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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Physically And Chemically‑Crosslinked L‑Arginine‑Loaded Polyvinyl Alcohol‑ Hyaluronic Acid‑ Cellulose Nanocrystals Hydrogel Membranes For Wound Healing: Influence Of Crosslinking Methods On Biological Performance Of Membranes In‑Vitro, Elbadawy A. Kamoun, Elbadawy A. Kamoun
Physically And Chemically‑Crosslinked L‑Arginine‑Loaded Polyvinyl Alcohol‑ Hyaluronic Acid‑ Cellulose Nanocrystals Hydrogel Membranes For Wound Healing: Influence Of Crosslinking Methods On Biological Performance Of Membranes In‑Vitro, Elbadawy A. Kamoun, Elbadawy A. Kamoun
Nanotechnology Research Centre
Two types of polyvinyl alcohol-blended hyaluronic acid and cellulose nanocrystals (PVA/HA/CNCs) hydrogels membranes were developed as delivery agents for L-arginine using chemical/and/physical crosslinking methods for exploring biological performance of the obtained membranes. Chemically and physically/crosslinked membranes were fabricated by solution-casting and freeze-thawing techniques, respectively. The characterization of the crosslinked PVA/HA/CNCs/Larginine membranes were conducted by SEM, FTIR, TGA, swelling ratio, and in—vitro L-arginine release. Furthermore, applying two types of crosslinked membranes in vitro were investigated in terms of cytotoxicity, hemocompatibility, and cell adhesion affinity of HFB-4 cell line. Chemical and physical-crosslinked membranes were verified through the esterification and hydrogen bonds interactions, …
Novel Physically‑Crosslinked Caffeine And Vitamin C‑Loaded Pva/ Aloe Vera Hydrogel Membranes For Topical Wound Healing: Synthesis, Characterization And In‑Vivo Wound Healing Tests, Elbadawy Kamoun, Elbadawy A. Kamoun
Novel Physically‑Crosslinked Caffeine And Vitamin C‑Loaded Pva/ Aloe Vera Hydrogel Membranes For Topical Wound Healing: Synthesis, Characterization And In‑Vivo Wound Healing Tests, Elbadawy Kamoun, Elbadawy A. Kamoun
Nanotechnology Research Centre
Novel physically-crosslinked PVA membranes blended with Aloe vera extract were fabricated by solution-casting method. Physically-crosslinking process is depending on the rearrangement of PVA chains forming intermolecular hydrogen bonding with removal of water molecules using propanol as a stabilizing agent. The structure of crosslinked membranes was characterized by FT-IR, SEM, TGA, and XRD analyses and confirmed via gel faction and swelling ratio studies. Caffeine and vitamin C loaded-PVA/Aloe vera membranes were bio-assessed in terms of their impact on the wound healing using Wistar albino rats as an animal model. In vitro evaluation includes protein adsorption showed that the fabricated membranes improved …