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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Identifying A Target Protein And Ligands For Autoimmune Disorders, Sarah Caruthers
Identifying A Target Protein And Ligands For Autoimmune Disorders, Sarah Caruthers
Computational and Data Sciences (MS) Theses
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by unprovoked inflammatory responses that lead to tissue degradation. Patients suffering from SLE display an overexpression of master regulatory protein HIF-1 HIF-1is a transcription factor for pro-inflammatory cytokine interleukin-17A (IL-17A), which is highly involved in inflammatory reactions within the body. To search for a treatment for SLE, computer aided drug discovery techniques were utilized. The transcription factor complex for IL-17A was reconstructed through multiple protein docking techniques. The heteroprotein complex was profiled using 3D macromolecular visualization software and binding cavities within HIF-1 were calculated. Molecular docking simulations were run on the …