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Full-Text Articles in Bioinformatics
A Pairwise Feature Selection Method For Gene Data Using Information Gain, Tian Gui
A Pairwise Feature Selection Method For Gene Data Using Information Gain, Tian Gui
Electronic Theses and Dissertations
The current technical practice for doing classification has limitations when using gene expression microarray data. For example, the robustness of top scoring pairs does not extend to some datasets involving small data size and the gene set with best discrimination power may not be involve a combination of genes. Hence, it is necessary to construct a discriminative and stable classifier that generates highly informative gene sets. As we know, not all the features will be active in a biological process. So a good feature selector should be robust with respect to noise and outliers; the challenge is to select the …
Protein Kinases: Structure Modeling, Inhibition, And Protein-Protein Interactions, Khaled M. Elokely
Protein Kinases: Structure Modeling, Inhibition, And Protein-Protein Interactions, Khaled M. Elokely
Electronic Theses and Dissertations
Human protein kinases belong to a large and diverse enzyme family that contains more than 500 members. Deregulation of protein kinases is associated with many disorders, and this is why protein kinases are attractive targets for drug discovery. Due to the high conservation of the ATP binding pocket among this family, designing specific and/or selective inhibitors against certain member(s) is challenging. Several studies have been conducted on protein kinases to validate them as suitable drug targets. Although there are numerous target-validated protein kinases, the efforts to develop small molecule inhibitors have so far led to only a limited number of …