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University of Nebraska - Lincoln
Department of Biochemistry: Dissertations, Theses, and Student Research
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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Consequences Of Hyaluronan Metabolism On Cell Cycle Progression In Prostate Tumor Growth And Metastasis, Alamelu G. Bharadwaj
Consequences Of Hyaluronan Metabolism On Cell Cycle Progression In Prostate Tumor Growth And Metastasis, Alamelu G. Bharadwaj
Department of Biochemistry: Dissertations, Theses, and Student Research
Progression of Prostate cancer (CaP), depends on a complex series of interactions between the tumor and extracellular matrix (ECM) leading to tumor growth and metastasis. Hyaluronan (HA), an ECM component, is elevated in CaP and its accumulation in the tumor microenvironment is dependent on its synthetic enzyme, hyaluronan synthase (HAS), and turnover enzyme, hyaluronidase (Hyal). Although Hyal1 expression can independently prognosticate CaP, and HAS expression shows increase in aggressive prostate cancer cells, the functional relevance of this correlation is unexplored. In these studies we aim to dissect the roles of HAS and Hyal1 in prostate cancer.
Stably overexpressed hyaluronan synthases …