Biochemistry, Biophysics, and Structural Biology Commons^™

Analyzing Conformational Changes In The Binding Of Hiv-1 Matrix Protein, N And C Terminals, To Calmodulin, Nousha Karimi, Fabian Valdez, Davis Mau, K. Sakamaki

Student Scholar Symposium Abstracts and Posters

Worldwide, more than 38 million people are living with human immunodeficiency virus (HIV), about 84 million people have become infected with HIV since the start of the epidemic, and 40.1 million of those diagnoses led to death. HIV Type-1 is the most common type of HIV, attacking the body’s immune system by destroying CD4 cells. The virus attaches itself to the CD4 cell, taking control of its DNA and replicating itself to release more HIV into the bloodstream. The Gag proteins of HIV-1 are crucial players in the virus’ assembly, release, and maturation; it utilizes its essential matrix protein (MA) …