Bioinformatics Commons^™

Identification Of Transcriptionally Quiescent Regions In The Neurospora Crassa Genome, Katie Marie Groskreutz

Theses and Dissertations

Sexual reproduction and genetic exchange via meiosis are important and highly conserved processes in many living organisms. Occasionally, complications occur during meiosis that can result in chromosome abnormalities. In humans, improper chromosome development can cause life altering disorders such as Down Syndrome, Edwards Syndrome, and Patau Syndrome. Unfortunately, despite its importance, gaps remain in our knowledge of how this process works. For instance, little is known about how homolog identification occurs and what proteins identify matching chromosomes during pairing. This fundamental process occurs early during meiosis and ensures proper development of gametes.

Understanding the proteins involved during homolog pairing may …