Open Access. Powered by Scholars. Published by Universities.®
Biochemistry, Biophysics, and Structural Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Alzheimer's (1)
- Amyloid-beta (1)
- Antibody (1)
- Covid-19 (1)
- DNA (1)
-
- Drug molecules (1)
- Electrochemical impedance spectroscopy (1)
- Electrochemistry. (1)
- Expression (1)
- Fluorescence (1)
- Glycocurcuminoids (1)
- Hierarchical bimodal nanoporous gold (1)
- Kinetic assay (1)
- MAbSL (1)
- Mass spectrometry (1)
- Membrane proteins (1)
- Monolith (1)
- Neurodegeneration (1)
- Plasmid (1)
- Protofibrils (1)
- Purification (1)
- Quartz crystal microbalance (1)
- Sepsis (1)
Articles 1 - 2 of 2
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Binding Interactions Of Biologically Relevant Molecules Studied Using Surface-Modified And Nanostructured Surfaces, Palak Sondhi
Binding Interactions Of Biologically Relevant Molecules Studied Using Surface-Modified And Nanostructured Surfaces, Palak Sondhi
Dissertations
This research focuses on the field of surface nanobioscience, wherein different nanosurfaces that will be used as working electrodes in the electrochemical cell are manufactured and surface modified to understand the critical binding interactions between biologically significant molecules like proteins, carbohydrates, small drug molecules, and glycoproteins. This research is essential if we are to determine whether a synthetic molecule can serve as a therapeutic candidate or diagnose a disease in its early stages. In order to fully understand the binding interactions, the study begins with defining some of the fundamental concepts, principles, and analytical tools for biosensing.
Afterwards, we addressed …
Probing Amyloid-Beta Protein Structure And Dynamics With A Selective Antibody, Shikha Grover
Probing Amyloid-Beta Protein Structure And Dynamics With A Selective Antibody, Shikha Grover
Dissertations
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. The AD brain is characterized by significant neuronal loss and accumulation of insoluble fibrillar amyloid-β protein (Aβ) plaques and tau protein neurofibrillary tangles in the brain. However, over the last decade, many studies have shown that the neurodegenerative effect of Aβ may in fact be caused by various soluble oligomeric forms as opposed to the insoluble fibrils. Furthermore, the data suggest that a pre-fibrillar aggregated form, termed protofibrils, mediates direct neurotoxicity, and triggers a robust neuroinflammatory response.
Antibodies targeting the various conformation of Aβ are important therapeutic agents to prevent the progression …