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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Role Of Hepatitis C Virus Inducted Osteopontin In Epithelial To Mesenchymal Transition, Migration, And Invasion Of Hepatocytes, Jawed Iqbal, Steven Mcrae, Thi Mai, Krishna Banaudha, Mehuli Sarkar-Dutta, Gulam Waris
Role Of Hepatitis C Virus Inducted Osteopontin In Epithelial To Mesenchymal Transition, Migration, And Invasion Of Hepatocytes, Jawed Iqbal, Steven Mcrae, Thi Mai, Krishna Banaudha, Mehuli Sarkar-Dutta, Gulam Waris
Biochemistry and Molecular Medicine Faculty Publications
Osteopontin (OPN) is a secreted phosphoprotein which has been linked to tumor progression and metastasis in a variety of cancers including hepatocellular carcinoma (HCC). Previous studies have shown that OPN is upregulated during liver injury and inflammation. However, the role of OPN in hepatitis C virus (HCV)-induced liver disease pathogenesis is not known. In this study, we determined the induction of OPN, and then investigated the effect of secreted forms of OPN in epithelial to mesenchymal transition (EMT), migration and invasion of hepatocytes. We show the induction of OPN mRNA and protein expression by HCV-infection. Our results also demonstrate the …