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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Synthesis Of Resveratrol Esters And Aliphatic Acids., Stanley Mofor Jing
Synthesis Of Resveratrol Esters And Aliphatic Acids., Stanley Mofor Jing
Electronic Theses and Dissertations
Resveratrol (RV) is a naturally occurring phytoalexin of the stilbenoid family produced by some plant species, and present in grape skin, peanuts, and red wine. It has been found to exhibit anti-cancer, anti-inflammatory, anti-viral, anti-aging, cardio protective, and anti-oxidant properties. Bioavailability is a huge setback that limits the potentials of RV. As a result, efforts have been made to design and synthesize RV esters and aliphatic acids in an attempt to increase its bioavailability, solubility in water, and possibly improving its biological activities. Resveratrol esters, 3,5,4'-triacetyloxystilbene (2) and Methyl 1,1',1''- (3,4',5-stilbenyl)-1,6-hexanedioate (3) have been synthesized. Compound 3 is a new …
A Predictive Model Which Uses Descriptors Of Rna Secondary Structures Derived From Graph Theory., Alissa Ann Rockney
A Predictive Model Which Uses Descriptors Of Rna Secondary Structures Derived From Graph Theory., Alissa Ann Rockney
Electronic Theses and Dissertations
The secondary structures of ribonucleic acid (RNA) have been successfully modeled with graph-theoretic structures. Often, simple graphs are used to represent secondary RNA structures; however, in this research, a multigraph representation of RNA is used, in which vertices represent stems and edges represent the internal motifs. Any type of RNA secondary structure may be represented by a graph in this manner. We define novel graphical invariants to quantify the multigraphs and obtain characteristic descriptors of the secondary structures. These descriptors are used to train an artificial neural network (ANN) to recognize the characteristics of secondary RNA structure. Using the ANN, …
Molecular Modulation Of A-Subunit Visit-Dg Sequence Residue Asp-350 In The Catalytic Sites Of Escherichia Coli Atp Synthase., Sneha R. Jonnalagadda
Molecular Modulation Of A-Subunit Visit-Dg Sequence Residue Asp-350 In The Catalytic Sites Of Escherichia Coli Atp Synthase., Sneha R. Jonnalagadda
Electronic Theses and Dissertations
ATP Synthase is the fundamental means of cellular energy production in animals, plants, and almost all microorganisms. In order to understand the mechanism of ATP catalysis, critical amino acid residues involved in Pi binding have to be identified. The αVISIT-DG sequence at the interface of α/β subunits that contains residues from 345-351 is highly conserved and αAsp-350 has been chosen because of its negative charge side chain and its close proximity (~2.8 Å) to the known phosphate binding residue αArg-376. The mutant's αD350R, αD350Q, αD350A, αR376A/D, and αG351R/A/D were generated by site directed mutagenesis and several biochemical assays were performed …