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Determination Of Total And Unfilterable Plasma Aluminum In Uremic Patients, Theodore R. Delbridge

Chemistry & Biochemistry Theses & Dissertations

Aluminum accumulation in the soft tissues and bone of end stage renal failure patients has been described in the literature. In addition to aluminum normally encountered through ubiquitous sources, these patients are subject to exposures through the dialysate used for hemodialysis and through aluminum-containing phosphate binders. These increased exposures, associated with a decreased ability to excrete aluminum through the kidneys, lead to aluminum accumulation which may result in the onset of an encephalopathy syndrome and/or osteomalacic osteodystrophy. These complications may be very devastating.

Blood serum or plasma aluminum levels do not reflect the total body burden of aluminum. However, they …