified-Half-Normal distribution and causal inference. In my first project, a new distribution called Modified-Half-Normal distribution was introduced. I explored a few of its distributional properties, the procedures for generating random samples based on Bayesian approaches, and the parameter estimation based on the method of moments. The second project deals with the problem of selection bias of average treatment effect (ATE) if we use the observational data. I combined the propensity score based inverse probability of treatment weighting (IPTW) method and the directed acyclic graph (DAG) to solve this problem. The third project …
A Genomic Analysis Of Bobcat Populations In North America With A Comparison To The Canada Lynx: An Assessment Of Local Adaptation To Unique Ecoregions And Phylogeography, Jennifer C. Broderick
A Genomic Analysis Of Bobcat Populations In North America With A Comparison To The Canada Lynx: An Assessment Of Local Adaptation To Unique Ecoregions And Phylogeography, Jennifer C. Broderick
Electronic Theses and Dissertations
Bobcats (Lynx rufus) are an ecologically and genetically diverse species with a large contiguous range throughout North America. The species not only has a wide array of phenotypic variation compared to other mammals, but shows marked adaptability across ecozones with differing ecological influences. It is these various selective pressures in distinctive parts of the continent that have likely led to localized adaptations within the bobcat metapopulations. The species is also marked by its ability to maintain connectivity and populations in anthropogenically developed areas, an advantage it has over other felids, including its close relative the Canada lynx ( …
Small Rnas: Big Roles In White Mold Infecting Crop Plants, Achal Neupane
Small Rnas: Big Roles In White Mold Infecting Crop Plants, Achal Neupane
Electronic Theses and Dissertations
In eukaryotes, small RNAs (sRNAs) are key regulators of RNA silencing which is also known as RNA interference (RNAi). RNAi is an essential mechanism known in plants, animals and fungi that regulates various biological activities, including defense against foreign nucleic acids and viruses. Fungal pathogens, such as Sclerotinia sclerotiorum, severely limit crop production in all parts of the world. Sclerotinia sclerotiorum cause white mold infection, affecting all dicotyledonous plants including many economically important field crops, vegetables, and floriculture. There does not exist known host resistance, and only limited chemical control can be achieved. Given the growing cost and environmental impacts …
Plasticity And The Impact Of Increasing Temperature On A Tropical Ectotherm, Adam A. Rosso
Plasticity And The Impact Of Increasing Temperature On A Tropical Ectotherm, Adam A. Rosso
Electronic Theses and Dissertations
Organisms may respond to climate change through behavior, genetic adaptation, and/or phenotypic plasticity. Tropical ectotherms are thought to be especially vulnerable to climate change because most have a narrow range of thermal tolerance while living close to their upper thermal tolerance limits. Additionally, many tropical species live in closed-canopy forests, which provide homogenous thermal landscapes that prevent behavioral compensation for stressfully warm temperatures. Finally, tropical ectotherms are thought to have decreased capacity for phenotypic plasticity because they have evolved in thermally stable environments. We tested gene expression patterns and phenotypic plasticity in the Panamanian slender anole by a) measuring changes …