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Articles 1 - 10 of 10
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
A Molecular Analysis Of Atlantic Menhaden (Brevoortia Tyrannus) Stock Structure, Abigail J. Lynch
A Molecular Analysis Of Atlantic Menhaden (Brevoortia Tyrannus) Stock Structure, Abigail J. Lynch
Dissertations, Theses, and Masters Projects
Atlantic menhaden is an ecologically and economically important species along the U.S. east coast. As a filter-feeder and key prey fish, it provides a critical link between primary production, phytoplankton, and larger piscivorous predators, such as striped bass, bluefish, and weakfish. The species is also the target of one of the largest commercial fisheries in the country. Menhaden are assessed as a single, coastwide stock, and recent assessments indicate that it is not overfished. However, there is very limited population genetics data to support the assumption of a single stock. Additionally, the recent consolidation of the fishery and localization of …
A Versatile Imaging System For In Vivo Small Animal Research, Jianguo Qian
A Versatile Imaging System For In Vivo Small Animal Research, Jianguo Qian
Dissertations, Theses, and Masters Projects
In vivo small animal imaging has become an essential technique for molecular biology studies. However, requirements of spatial resolution, sensitivity and image quality are quite challenging for the development of small-animal imaging systems. The capabilities of the system are also significant for carrying out small animal imaging in a wide range of biological studies. The goal of this dissertation is to develop a high-performance imaging system that can readily meet a wide range of requirements for a variety of small animal imaging applications. Several achievements have been made in order to fulfill this goal.;To supplement our system for parallel-hole single …
Novel Use Of A Natural Isotope Signature To Track Recruitment And Evaluate Age Determination Methods For The 2002 Year Class Of American Shad In The York River, Sally A. Upton
Dissertations, Theses, and Masters Projects
No abstract provided.
Probability Density Methods For Modeling Local And Global Aspects Of Intracellular Calcium Signaling, G. S. Blair Williams
Probability Density Methods For Modeling Local And Global Aspects Of Intracellular Calcium Signaling, G. S. Blair Williams
Dissertations, Theses, and Masters Projects
Considerable insight into intracellular calcium (Ca) responses has been obtained through the development of whole cell models that are based on molecular mechanisms, e.g., the kinetics of intracellular Ca channels and the feedback of Ca upon these channels. However, a limitation of most deterministic whole cell models to date is the assumption that channels are globally coupled by a single [Ca], when in fact channels experience localized "domain" Ca concentrations. More realistic stochastic Monte Carlo simulations are capable of representing individual domain Ca concentrations but suffer from increased computational demand. This dissertation introduces a novel probability approach which captures important …
The Relationship Between Antibody Redox Structure And Affinity In Rainbow Trout, Jianmin Ye
The Relationship Between Antibody Redox Structure And Affinity In Rainbow Trout, Jianmin Ye
Dissertations, Theses, and Masters Projects
Teleost immunoglobulin M (IgM), an 800 kDa tetramer, possesses considerable structural diversity due to the non-uniform disulfide polymerization of its halfmeric or monomeric subunits. However, to date, no plausible functional role for this diversity has been demonstrated or proposed. This research was, therefore, designed to investigate the possible functional role(s) for this diversity using the trout model. The possible relationship between this structural diversity and affinity was specifically addressed. The relationship between high levels of disulfide polymerization and high affinity was demonstrated by selective immunoadsorption and analysis of antibodies isolated during the process of affinity maturation. A pivotal determinative role …
Analysis Of Sequence Variation At Two Helicobacter Pylori Genetic Loci Potentially Involved In Virulence, George Warren Liechti
Analysis Of Sequence Variation At Two Helicobacter Pylori Genetic Loci Potentially Involved In Virulence, George Warren Liechti
Dissertations, Theses, and Masters Projects
No abstract provided.
Markov Chain Models Of Calcium Puffs And Sparks, Jeffrey R. Groff
Markov Chain Models Of Calcium Puffs And Sparks, Jeffrey R. Groff
Dissertations, Theses, and Masters Projects
Localized cytosolic Ca2+ elevations known as puffs and sparks are important regulators of cellular function that arise due to the cooperative activity of Ca2+-regulated inositol 1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RyRs) co-localized at Ca2+ release sites on the surface of the endoplasmic reticulum or sarcoplasmic reticulum. Theoretical studies have demonstrated that the cooperative gating of a cluster of Ca2+-regulated Ca 2+ channels modeled as a continuous-time discrete-state Markov chain may result in dynamics reminiscent of Ca2+ puffs and sparks. In such simulations, individual Ca2+-release channels are coupled via a mathematical representation of the local [Ca2+] and exhibit "stochastic Ca2+ …
Stable Isotope Dynamics In Summer Flounder Tissues, With Application To Dietary Assessments In Chesapeake Bay, Andre Buchheister
Stable Isotope Dynamics In Summer Flounder Tissues, With Application To Dietary Assessments In Chesapeake Bay, Andre Buchheister
Dissertations, Theses, and Masters Projects
Stable isotope techniques were applied to summer flounder, Paralichthys dentatus, in Chesapeake Bay to elucidate the relative importance of different prey groups on the growth and productivity of this species. Prior to field application, a laboratory diet-shift study was conducted to evaluate methodological assumptions and obtain necessary isotopic parameters. Specifically, the goals of the laboratory study were to 1) determine isotopic turnover rates and fractionations of δ13C and δ15N in liver, whole blood, and white muscle and 2) estimate the relative importance of growth and metabolic processes on isotopic turnover. Groups of captive juvenile summer flounder (130-255mm total length) were …
A Molecular Phylogeny Of The Genus Bonamia Based On Sequence Data Of The Ribosomal Rna (Rrna) Gene Complex, Delonna M. White
A Molecular Phylogeny Of The Genus Bonamia Based On Sequence Data Of The Ribosomal Rna (Rrna) Gene Complex, Delonna M. White
Dissertations, Theses, and Masters Projects
No abstract provided.
Markov Chain Models Of Instantaneously Coupled Intracellular Calcium Channels, Hilary Deremigio
Markov Chain Models Of Instantaneously Coupled Intracellular Calcium Channels, Hilary Deremigio
Dissertations, Theses, and Masters Projects
Localized calcium elevations known as calcium puffs or sparks are cellular signals arising from cooperative activity of clusters of inositol 1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RyRs) located at calcium release sites on the endoplasmic or sarcoplasmic reticulum membrane. When Markov chain models of these intracellular calcium-regulated calcium channels are coupled via a mathematical representation of the calcium microdomain, simulated calcium release sites may exhibit the phenomenon of "stochastic calcium excitability" where the IP3Rs or RyRs open and close in a concerted fashion. Although the biophysical theory relating the kinetics of single channels to the collective phenomena of puffs and …