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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Effect Of Tamoxifen On Proteome Expression During In Vitro Myogenesis In Murine Skeletal Muscle C2C12 Cells, Emily A. Morris, Ahlenne Abreu, S. P. Scordilis
Effect Of Tamoxifen On Proteome Expression During In Vitro Myogenesis In Murine Skeletal Muscle C2C12 Cells, Emily A. Morris, Ahlenne Abreu, S. P. Scordilis
Biological Sciences: Faculty Publications
Tamoxifen (TMX), a selective estrogen receptor modulator, is commonly used in the treatment of hormone-responsive cancers. However, the effects of TMX in anabolic tissues harboring estrogen receptors, such as skeletal muscle, are poorly understood. We report a tandem mass-tag approach to TMX-treated myogenesis in C2C12 cells, a well-characterized model of in vitro murine skeletal muscle differentiation. A longitudinal analysis of >10,000 proteins identified in untreated C2C12 myogenesis revealed a novel subset of 1,062 myogenically regulated proteins. These proteins clustered into five distinct longitudinal expression trends which significantly overlap those obtained in similar analyses performed …
Will Populations Of Macroinvertebrate Functional Feeding Groups Survive Precipitation Changes?, Malika Gottfried, Laura Kim, Sophia Zuccala
Will Populations Of Macroinvertebrate Functional Feeding Groups Survive Precipitation Changes?, Malika Gottfried, Laura Kim, Sophia Zuccala
Other Student Projects
Climate change is a pervasive issue that has the potential to have detrimental effects on many freshwater organisms and their habitats. Fluctuations in precipitation, changes in temperature, and other long-term shifts in weather patterns are just a few examples of the ways in which climate change is impacting the world around us (“What is Climate Change?” n.d.). The Mill River in Northampton, Massachusetts is an ideal location to measure some of these impacts on macroinvertebrates in various functional feeding groups. Macroinvertebrates are small organisms that lack an internal skeletal system, and their functional feeding groups refer to “the type of …