Open Access. Powered by Scholars. Published by Universities.®
Biochemistry, Biophysics, and Structural Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biochemistry (2)
- Other Biochemistry, Biophysics, and Structural Biology (2)
- Amino Acids, Peptides, and Proteins (1)
- Analysis (1)
- Applied Mathematics (1)
-
- Chemicals and Drugs (1)
- Computational Neuroscience (1)
- Enzymes and Coenzymes (1)
- Lipids (1)
- Macromolecular Substances (1)
- Mathematics (1)
- Medicine and Health Sciences (1)
- Molecular Biology (1)
- Neuroscience and Neurobiology (1)
- Numerical Analysis and Computation (1)
- Other Applied Mathematics (1)
- Partial Differential Equations (1)
- Physical Sciences and Mathematics (1)
- Structural Biology (1)
- Institution
- Keyword
-
- ABC Transporter (1)
- Autophagy (1)
- BAG3 (1)
- COMPASS (1)
- Cable equation (1)
-
- Cancer epigenetics (1)
- Computational neuroscience (1)
- Dilated Cardiomyopathy (1)
- Drosophila (1)
- E. Coli (1)
- Epigenetics (1)
- Kss (1)
- MLR complex (1)
- Membrane Protein (1)
- Methionine Transport (1)
- Myofilament (1)
- Nanodisc (1)
- Numerical methods (1)
- Protein Quality Control (1)
- Protein Reconstitution (1)
- Second order PDE (1)
- Stress Response (1)
- Transcription (1)
Articles 1 - 4 of 4
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Nanodiscs: A Novel Approach To The Study Of The Methionine Abc Transporter System, Michael T. Winslow
Nanodiscs: A Novel Approach To The Study Of The Methionine Abc Transporter System, Michael T. Winslow
Master's Theses
Membrane transporter proteins play the vital role of moving compounds in and out of the cell and are essential for all living organisms. ATP Binding Cassette (ABC) family transporters function both as importers and exporters in prokaryotes. MetNI is an E. coli Type I ABC transporter responsible for the uptake of methionine into the cytosol from the cell periplasmic space through the cell membrane to maintain intracellular methionine pools. ABC transporters, like other membrane proteins, are most often mechanistically and structurally studied in vitro, solubilized by detergents. However, detergent micelles may affect the conformational changes of membrane proteins relative to …
Solving The Cable Equation, A Second-Order Time Dependent Pde For Non-Ideal Cables With Action Potentials In The Mammalian Brain Using Kss Methods, Nirmohi Charbe
Master's Theses
In this thesis we shall perform the comparisons of a Krylov Subspace Spectral method with Forward Euler, Backward Euler and Crank-Nicolson to solve the Cable Equation. The Cable Equation measures action potentials in axons in a mammalian brain treated as an ideal cable in the first part of the study. We shall subject this problem to the further assumption of a non-ideal cable. Assume a non-uniform cross section area along the longitudinal axis. At the present time, the effects of torsion, curvature and material capacitance are ignored. There is particular interest to generalize the application of the PDEs including and …
Characterizing The Dynamic Localization Of Cmi In Early Drosophila Development, Asra Habibullah
Characterizing The Dynamic Localization Of Cmi In Early Drosophila Development, Asra Habibullah
Master's Theses
The COMPASS-like family of lysine methyltransferases, MLR/MLX complexes, are epigenetic regulators that are essential for normal development through the methylation of the fourth lysine residue on histone 3 (H3K4), a universal epigenetic mark associated with active transcription. This family of complexes is highly conserved from yeast to mammals and the genes encoding the human MLR complexes have been associated with various developmental diseases and cancers (Dingwall and Fagan, 2019). In D. melanogaster, the enzymatic methyltransferase core of this complex is composed of two proteins: Cara Mitad (Cmi, also known as Lpt) and Trithorax-related (Trr). Although these proteins have been shown …
Characterization Of The Full-Length Bag3 Protein And Stress Induced Formation Of Bag3-Z, Ahmed Gamal Abdalla Zied
Characterization Of The Full-Length Bag3 Protein And Stress Induced Formation Of Bag3-Z, Ahmed Gamal Abdalla Zied
Master's Theses
Bcl2-associated athanogene-3 (BAG3) is a pro-autophagy co-chaperone that we havepreviously shown localizes to the cardiac sarcomere and is critical for proteostasis and maintenance of normal sarcomeric function. Indeed, BAG3 loss in heart failure (HF) results in accumulation of ubiquitinated sarcomeric proteins, and depressed maximum force generating capacity (Fmax). However, how BAG3 is regulated in the cell is not well understood, with uncertainty about its structure and proteoforms. During our analysis of human heart tissue, BAG3 appears as a “doublet”, with one band at 74 kDa (BAG3-Z) and a second at a higher 85 kDa (BAG3-FL). Previous studies hypothesized the full-length …