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Articles 1 - 3 of 3
Full-Text Articles in Bioinformatics
Predicting Marine Teleost Responses To Ocean Warming And Pollution, Akila Harishchandra
Predicting Marine Teleost Responses To Ocean Warming And Pollution, Akila Harishchandra
Electronic Theses and Dissertations
Ocean warming and pollution are two detrimental anthropogenic factors causing rapid marine ecosystem degradation recorded in the past decades. These factors alter the marine environment intolerable for many marine species, forcing them to either adapt or shift their contemporary habitat ranges to reduce the extinction risk embedded with environmental degradation. Estimating marine species’ habitat range shifts, and their potential for developing adaptive mechanisms are critical for ecosystem conservation and management, human health risk assessment, and climate change vulnerability assessments. Given that, for the first chapter of this thesis, we focused on developing a species distribution model (SDM) integrating marine species …
Deciphering The Perpetual Fight Between Virus And Host: Utilizing Bioinformatics To Elucidate The Host's Genetic Mechanisms That Influence Jc Polyomavirus Infection, Michael P. Wilczek
Deciphering The Perpetual Fight Between Virus And Host: Utilizing Bioinformatics To Elucidate The Host's Genetic Mechanisms That Influence Jc Polyomavirus Infection, Michael P. Wilczek
Electronic Theses and Dissertations
JC polyomavirus (JCPyV) is a human-specific pathogen that infects 50-80% of the population, and can cause a deadly, demyelinating disease, known as progressive multifocal leukoencephalopathy (PML). In most of the population, JCPyV persistently infects the kidneys but during immunosuppression, it can reactivate and spread to the central nervous system (CNS), causing PML. In the CNS, JCPyV targets two cell types, astrocytes, and oligodendrocytes. Due to the hallmark pathology of oligodendrocyte lysis observed in disease, oligodendrocytes were thought to be the main cell type involved during JCPyV infection. However, recent evidence suggests that astrocytes are targeted by the virus and act …
Collaborative Research: North East Cyberinfrastructure Consortium, Michael Eckardt, Vicki Nemeth, Carolyn Mattingly
Collaborative Research: North East Cyberinfrastructure Consortium, Michael Eckardt, Vicki Nemeth, Carolyn Mattingly
University of Maine Office of Research Administration: Grant Reports
The North East Cyberinfrastructure Consortium has finished its third year of Track-2 funding. In this report we summarize our overall progress and progress for Year 3.
In 2006, we began to organize as the five North Eastern EPSCoR states (ME, NH, VT, Rl, DE) around cyberinfrastructure. The box below describes the state of cyberinfrastructure in 2008 by which time we had developed the North East Cyberinfrastructure Consortium to position ourselves for grant opportunities that would help us to address our cyber deficits.
The Track-2 collaborative proposal submitted in January 2009 was designed to address these barriers in order enable our …