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Biochemistry, Biophysics, and Structural Biology Commons™

Open Access. Powered by Scholars. Published by Universities.®

Department of Biological & Biomedical Sciences

2004

Articles 1 - 8 of 8

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Gene Markers And Complex Disorders: A Review, M S. Mahmood, N Kureshi, P M. Frossard Nov 2004

Gene Markers And Complex Disorders: A Review, M S. Mahmood, N Kureshi, P M. Frossard

Department of Biological & Biomedical Sciences

No abstract provided.

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Variability In Lipid Profile In Patients With Acute Myocardial Infarction From Two Tertiary Care Hospitals In Pakistan, M P. Iqbal, M Shafiq, N Mehboobali, S P. Iqbal, K Abbasi Nov 2004

Variability In Lipid Profile In Patients With Acute Myocardial Infarction From Two Tertiary Care Hospitals In Pakistan, M P. Iqbal, M Shafiq, N Mehboobali, S P. Iqbal, K Abbasi

Department of Biological & Biomedical Sciences

Objective: To investigate changes in total cholesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol and triglycerides in serum of Pakistani patients with AMI due to age, gender, body mass index (BMI), diabetes, hypertension, and smoking, and also find out the prevalence of hypercholesterolemia, hypertriglyceridemia, "low HDL-cholesterol" and "isolated low-HDL cholesterol" in them.
Patients and Methods: Serum samples from 451 consecutive AMI patients (250 from National Institute of Cardiovascular Diseases, Karachi and 201 from Armed Forces Institute of Cardiology, Rawalpindi) were analyzed for total cholesterol, HDL-cholesterol and triglycerides using kit methods. LDL-cholesterol was determined using the Friedewald formula.
Results: Mean …

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Cystic Breast Lymphangioma, S N. Waqar, H Khan, S F. Mekan, N Kayani, A J. Raja Oct 2004

Cystic Breast Lymphangioma, S N. Waqar, H Khan, S F. Mekan, N Kayani, A J. Raja

Department of Biological & Biomedical Sciences

No abstract provided.

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Immunity In Medicine, M Saeed Sep 2004

Immunity In Medicine, M Saeed

Department of Biological & Biomedical Sciences

No abstract provided.

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Involvement Of Thromboxane A2 And Tyrosine Kinase In The Synergistic Interaction Of Platelet Activating Factor And Calcium Ionophore A23187 In Human Platelet Aggregation, Huma Rasheed, Sheikh Arshad Saeed Jun 2004

Involvement Of Thromboxane A2 And Tyrosine Kinase In The Synergistic Interaction Of Platelet Activating Factor And Calcium Ionophore A23187 In Human Platelet Aggregation, Huma Rasheed, Sheikh Arshad Saeed

Department of Biological & Biomedical Sciences

The present study was carried out to examine the mechanisms of the synergistic interaction of PAF and A23187 mediated platelet aggregation. We found that platelet aggregation mediated by subthreshold concentrations of PAF (5 nM) and A23187 (1 mM) was inhibited by PAF receptor blocker (WEB 2086, IC50 = 0.65 mM) and calcium channel blockers, diltiazem (IC50 = 13 mM) and verapamil (IC50 = 18 mM). Pretreatment of platelets with PAF and A23187 induced rise in intracellular calcium and this effect was also blocked by verapamil. While examining the role of the down stream signaling pathways, we found that platelet aggregation …

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Increased Levels Of Erythrocyte Glutathione In Acute Myocardial Infarction: An Antioxidant Defence, M P. Iqbal, M Ishaq, N Mehboobali May 2004

Increased Levels Of Erythrocyte Glutathione In Acute Myocardial Infarction: An Antioxidant Defence, M P. Iqbal, M Ishaq, N Mehboobali

Department of Biological & Biomedical Sciences

Objective: Glutathione (GSH) has a central role in the defence against oxidative damage. This study was carried out to investigate any change in erythrocyte GSH levels in a population of patients with acute myocardial infarction (AMI) and compare them with levels in normal healthy subjects.
Method: GSH levels were determined in erythrocytes of one hundred and seventy six patients with AMI (age: 30-70 years; 131 males and 45 females) admitted to the National Institute of Cardiovascular Diseases, Karachi. These levels were compared with eryrocyte GSH levels obtained from 95 normal healthy subjects (controls).
Results: Mean +/- SD erythrocyte GSH levels …

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Association Study Of The Angiotensin-Converting Enzyme (Ace) Gene G2350a Dimorphism With Myocardial Infarction, M Perwaiz Iqbal, Saeed Mahmood, Naseema Mehboobali, Mohammad Ishaq, Tasnim Fatima, Saddiqa Parveen, Philippe Frossard Apr 2004

Association Study Of The Angiotensin-Converting Enzyme (Ace) Gene G2350a Dimorphism With Myocardial Infarction, M Perwaiz Iqbal, Saeed Mahmood, Naseema Mehboobali, Mohammad Ishaq, Tasnim Fatima, Saddiqa Parveen, Philippe Frossard

Department of Biological & Biomedical Sciences

The angiotensin converting enzyme (ACE) is a strong candidate gene for myocardial infarction (MI). Insertion-deletion dimorphism in intron 16 of this gene has been inconclusively found to be associated with it. Several new polymorphisms in the ACE gene have been identified and among these, a dimorphism in exon 17, ACE G2350A, has a significant effect on plasma ACE concentrations. To assess the value of genotyping the ACE G2350A dimorphism in a genetically homogeneous population, we carried out a case-control study of dimorphism G2350A for a putative association with MI among Pakistani nationals. We investigated a sample population of 370 Pakistanis, …

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Core Concepts In Biochemistry And Molecular Biology In An Integrated Mbbs Curriculum, M P. Iqbal Apr 2004

Core Concepts In Biochemistry And Molecular Biology In An Integrated Mbbs Curriculum, M P. Iqbal

Department of Biological & Biomedical Sciences

No abstract provided.

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