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Full-Text Articles in Bioinformatics
Quantifying Structure And Variation In Complex Phylogenetic Data, Genevieve Geraldine Mount
Quantifying Structure And Variation In Complex Phylogenetic Data, Genevieve Geraldine Mount
LSU Doctoral Dissertations
Identifying the source and structure of variation in nature is crucial to understanding fundamental aspects of evolution. Despite a recent plethora of genetic and morphological data, many interesting questions about the relationships between different groups remain unresolved. My dissertation evaluates three approaches for identifying and quantifying the variation within phylogenetic datasets. Characterizing variation within datasets and across analytical methods gives insight into biologically interesting characters, unusual evolutionary processes, and areas for model improvement.
Network-based community detection approaches offer a powerful tool to describe variation in phylogenetic signal across the genome (i.e., gene tree variation). In Chapter 2, I investigate the …
Metabolic Network Analysis Of Filamentous Cyanobacteria, Daniel Alexis Norena-Caro
Metabolic Network Analysis Of Filamentous Cyanobacteria, Daniel Alexis Norena-Caro
LSU Doctoral Dissertations
Cyanobacteria were the first organisms to use oxygenic photosynthesis, converting CO2 into useful organic chemicals. However, the chemical industry has historically relied on fossil raw materials to produce organic precursors, which has contributed to global warming. Thus, cyanobacteria have emerged as sustainable stakeholders for biotechnological production. The filamentous cyanobacterium Anabaena sp. UTEX 2576 can metabolize multiple sources of Nitrogen and was studied as a platform for biotechnological production of high-value chemicals (i.e., pigments, antioxidants, vitamins and secondary metabolites). From a Chemical engineering perspective, the biomass generation in this organism was thoroughly studied by interpreting the cell as a microbial …